| UniProt ID | IRAK2_MOUSE | |
|---|---|---|
| UniProt AC | Q8CFA1 | |
| Protein Name | Interleukin-1 receptor-associated kinase-like 2 | |
| Gene Name | Irak2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 622 | |
| Subcellular Localization | ||
| Protein Description | Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.. | |
| Protein Sequence | MACYIYQLPSWVLDDLCRNIDTLSEWDWMQFASYVITDLTQLRKIKSMERVQGVSITRELLWWWSMRQATVQQLVDLLCHLELYRAAQIVLSWKPVPESTSPLPAFPEAVKPGAVATSRRNLKDEQEKVRPVKPRSLLDTGPIMAGAQRQRPCEMDAPCSLKTDAPDSPQSKYCSTSTSAPKQERLLGLPGDRLFWSEADVVQATEDFDQSHRISEGTFADIYQGQRNGVAFAFKKLREVAGSSPGSMDRFLQAEMQLCLRCCHANVLPLLGFCTGRQFHSLIYPYMANGSLHDRLWAQGNSDMLPWPQRASICSGLLLAVEHLHSLDIIHSNVKSANVLLDQHLNPKLAHPVAHPHPDNKKTKYTVMRTHLFQASAAYLPEHFIRVGQLTKQVDIFSCGIVLAEVLTGIPAMDKDRSPVYLKDLLLSEIPNSTSSVCSRKTSMGKAVVKEICQRHVEKRAGLLPEACEEAWATAVSVCLRRRNASVEEARVSLAGVEEQLRGQLSLPWSRVSEATGSSSNTPEETDDVDNSSLSVPSLVMMASCPGAASSPLFTGHGAAQPSTSGRQEADSSSEACTGPQTPQNATETSWKIEINEAKRRLMENIVLYKEERLDSSELFGP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 50 | Methylation | RKIKSMERVQGVSIT HHHCCCCCCCCCCHH | 19.88 | 16188333 | |
| 136 | Phosphorylation | VRPVKPRSLLDTGPI CCCCCCHHHHCCCCC | 41.64 | 25159016 | |
| 140 | Phosphorylation | KPRSLLDTGPIMAGA CCHHHHCCCCCCCCC | 44.84 | 25159016 | |
| 163 | Phosphorylation | DAPCSLKTDAPDSPQ CCCCCCCCCCCCCCC | 42.56 | 20531401 | |
| 168 | Phosphorylation | LKTDAPDSPQSKYCS CCCCCCCCCCCCCCC | 24.63 | 23684622 | |
| 171 | Phosphorylation | DAPDSPQSKYCSTST CCCCCCCCCCCCCCC | 29.04 | 30635358 | |
| 173 | Phosphorylation | PDSPQSKYCSTSTSA CCCCCCCCCCCCCCC | 9.25 | 20531401 | |
| 175 | Phosphorylation | SPQSKYCSTSTSAPK CCCCCCCCCCCCCCH | 23.46 | 20531401 | |
| 176 | Phosphorylation | PQSKYCSTSTSAPKQ CCCCCCCCCCCCCHH | 32.25 | 20531401 | |
| 177 | Phosphorylation | QSKYCSTSTSAPKQE CCCCCCCCCCCCHHH | 12.22 | 20531401 | |
| 178 | Phosphorylation | SKYCSTSTSAPKQER CCCCCCCCCCCHHHH | 29.06 | 20531401 | |
| 179 | Phosphorylation | KYCSTSTSAPKQERL CCCCCCCCCCHHHHH | 42.20 | 20531401 | |
| 506 | Phosphorylation | EQLRGQLSLPWSRVS HHHCCCCCCCHHHHH | 25.21 | 28725479 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IRAK2_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IRAK2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IRAK2_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of IRAK2_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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