KAT6B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KAT6B_MOUSE
• UniProt AC: Q8BRB7
• Protein Name: Histone acetyltransferase KAT6B
• Gene Name: Kat6b
• Organism: Mus musculus (Mouse).
• Sequence Length: 1872
• Subcellular Localization: Nucleus .
• Protein Description: Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (By similarity). Involved in cerebral cortex development..
• Protein Sequence: MVKLANPLYTEWILEAVQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGTFPKPTKGSKGPPCNDLRNVDWNKLLKRAIEGLEEPNGSSLKNIEKYLRSQSDLTGTTNHPAFQQRLRLGAKRAVNNGRLLKEGPQYRVNSGSSDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTANVKALRWQCIECKTCSACRVQGKNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVTSDEGSMSAFTGRGSPGRGQKTKVSTTPSSGHAASGKHSSSRLAVTDPTRPGATTKTTTSSTYISASTLKVNKKTKGLIDGLTKFFTPSPDGRRSRGEIIDFSKHYRPRKKVSQKQSCTSHVLATDTDIKISIKQESADVSLVGNKELVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYPQEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQHQRQGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYLYRHHERHISIKAISRATGMCPHDIATTLQHLHMIDRRDGRFVIIRREKLILGHMEKLKNCSRPNELDPESLRWTPMLISNAVVSEEEREAEKEAERLMEQASCWEKEEQEILSSRVSSRQSSAKVQSKNKYLHSPERRPVAGERGQLLELSKESSEEEEEEEEEDDEEEEEEEEEESIQTSPPRLTKPQSVSIKRKRPFVVKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPQLEPTCEIPVEEGGRKPVLRKAFPHQPGKKRQTEEEEGEDNHFFKTAALCRKDVDDDAEHLKEGSKDNPEPLKCRQVWPKGAKRGLSKWKQSKERKTGFKLNLYTPPETPMEPEDQVTIEEQKELSEDKGSPVGMEREVTETVDALLPQEGSRREETGIPVSPHKSPGGKVDEEDLIRGEEEGEEEGEEEGEREEQEEEEEVTTEKDLDGAKSKENPEPEISMEKEDPVHLGDHEEDEDEEEEPSHNEDHDADDEDDGHMEAANMERGDLPRETFKDALEGQEAFLDLSIQPSHSNPEVLMNCGVDLTMSCNSEPKELAGDTGTAPESDAEPPEEQTQKQDQKNSDGVDAELEEGGPAAVEIDSETAQAVQSLTQENREHDDTFPDCAETQEACRSLQNYTHTDQSPQIATTLDECQQSDHSSPVSSVHSHPGQSVRSVNSPSVPALENSYAQISPDQTAITVPPLQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNGSSQNSCSYSSLTSSNLTQNSCAVTQQMSNISGSCSMLQQTSISSPPTCSVKSPQGCVVERPPSSSQQLAQCSMAANFTPPMQLADIPETSNANIGLYERMGQSDFGAGHYPQPSATFSLAKLQQLTNTLIDHSLPYSHSAAVTSYANSASLSTPLSNTGLVQLSQSPHSVPGGPQAQATMTPPPNLTPPPMNLPPPLLQRNMAASNIGISHSQRLQTQIASKGHVSMRTKAASLSPAAATHQSQIYGRSQTVAMQGPARTLTMQRGMNMSVNLMPAPAYNVNSVNMNMNTLNAMNGYSMSQPMMNSGYHSNHGYMNQTPQYPMQMQMGMMGSQPYAQQPMQTPPHANMMYTAPGHHGYMNTGMSKQSLNGSYMRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	VKLANPLYTEWILEA CCCCCHHHHHHHHHH	12.13	29514104
136	Phosphorylation	NIEKYLRSQSDLTGT HHHHHHHHCCCCCCC	31.29	30635358
138	Phosphorylation	EKYLRSQSDLTGTTN HHHHHHCCCCCCCCC	35.52	30635358
141	Phosphorylation	LRSQSDLTGTTNHPA HHHCCCCCCCCCCHH	37.16	30635358
143	Phosphorylation	SQSDLTGTTNHPAFQ HCCCCCCCCCCHHHH	21.13	30635358
144	Phosphorylation	QSDLTGTTNHPAFQQ CCCCCCCCCCHHHHH	32.64	30635358
356	Phosphorylation	KLKQRLLSVTSDEGS HHHHHHHEEECCCCC	28.13	-
359	Phosphorylation	QRLLSVTSDEGSMSA HHHHEEECCCCCCCC	31.35	22006019
380	Acetylation	PGRGQKTKVSTTPSS CCCCCCCEEECCCCC	41.02	23806337
384	Phosphorylation	QKTKVSTTPSSGHAA CCCEEECCCCCCCCC	17.42	26643407
386	Phosphorylation	TKVSTTPSSGHAASG CEEECCCCCCCCCCC	47.03	26643407
387	Phosphorylation	KVSTTPSSGHAASGK EEECCCCCCCCCCCC	35.48	26643407
392	Phosphorylation	PSSGHAASGKHSSSR CCCCCCCCCCCCCCC	49.51	26643407
394	Acetylation	SGHAASGKHSSSRLA CCCCCCCCCCCCCEE	37.51	23806337
396	Phosphorylation	HAASGKHSSSRLAVT CCCCCCCCCCCEEEC	33.23	26643407
397	Phosphorylation	AASGKHSSSRLAVTD CCCCCCCCCCEEECC	21.13	26643407
398	Phosphorylation	ASGKHSSSRLAVTDP CCCCCCCCCEEECCC	34.04	26643407
413	Acetylation	TRPGATTKTTTSSTY CCCCCCCCCCCCCEE	39.25	23806337
441	Acetylation	GLIDGLTKFFTPSPD CCCCHHHHCCCCCCC	43.45	23806337
444	Phosphorylation	DGLTKFFTPSPDGRR CHHHHCCCCCCCCCC	26.45	28066266
446	Phosphorylation	LTKFFTPSPDGRRSR HHHCCCCCCCCCCCC	32.34	28066266
470	Phosphorylation	YRPRKKVSQKQSCTS CCCCCCCCCCCCCCC	40.31	25777480
474	Phosphorylation	KKVSQKQSCTSHVLA CCCCCCCCCCCCEEE	26.80	25777480
476	Phosphorylation	VSQKQSCTSHVLATD CCCCCCCCCCEEECC	27.41	25777480
477	Phosphorylation	SQKQSCTSHVLATDT CCCCCCCCCEEECCC	18.87	25777480
633	Acetylation	AKLFLDHKTLYYDVE HHHHCCCCCEECCCH	39.63	-
636	Phosphorylation	FLDHKTLYYDVEPFL HCCCCCEECCCHHHE	11.67	-
645	Phosphorylation	DVEPFLFYVLTKNDE CCHHHEEEEEECCCC	9.19	-
663	Acetylation	HLVGYFSKEKLCQQK EEEEEECHHHHHHCC	49.31	19861591
707	Phosphorylation	RREGQAGSPEKPLSD CCCCCCCCCCCCHHH	32.66	28066266
816	Phosphorylation	LISNAVVSEEEREAE HHHCCCCCHHHHHHH	32.46	29514104
856	Acetylation	SSRQSSAKVQSKNKY HHCCCCHHHHCCCCC	42.63	23806337
860	Acetylation	SSAKVQSKNKYLHSP CCHHHHCCCCCCCCC	40.13	23806337
862	Acetylation	AKVQSKNKYLHSPER HHHHCCCCCCCCCCC	53.58	-
863	Phosphorylation	KVQSKNKYLHSPERR HHHCCCCCCCCCCCC	21.02	27717184
866	Phosphorylation	SKNKYLHSPERRPVA CCCCCCCCCCCCCCC	26.34	26824392
912	Phosphorylation	EEEESIQTSPPRLTK HHHHHHCCCCCCCCC	41.34	27087446
913	Phosphorylation	EEESIQTSPPRLTKP HHHHHCCCCCCCCCC	19.28	27087446
918	Phosphorylation	QTSPPRLTKPQSVSI CCCCCCCCCCCEECC	41.79	25338131
919	Acetylation	TSPPRLTKPQSVSIK CCCCCCCCCCEECCC	45.73	23806337
922	Phosphorylation	PRLTKPQSVSIKRKR CCCCCCCEECCCCCC	26.76	25338131
934	Acetylation	RKRPFVVKKKRGRKR CCCCCEEEECCCCCC	47.47	22902405
1079	Phosphorylation	GFKLNLYTPPETPME CCEEEEECCCCCCCC	35.22	30482847
1100	Phosphorylation	IEEQKELSEDKGSPV HHHHHHHHCCCCCCC	44.86	28066266
1105	Phosphorylation	ELSEDKGSPVGMERE HHHCCCCCCCCCCHH	23.35	25521595
1131	Phosphorylation	EGSRREETGIPVSPH CCCCCCCCCCCCCCC	35.34	28066266
1136	Phosphorylation	EETGIPVSPHKSPGG CCCCCCCCCCCCCCC	18.88	25159016
1140	Phosphorylation	IPVSPHKSPGGKVDE CCCCCCCCCCCCCCH	26.24	25159016
1296	Phosphorylation	PKELAGDTGTAPESD CHHHCCCCCCCCCCC	35.20	30635358
1298	Phosphorylation	ELAGDTGTAPESDAE HHCCCCCCCCCCCCC	40.92	26643407
1302	Phosphorylation	DTGTAPESDAEPPEE CCCCCCCCCCCCCHH	40.85	21149613
1311	Phosphorylation	AEPPEEQTQKQDQKN CCCCHHHHHHHHHHC	40.80	20469934
1676	Phosphorylation	GGPQAQATMTPPPNL CCCCCCCCCCCCCCC	14.97	-
1678	Phosphorylation	PQAQATMTPPPNLTP CCCCCCCCCCCCCCC	28.43	-
1684	Phosphorylation	MTPPPNLTPPPMNLP CCCCCCCCCCCCCCC	40.15	-
1718	Phosphorylation	RLQTQIASKGHVSMR HHHHHHHHCCCCCHH	40.58	29895711
1723	Phosphorylation	IASKGHVSMRTKAAS HHHCCCCCHHHHCCC	9.25	-
1726	Phosphorylation	KGHVSMRTKAASLSP CCCCCHHHHCCCCCH	19.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KAT6B_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
633	K	Acetylation	Autoacetylation at Lys-633 is required for proper function.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KAT6B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KAT6B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.