FCHO1_MOUSE - dbPTM
FCHO1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FCHO1_MOUSE
UniProt AC Q8K285
Protein Name F-BAR domain only protein 1
Gene Name Fcho1
Organism Mus musculus (Mouse).
Sequence Length 873
Subcellular Localization Membrane, clathrin-coated pit
Peripheral membrane protein
Cytoplasmic side. Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similar
Protein Description Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors (By similarity)..
Protein Sequence MSYFGEHFWGDKNHGFEVLYHCVKQGPVATKELADFIRERANIEETYSKAMAKLSKLASNGTPMGTFAPLWEVFRVSSDKLALCHLELTRKLHDLLKDVLRYGEEQLKTHKKCKEEVLGTVDAVQMLSGVGQLLPKSRENYLSRCMDLERLRRENTSQKEMDKAETKSKKAADSLRRSVDKYNSARADFEIKMLDSALRFQAMEEAHLQHMKALLGSYAHSVEDTHVQIGQVHEEFKQNVENVTVDMLLRKFAESKGTGREKPGPLDFDAYSSAALQEAMKRLRGAKAFRLPGLSRREPRASVDFLESDSGVPPEVDDEGFTVRPDISQNNGAEPPRFSSSDSDFDDEEPRKFYVHIKPAPTRAVACSSEAAAAQLRATAGSLILPPGPGGTMKRHSSRDTSGKPQRPRSAPRTGSCAEKPLASEEPLSKSLFGPPLESAFDHDDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSPSHAAPGPSPESWVPRPGTPQSPPTCRAQHPEPRGLMPRAPSPGPWGPEGGADSLTPADPTREGLAATLRRPRSRKVSCPLTRSNGDLCRSLSPSPLGSSAPTIPPDRPSFSTQMGHGISRGPSPVVLGSQDALPVATAFTEYVHAYFRGHSPSCLARVTGELTMTFPAGIVRVFSGTPPPPVLSFRLVNTAPVEHFQPNADLIFSDPSQSDPETKDFWLNMAALTEALQHQAEQNPTASYYNLVLLRYQFSRPGPESVPLQMSAHWQCGPTLTRVSVEYSYRAGATAVSTPLTNVQILLPVGEPVTSVRLQPAATWNTEEKRFTWKLPDVCEAGGSGHLSASWQPQSGPSTPSPVAAQFTSEGATLSGLDLELLGGGYRMSLVKRRFATGMYLVSC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
182PhosphorylationLRRSVDKYNSARADF
HHHHHHHHHHHHHHH		15.1922817900
184PhosphorylationRSVDKYNSARADFEI
HHHHHHHHHHHHHHH		18.9522817900
295PhosphorylationAFRLPGLSRREPRAS
HHCCCCCCCCCCCCC		34.90-
340PhosphorylationAEPPRFSSSDSDFDD
CCCCCCCCCCCCCCC		35.1428833060
341PhosphorylationEPPRFSSSDSDFDDE
CCCCCCCCCCCCCCC		39.6828833060
343PhosphorylationPRFSSSDSDFDDEEP
CCCCCCCCCCCCCCC		41.9728833060
368PhosphorylationPTRAVACSSEAAAAQ
CCCEEECCCHHHHHH		22.83-
379PhosphorylationAAAQLRATAGSLILP
HHHHHHHHCCCCCCC		25.7225777480
382PhosphorylationQLRATAGSLILPPGP
HHHHHCCCCCCCCCC		15.1225777480
392PhosphorylationLPPGPGGTMKRHSSR
CCCCCCCCCCCCCCC		25.9925266776
414PhosphorylationRPRSAPRTGSCAEKP
CCCCCCCCCCCCCCC		32.1825266776
416PhosphorylationRSAPRTGSCAEKPLA
CCCCCCCCCCCCCCC		15.0025266776
498PhosphorylationPRPGTPQSPPTCRAQ
CCCCCCCCCCCHHCC		33.7728066266
501PhosphorylationGTPQSPPTCRAQHPE
CCCCCCCCHHCCCCC		20.2928066266
518PhosphorylationGLMPRAPSPGPWGPE
CCCCCCCCCCCCCCC		41.3121082442
530PhosphorylationGPEGGADSLTPADPT
CCCCCCCCCCCCCCC		33.3428833060
554PhosphorylationRPRSRKVSCPLTRSN
CCCCCCCCCCCCCCC		17.0428833060
567PhosphorylationSNGDLCRSLSPSPLG
CCCCCHHCCCCCCCC		32.0022817900
600PhosphorylationHGISRGPSPVVLGSQ
CCCCCCCCCEEECCC		32.9026643407
628PhosphorylationHAYFRGHSPSCLARV
HHHHCCCCHHHHHHC		22.7229899451
630PhosphorylationYFRGHSPSCLARVTG
HHCCCCHHHHHHCCC		25.4429899451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FCHO1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FCHO1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FCHO1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of FCHO1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FCHO1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-182 AND SER-184, ANDMASS SPECTROMETRY.

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