CDK14_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDK14_MOUSE
• UniProt AC: O35495
• Protein Name: Cyclin-dependent kinase 14
• Gene Name: Cdk14
• Organism: Mus musculus (Mouse).
• Sequence Length: 469
• Subcellular Localization: Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Recruited to the cell membrane by CCNY..
• Protein Description: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport (By similarity)..
• Protein Sequence: MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKEDTTFDEICVTKMSTRNCQGTDSVIKHLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKSSSAGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTVYSSKSLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	KMKKLRRTLSESFSR HHHHHHHHHHHHHHH	28.36	23527152
24	Phosphorylation	KKLRRTLSESFSRIA HHHHHHHHHHHHHHH	30.49	23527152
26	Phosphorylation	LRRTLSESFSRIALK HHHHHHHHHHHHHHC	25.75	26745281
28	Phosphorylation	RTLSESFSRIALKKE HHHHHHHHHHHHCCC	31.86	27149854
57	Phosphorylation	RNCQGTDSVIKHLDT CCCCCCHHHHHCHHC	26.11	29899451
76	Phosphorylation	KKVRVQRTQSTFDPF CCEECCCCCCCCCCC	15.13	28725479
78	Phosphorylation	VRVQRTQSTFDPFEK EECCCCCCCCCCCCC	30.35	26824392
79	Phosphorylation	RVQRTQSTFDPFEKP ECCCCCCCCCCCCCC	23.41	23684622
95	Phosphorylation	NQVKRVHSENNACIN HHCCCHHCCCCEEEE	38.88	25521595
107	Phosphorylation	CINFKSSSAGKESPK EEEEECCCCCCCCCC	48.40	29514104
112	Phosphorylation	SSSAGKESPKVRRHS CCCCCCCCCCCCCCC	33.24	24899341
119	Phosphorylation	SPKVRRHSSPSSPTS CCCCCCCCCCCCCCC	41.98	21930439
120	Phosphorylation	PKVRRHSSPSSPTSP CCCCCCCCCCCCCCC	23.75	26824392
122	Phosphorylation	VRRHSSPSSPTSPKF CCCCCCCCCCCCCCC	51.39	27087446
123	Phosphorylation	RRHSSPSSPTSPKFG CCCCCCCCCCCCCCC	35.26	27087446
125	Phosphorylation	HSSPSSPTSPKFGKA CCCCCCCCCCCCCCC	60.66	29899451
126	Phosphorylation	SSPSSPTSPKFGKAD CCCCCCCCCCCCCCC	29.49	23684622
134	Phosphorylation	PKFGKADSYEKLEKL CCCCCCCCHHHHHHH	39.80	18388127
135	Phosphorylation	KFGKADSYEKLEKLG CCCCCCCHHHHHHHC	20.03	26160508
145	Phosphorylation	LEKLGEGSYATVYKG HHHHCCCCCEEEEEC	13.80	22817900
146	Phosphorylation	EKLGEGSYATVYKGK HHHCCCCCEEEEECC	19.69	22817900
271	Ubiquitination	ISDTGELKLADFGLA ECCCCCEEEHHHCCC	37.01	-
420	Phosphorylation	ALSHEYFSDLPPRLW HHCHHHHHCCCHHHH	37.02	-
459	Phosphorylation	RAFGKNNSYGKSLSN HHHCCCCCCCCCCCC	44.66	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDK14_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDK14_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDK14_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CDK14_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.