dbPTM

OCLN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	OCLN_MOUSE
UniProt AC	Q61146
Protein Name	Occludin
Gene Name	Ocln
Organism	Mus musculus (Mouse).
Sequence Length	521
Subcellular Localization	Cell membrane Multi-pass membrane protein . Cell junction, tight junction .
Protein Description	May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier..
Protein Sequence	MSVRPFESPPPYRPDEFKPNHYAPSNDMYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIFACVASTLAWDRGYGTGLFGGSLNYPYSGFGYGGGYGGGYGGYGYGYGGYTDPRAAKGFLLAMAAFCFIASLVIFVTSVIRSGMSRTRRYYLIVIIVSAILGIMVFIATIVYIMGVNPTAQASGSMYGSQIYMICNQFYTPGGTGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIFFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVKNVSAGTQDMPPPPSDYAERVDSPMAYSSNGKVNGKRSYPESFYKSTPLVPEVAQEIPLTLSVDDFRQPRYSSNGNLETPSKRAPTKGKAGKGKRTDPDHYETDYTTGGESCEELEEDWVREYPPITSDQQRQLYKRNFDAGLQEYKSLQAELDDVNKELSRLDKELDDYREESEEYMAAADEYNRLKQVKGSADYKSKRNYCKQLKSKLSHIKRMVGDYDRRKP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSVRPFESP ------CCCCCCCCC	27.17	23375375
8	Phosphorylation	MSVRPFESPPPYRPD CCCCCCCCCCCCCCC	42.98	23375375
40	Phosphorylation	MHVRPMLSQPAYSFY CCCCCCCCCCCCCCC	28.06	29472430
44	Phosphorylation	PMLSQPAYSFYPEDE CCCCCCCCCCCCHHH	13.14	29472430
45	Phosphorylation	MLSQPAYSFYPEDEI CCCCCCCCCCCHHHH	22.02	29472430
47	Phosphorylation	SQPAYSFYPEDEILH CCCCCCCCCHHHHHE	10.36	29472430
274	Ubiquitination	RKMDRYDKSNILWDK HCCCCCCCCCCCCCH	36.15	-
285	Phosphorylation	LWDKEHIYDEQPPNV CCCHHHCCCCCCCCH	18.48	-
297	Ubiquitination	PNVEEWVKNVSAGTQ CCHHHHHHHHCCCCC	53.34	-
300	Phosphorylation	EEWVKNVSAGTQDMP HHHHHHHCCCCCCCC	30.30	22817900
303	Phosphorylation	VKNVSAGTQDMPPPP HHHHCCCCCCCCCCC	22.55	22817900
311	Phosphorylation	QDMPPPPSDYAERVD CCCCCCCCHHHHHCC	49.37	22817900
313	Phosphorylation	MPPPPSDYAERVDSP CCCCCCHHHHHCCCC	18.07	21183079
319	Phosphorylation	DYAERVDSPMAYSSN HHHHHCCCCCEECCC	17.45	22817900
324	Phosphorylation	VDSPMAYSSNGKVNG CCCCCEECCCCCCCC	14.05	22817900
325	Phosphorylation	DSPMAYSSNGKVNGK CCCCEECCCCCCCCC	36.60	21082442
334	Phosphorylation	GKVNGKRSYPESFYK CCCCCCCCCCHHHHC	48.83	29472430
335	Phosphorylation	KVNGKRSYPESFYKS CCCCCCCCCHHHHCC	18.30	29472430
338	Phosphorylation	GKRSYPESFYKSTPL CCCCCCHHHHCCCCC	29.40	25521595
340	Phosphorylation	RSYPESFYKSTPLVP CCCCHHHHCCCCCCH	17.20	29472430
342	Phosphorylation	YPESFYKSTPLVPEV CCHHHHCCCCCCHHH	24.71	30352176
343	Phosphorylation	PESFYKSTPLVPEVA CHHHHCCCCCCHHHH	19.25	30352176
356	Phosphorylation	VAQEIPLTLSVDDFR HHHHCCCEEEHHHCC	16.19	26239621
358	Phosphorylation	QEIPLTLSVDDFRQP HHCCCEEEHHHCCCC	20.47	26239621
367	Phosphorylation	DDFRQPRYSSNGNLE HHCCCCCCCCCCCCC	24.12	25521595
368	Phosphorylation	DFRQPRYSSNGNLET HCCCCCCCCCCCCCC	20.71	22817900
369	Phosphorylation	FRQPRYSSNGNLETP CCCCCCCCCCCCCCC	39.56	25521595
375	Phosphorylation	SSNGNLETPSKRAPT CCCCCCCCCCCCCCC	35.71	22817900
377	Phosphorylation	NGNLETPSKRAPTKG CCCCCCCCCCCCCCC	42.04	23984901
382	Phosphorylation	TPSKRAPTKGKAGKG CCCCCCCCCCCCCCC	51.98	18187566
397	Phosphorylation	KRTDPDHYETDYTTG CCCCCCCCCCCCCCC	28.09	-
399	Phosphorylation	TDPDHYETDYTTGGE CCCCCCCCCCCCCCC	27.43	22871156
401	Phosphorylation	PDHYETDYTTGGESC CCCCCCCCCCCCCCH	17.39	-
402	Phosphorylation	DHYETDYTTGGESCE CCCCCCCCCCCCCHH	23.06	21183079
403	Phosphorylation	HYETDYTTGGESCEE CCCCCCCCCCCCHHH	36.64	22817900
407	Phosphorylation	DYTTGGESCEELEED CCCCCCCCHHHHHHH	30.06	22817900
466	Phosphorylation	LDKELDDYREESEEY HHHHHHHHHHHHHHH	21.42	22817900
470	Phosphorylation	LDDYREESEEYMAAA HHHHHHHHHHHHHHH	30.86	30482847
473	Phosphorylation	YREESEEYMAAADEY HHHHHHHHHHHHHHH	6.49	22817900
480	Phosphorylation	YMAAADEYNRLKQVK HHHHHHHHHHHHHHC	13.21	30482847
489	Phosphorylation	RLKQVKGSADYKSKR HHHHHCCCCCHHHHH	16.55	-
507	Phosphorylation	KQLKSKLSHIKRMVG HHHHHHHHHHHHHHC	27.23	18187566

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
338	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
338	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
338	S	Phosphorylation	Kinase	PKC	-	Uniprot
382	T	Phosphorylation	Kinase	GRK1	Q15835	PSP
402	T	Phosphorylation	Kinase	PRKCH	P23298	Uniprot
507	S	Phosphorylation	Kinase	GRK1	Q15835	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of OCLN_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of OCLN_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TGFR1_MOUSE	Tgfbr1	physical	15761153
CLH1_MOUSE	Cltc	physical	20682309

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of OCLN_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Protein kinase C regulates the phosphorylation and cellularlocalization of occludin."; Andreeva A.Y., Krause E., Mueller E.-C., Blasig I.E.,Utepbergenov D.I.; J. Biol. Chem. 276:38480-38486(2001). Cited for: PHOSPHORYLATION AT SER-338, AND MASS SPECTROMETRY.	11502742 [Abstract]