CXXC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CXXC1_MOUSE
• UniProt AC: Q9CWW7
• Protein Name: CXXC-type zinc finger protein 1
• Gene Name: Cxxc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 660
• Subcellular Localization: Nucleus.
• Protein Description: Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG..
• Protein Sequence: MEGDGSDLEPPDAGDDSKSENGENAPIYCICRKPDINCFMIGCDNCNEWFHGDCIRITEKMAKAIREWYCRECREKDPKLEIRYRHKKCRERDGSERAGSEPRDEGGGRKRPASDPELQRRAGSGTGVGAMLARGSASPHKSSPQPLVATPSQHHHQQQQQQQQQIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIRQKCRLRQCQLRARESYKYFPSSLSPVTPSEALPRPRRPPPTQQQPQQSQKLGRIREDEGTVLSSVVKEPPEATATPEPLSDEDLALDPDLYQDFCAGAFDDHGLPWMSDAEESPFLDPALRKRAVKVKHVKRREKKSEKKKEERYKRHRQKQKHKDKWKHPERADAKDPASLPQCLGPGCVRAAQPGSKYCSDDCGMKLAANRIYEILPQRIQQWQQSPCIAEEHGKKLLERIRREQQSARTRLQEMERRFHELEAIILRAKQQAVREDEENNENDSDDTDLQIFCVSCGHPINPRVALRHMERCYAKYESQTSFGSMYPTRIEGATRLFCDVYNPQSKTYCKRLQVLCPEHSRDPKVPADEVCGCPLVRDVFELTGDFCRLPKRQCNRHYCWEKLRRAEVDLERVRVWYKLDELFEQERNVRTAMTNRAGLLALMLHQTIQHDPLTTDLRSSADR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGDGSDL -------CCCCCCCC	13.50	-
6	Phosphorylation	--MEGDGSDLEPPDA --CCCCCCCCCCCCC	43.70	26643407
17	Phosphorylation	PPDAGDDSKSENGEN CCCCCCCCCCCCCCC	42.70	24759943
19	Phosphorylation	DAGDDSKSENGENAP CCCCCCCCCCCCCCC	40.00	23684622
28	Phosphorylation	NGENAPIYCICRKPD CCCCCCEEEEECCCC	3.76	23984901
97	Dimethylation	RERDGSERAGSEPRD HCCCCCCCCCCCCCC	46.04	-
100	Phosphorylation	DGSERAGSEPRDEGG CCCCCCCCCCCCCCC	43.36	24453211
103	Dimethylation	ERAGSEPRDEGGGRK CCCCCCCCCCCCCCC	51.03	-
114	Phosphorylation	GGRKRPASDPELQRR CCCCCCCCCHHHHHH	57.28	25266776
124	Phosphorylation	ELQRRAGSGTGVGAM HHHHHCCCCCCHHHH	32.00	27600695
136	Phosphorylation	GAMLARGSASPHKSS HHHHHCCCCCCCCCC	21.74	27717184
138	Phosphorylation	MLARGSASPHKSSPQ HHHCCCCCCCCCCCC	29.27	27087446
142	Phosphorylation	GSASPHKSSPQPLVA CCCCCCCCCCCCCCC	44.19	29472430
143	Phosphorylation	SASPHKSSPQPLVAT CCCCCCCCCCCCCCC	32.15	29472430
150	Phosphorylation	SPQPLVATPSQHHHQ CCCCCCCCCCHHHHH	18.92	25777480
152	Phosphorylation	QPLVATPSQHHHQQQ CCCCCCCCHHHHHHH	37.48	25777480
222	Phosphorylation	RARESYKYFPSSLSP HHHHHHHCCCCCCCC	16.70	27717184
225	Phosphorylation	ESYKYFPSSLSPVTP HHHHCCCCCCCCCCH	33.73	26745281
226	Phosphorylation	SYKYFPSSLSPVTPS HHHCCCCCCCCCCHH	32.86	26745281
228	Phosphorylation	KYFPSSLSPVTPSEA HCCCCCCCCCCHHHC	21.19	26824392
231	Phosphorylation	PSSLSPVTPSEALPR CCCCCCCCHHHCCCC	25.20	26745281
233	Phosphorylation	SLSPVTPSEALPRPR CCCCCCHHHCCCCCC	26.57	23984901
284	Phosphorylation	TATPEPLSDEDLALD CCCCCCCCHHHHCCC	50.06	25338131
591	S-palmitoylation	CRLPKRQCNRHYCWE HHCCHHHCCCHHHHH	5.85	28680068

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CXXC1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CXXC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CXXC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZN768_MOUSE	Zfp768	physical	20211142
HCFC1_HUMAN	HCFC1	physical	26496610
NONO_HUMAN	NONO	physical	26496610
PCCA_HUMAN	PCCA	physical	26496610
RBBP5_HUMAN	RBBP5	physical	26496610
SFPQ_HUMAN	SFPQ	physical	26496610
OGT1_HUMAN	OGT	physical	26496610
ASH2L_HUMAN	ASH2L	physical	26496610
SET1A_HUMAN	SETD1A	physical	26496610
DNJA2_HUMAN	DNAJA2	physical	26496610
ATP5L_HUMAN	ATP5L	physical	26496610
WDR5_HUMAN	WDR5	physical	26496610
WDFY3_HUMAN	WDFY3	physical	26496610
SET1B_HUMAN	SETD1B	physical	26496610
LTMD1_HUMAN	LETMD1	physical	26496610
S35F6_HUMAN	SLC35F6	physical	26496610
AKIP_HUMAN	AURKAIP1	physical	26496610
WDR82_HUMAN	WDR82	physical	26496610
DPY30_HUMAN	DPY30	physical	26496610
BOD1_HUMAN	BOD1	physical	26496610
BD1L1_HUMAN	BOD1L1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.