APBB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APBB2_MOUSE
• UniProt AC: Q9DBR4
• Protein Name: Amyloid-beta A4 precursor protein-binding family B member 2
• Gene Name: Apbb2
• Organism: Mus musculus (Mouse).
• Sequence Length: 760
• Protein Description: May modulate the internalization of amyloid-beta precursor protein..
• Protein Sequence: MSEVLPADSGVGTLAVFMASSGSTDIANRNSPATPPNTLNLRSSHNELLNAEIKHSDAKNSTPPKCRKKYALTNIQAAMGLSDPAVQPLLGNGSANIKLVKNGENQLRKAAEQGQQDPNKNLSPAAVINLTSEKLEVKDPHPQESSGCEILPSQPRRTKSFLNYYADLETSARELGQNLGPCQGVGEEKAQPGPGQAPVVIGNGDLLPQKPNKPQSSPEDGQVATVSSSPETKKDHPKTGAKTDCALHRIQNLAPSDEESSWTTLSQDSASPSSPDETDIWSDHSFQTDPDLPPGWKRVNDIAGTYYWHIPTGTTQWERPVSIPADLHGSRKGSLSSVTPSPTPENEKQPWSDFAVLNGGKINSDIWKDLHAATVNPDPSLKEFEGATLRYASLKLRNAPHGDDDDSCSINSDPEAKCFAVRSLGWVEMAEEDLAPGKSSVAVNNCIRQLSYCKNDIRDTVGIWGEGKDMYLSLENDMLSLVDPMDRSVLHSQPIVNIRVWGVGRDNGRERDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERKNAKALACSSLQERTNMSLDVPLQVDFPTPKTELVQKFRVQYLGMLPVDRPVGMDTLNSAIENLMTSSSKEDWPSVNMNVADATVTVISEKNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRFECHVFWCEPNAANVSEAVQAACMLRYQKCLVARPPSQKVRPPPPPADSVTRRVTTNVKRGVLSLIDTLKQKRPVTETP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	TDIANRNSPATPPNT CCCCCCCCCCCCCCC	16.81	25777480
34	Phosphorylation	ANRNSPATPPNTLNL CCCCCCCCCCCCCCC	42.54	25521595
38	Phosphorylation	SPATPPNTLNLRSSH CCCCCCCCCCCCCHH	23.85	24759943
43	Phosphorylation	PNTLNLRSSHNELLN CCCCCCCCHHHHHHH	38.83	27681418
44	Phosphorylation	NTLNLRSSHNELLNA CCCCCCCHHHHHHHH	24.73	27681418
61	Phosphorylation	KHSDAKNSTPPKCRK CCHHCCCCCCCCHHH	41.40	24719451
62	Phosphorylation	HSDAKNSTPPKCRKK CHHCCCCCCCCHHHH	53.67	27681418
123	Phosphorylation	QDPNKNLSPAAVINL CCCCCCCCHHHHEEC	23.14	26824392
131	Phosphorylation	PAAVINLTSEKLEVK HHHHEECCCCCCCCC	30.28	25777480
132	Phosphorylation	AAVINLTSEKLEVKD HHHEECCCCCCCCCC	35.58	25777480
158	Phosphorylation	LPSQPRRTKSFLNYY CCCCCCCCHHHHHHH	32.11	21082442
160	Phosphorylation	SQPRRTKSFLNYYAD CCCCCCHHHHHHHHH	34.06	26824392
164	Phosphorylation	RTKSFLNYYADLETS CCHHHHHHHHHHHHH	11.37	21082442
165	Phosphorylation	TKSFLNYYADLETSA CHHHHHHHHHHHHHH	7.80	27717184
216	Phosphorylation	QKPNKPQSSPEDGQV CCCCCCCCCCCCCCE	57.28	29550500
217	Phosphorylation	KPNKPQSSPEDGQVA CCCCCCCCCCCCCEE	27.36	29550500
225	Phosphorylation	PEDGQVATVSSSPET CCCCCEEEECCCCCC	23.28	29472430
227	Phosphorylation	DGQVATVSSSPETKK CCCEEEECCCCCCCC	22.27	29472430
228	Phosphorylation	GQVATVSSSPETKKD CCEEEECCCCCCCCC	45.64	29472430
229	Phosphorylation	QVATVSSSPETKKDH CEEEECCCCCCCCCC	21.17	29472430
232	Phosphorylation	TVSSSPETKKDHPKT EECCCCCCCCCCCCC	46.94	29472430
315	Phosphorylation	WHIPTGTTQWERPVS EECCCCCCCCCCCEE	32.79	21183079
330	Phosphorylation	IPADLHGSRKGSLSS CCCCCCCCCCCCCCC	21.77	26824392
334 (in isoform 3)	Phosphorylation	-	28.28	27180971
334 (in isoform 2)	Phosphorylation	-	28.28	27180971
334	Phosphorylation	LHGSRKGSLSSVTPS CCCCCCCCCCCCCCC	28.28	25521595
336	Phosphorylation	GSRKGSLSSVTPSPT CCCCCCCCCCCCCCC	25.18	25619855
336 (in isoform 3)	Phosphorylation	-	25.18	20531401
336 (in isoform 2)	Phosphorylation	-	25.18	20531401
337 (in isoform 2)	Phosphorylation	-	34.99	22942356
337 (in isoform 3)	Phosphorylation	-	34.99	22942356
337	Phosphorylation	SRKGSLSSVTPSPTP CCCCCCCCCCCCCCC	34.99	27742792
339	Phosphorylation	KGSLSSVTPSPTPEN CCCCCCCCCCCCCCC	21.72	27087446
339 (in isoform 2)	Phosphorylation	-	21.72	20531401
339 (in isoform 3)	Phosphorylation	-	21.72	20531401
341	Phosphorylation	SLSSVTPSPTPENEK CCCCCCCCCCCCCCC	31.85	26824392
341 (in isoform 2)	Phosphorylation	-	31.85	20531401
341 (in isoform 3)	Phosphorylation	-	31.85	20531401
343	Phosphorylation	SSVTPSPTPENEKQP CCCCCCCCCCCCCCC	47.80	25619855
343 (in isoform 2)	Phosphorylation	-	47.80	20531401
343 (in isoform 3)	Phosphorylation	-	47.80	20531401
352	Phosphorylation	ENEKQPWSDFAVLNG CCCCCCCCCEEEECC	29.54	25168779
353 (in isoform 3)	Phosphorylation	-	31.49	20531401
353 (in isoform 2)	Phosphorylation	-	31.49	20531401
359 (in isoform 2)	Phosphorylation	-	34.31	20531401
359 (in isoform 3)	Phosphorylation	-	34.31	20531401
364	Phosphorylation	LNGGKINSDIWKDLH ECCCCCCHHHHHHHH	33.67	19060867
380	Phosphorylation	ATVNPDPSLKEFEGA CCCCCCCCHHHCCCC	60.50	26824392
393	Phosphorylation	GATLRYASLKLRNAP CCCEEEEEEEECCCC	19.66	-
407	Phosphorylation	PHGDDDDSCSINSDP CCCCCCCCCCCCCCH	19.43	27087446
409	Phosphorylation	GDDDDSCSINSDPEA CCCCCCCCCCCCHHH	28.85	27087446
412	Phosphorylation	DDSCSINSDPEAKCF CCCCCCCCCHHHCEE	53.52	27087446
460	Phosphorylation	CKNDIRDTVGIWGEG CCCCHHHCCEECCCC	15.70	27180971
718	Phosphorylation	CLVARPPSQKVRPPP HEEECCCCCCCCCCC	45.37	29472430
749	Phosphorylation	GVLSLIDTLKQKRPV HHHHHHHHHHHHCCC	28.94	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APBB2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APBB2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APBB2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APBB2_MOUSE	Apbb2	physical	15629131
MK08_MOUSE	Mapk8	physical	15629131

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.