ETV6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ETV6_MOUSE
• UniProt AC: P97360
• Protein Name: Transcription factor ETV6
• Gene Name: Etv6
• Organism: Mus musculus (Mouse).
• Sequence Length: 485
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation..
• Protein Sequence: MSETPAQSSIKQERISYTPPESPVASHRSSTPLHVHTVPRALRMEEDSIHLPTHLRLQPIYWSRDDVAQWLKWAENEFSLRPIESNKFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKSRMLFSPFFPPGDSIHTKPEVLLHQNHDEDNCVQRTPRTPAESVHHNPPTIELLHRPRSPITTNHRPSPDPEQQRPQRSPLDNMSRRLSPVEKAQGPRLQQENNHQETYPLSVSPVENNHCLPSSPWQESTRVIQLMPSPIMHPLILNPRHSHSVDFKQSRHSEDGMNREGKPINLSHREDLAYLNHIMVSMSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEHLESQVLDEQTYQEDEPTIASPVGWPRGNLPTGTAGGVMEAGELGVAVKEETRE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MSETPAQSSIKQERI CCCCCCCCCCCCCCC	35.82	29176673
9	Phosphorylation	SETPAQSSIKQERIS CCCCCCCCCCCCCCC	23.02	29176673
11	Acetylation	TPAQSSIKQERISYT CCCCCCCCCCCCCCC	48.32	22826441
16	Phosphorylation	SIKQERISYTPPESP CCCCCCCCCCCCCCC	29.22	27087446
17	Phosphorylation	IKQERISYTPPESPV CCCCCCCCCCCCCCC	22.39	27742792
18	Phosphorylation	KQERISYTPPESPVA CCCCCCCCCCCCCCC	26.10	27087446
22	Phosphorylation	ISYTPPESPVASHRS CCCCCCCCCCCCCCC	30.37	27087446
26	Phosphorylation	PPESPVASHRSSTPL CCCCCCCCCCCCCCC	21.48	27742792
29	Phosphorylation	SPVASHRSSTPLHVH CCCCCCCCCCCCEEE	32.89	25266776
30	Phosphorylation	PVASHRSSTPLHVHT CCCCCCCCCCCEEEC	33.72	25266776
31	Phosphorylation	VASHRSSTPLHVHTV CCCCCCCCCCEEECC	30.99	25521595
48	Phosphorylation	ALRMEEDSIHLPTHL CCCCCCCCCCCCCCE	18.39	28066266
53	Phosphorylation	EDSIHLPTHLRLQPI CCCCCCCCCEECCCC	39.64	28066266
61	Phosphorylation	HLRLQPIYWSRDDVA CEECCCCCCCHHHHH	12.19	-
115	Phosphorylation	PHSGDVLYELLQHIL CCCHHHHHHHHHHHH	12.36	-
162	Phosphorylation	EDNCVQRTPRTPAES CCCCCCCCCCCCHHH	10.46	21082442
165	Phosphorylation	CVQRTPRTPAESVHH CCCCCCCCCHHHCCC	28.23	21743459
176	Phosphorylation	SVHHNPPTIELLHRP HCCCCCCCEEEECCC	28.48	27717184
185	Phosphorylation	ELLHRPRSPITTNHR EEECCCCCCCCCCCC	24.28	26824392
188	Phosphorylation	HRPRSPITTNHRPSP CCCCCCCCCCCCCCC	25.57	22802335
189	Phosphorylation	RPRSPITTNHRPSPD CCCCCCCCCCCCCCC	29.73	23684622
194	Phosphorylation	ITTNHRPSPDPEQQR CCCCCCCCCCHHHCC	41.72	23684622
205	Phosphorylation	EQQRPQRSPLDNMSR HHCCCCCCCCCHHHH	25.27	27742792
215	Phosphorylation	DNMSRRLSPVEKAQG CHHHHHCCHHHHHCC	25.70	27087446
234	Phosphorylation	QENNHQETYPLSVSP CCCCCCCCCCCCCCC	24.70	25619855
235	Phosphorylation	ENNHQETYPLSVSPV CCCCCCCCCCCCCCC	11.04	25619855
238	Phosphorylation	HQETYPLSVSPVENN CCCCCCCCCCCCCCC	18.95	27087446
240	Phosphorylation	ETYPLSVSPVENNHC CCCCCCCCCCCCCCC	21.61	25521595
250	Phosphorylation	ENNHCLPSSPWQEST CCCCCCCCCCCCCCC	35.76	21082442
251	Phosphorylation	NNHCLPSSPWQESTR CCCCCCCCCCCCCCC	28.37	25168779
256	Phosphorylation	PSSPWQESTRVIQLM CCCCCCCCCCEEEEC	13.35	25619855
257	Phosphorylation	SSPWQESTRVIQLMP CCCCCCCCCEEEECC	28.36	25619855
265	Phosphorylation	RVIQLMPSPIMHPLI CEEEECCCCCCCCEE	17.06	26824392
280	Phosphorylation	LNPRHSHSVDFKQSR CCCCCCCCCCCCCCC	26.79	27149854
298	Acetylation	DGMNREGKPINLSHR CCCCCCCCCCCCCHH	37.66	-
303	Phosphorylation	EGKPINLSHREDLAY CCCCCCCCHHHHHHH	18.93	23649490
310	Phosphorylation	SHREDLAYLNHIMVS CHHHHHHHHCCEEHH	18.48	26060331
317	Phosphorylation	YLNHIMVSMSPPEEH HHCCEEHHCCCCHHH	9.00	26643407
319	Phosphorylation	NHIMVSMSPPEEHAM CCEEHHCCCCHHHCC	29.78	26643407
342	Phosphorylation	RLLWDYVYQLLSDSR HHHHHHHHHHHCCCC	6.29	-
391	Phosphorylation	NMTYEKMSRALRHYY CCCHHHHHHHHHHHH	26.01	28059163
397	Phosphorylation	MSRALRHYYKLNIIR HHHHHHHHHHHCEEE	8.89	-
398	Phosphorylation	SRALRHYYKLNIIRK HHHHHHHHHHCEEEC	11.68	-
418	Phosphorylation	LLFRFMKTPDEIMSG EEEEECCCHHHHHCC	24.96	-
442	Phosphorylation	SQVLDEQTYQEDEPT HHHCCCCCCCCCCCC	25.73	21149613
443	Phosphorylation	QVLDEQTYQEDEPTI HHCCCCCCCCCCCCC	15.03	21149613
449	Phosphorylation	TYQEDEPTIASPVGW CCCCCCCCCCCCCCC	27.42	23984901
452	Phosphorylation	EDEPTIASPVGWPRG CCCCCCCCCCCCCCC	19.10	21149613

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ETV6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ETV6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ETV6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAT5_MOUSE	Kat5	physical	17980166
KAT6B_MOUSE	Kat6b	physical	17980166

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, AND MASSSPECTROMETRY.
PubMed: 17242355