ANS4B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANS4B_HUMAN
• UniProt AC: Q8N8V4
• Protein Name: Ankyrin repeat and SAM domain-containing protein 4B {ECO:0000305}
• Gene Name: ANKS4B {ECO:0000312|HGNC:HGNC:26795}
• Organism: Homo sapiens (Human).
• Sequence Length: 417
• Subcellular Localization: Cell projection, microvillus . Localizes at the tip of microvilli (PubMed:26812018). May associate with endoplasmic reticulum membranes (By similarity).
• Protein Description: As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex. [PubMed: 26812018 May play a role in cellular response to endoplasmic reticulum stress (By similarity]
• Protein Sequence: MSTRYHQAASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKEESGTLSSSKGTFSRSSPSNASAPGTFGSLSKGIKDTFKIKFKKNKDTAEQVGKEGRSGQRNVMEVFREEEEDSFSGDFKEKLQLSAEEDGSVHHESILNRPGLGSIVFRRNRISSPEDISDSKREFGFKLPSELLQRQGASEADEGAADEEGEENGLKDDLPWDDDEVEWEEDVVDATPLEVFLLSQHLEEFLPIFKREQIDLEALLLCSDEDLQSIQMQLGPRKKVLNAINRRKQVLQQPGQLVDTSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTRYHQAA ------CCHHHHHHH	22.92	23663014
3	Phosphorylation	-----MSTRYHQAAS -----CCHHHHHHHC	33.67	23663014
5	Phosphorylation	---MSTRYHQAASDS ---CCHHHHHHHCHH	9.81	23663014
10	Phosphorylation	TRYHQAASDSYLELL HHHHHHHCHHHHHHH	30.06	23663014
12	Phosphorylation	YHQAASDSYLELLKE HHHHHCHHHHHHHHH	29.17	23663014
13	Phosphorylation	HQAASDSYLELLKEA HHHHCHHHHHHHHHH	14.80	23663014
148	Methylation	KNARRQIKECERLQE HHHHHHHHHHHHHHH	48.23	-
156	Methylation	ECERLQEKHQNKMAH HHHHHHHHHHHCCCC	37.21	-
164	Phosphorylation	HQNKMAHTYSKEESG HHHCCCCCCCHHHCC	21.69	23312004
165	Phosphorylation	QNKMAHTYSKEESGT HHCCCCCCCHHHCCC	14.10	46164477
166	Phosphorylation	NKMAHTYSKEESGTL HCCCCCCCHHHCCCC	34.44	23312004
170	Phosphorylation	HTYSKEESGTLSSSK CCCCHHHCCCCCCCC	37.86	23312004
172	Phosphorylation	YSKEESGTLSSSKGT CCHHHCCCCCCCCCE	32.52	23312004
174	Phosphorylation	KEESGTLSSSKGTFS HHHCCCCCCCCCEEC	32.19	23312004
175	Phosphorylation	EESGTLSSSKGTFSR HHCCCCCCCCCEECC	38.90	23312004
176	Phosphorylation	ESGTLSSSKGTFSRS HCCCCCCCCCEECCC	31.56	23312004
183	Phosphorylation	SKGTFSRSSPSNASA CCCEECCCCCCCCCC	45.46	28857561
184	Phosphorylation	KGTFSRSSPSNASAP CCEECCCCCCCCCCC	31.10	46164447
186	Phosphorylation	TFSRSSPSNASAPGT EECCCCCCCCCCCCC	47.15	46164453
189	Phosphorylation	RSSPSNASAPGTFGS CCCCCCCCCCCCCCC	38.97	46164459
193	Phosphorylation	SNASAPGTFGSLSKG CCCCCCCCCCCCCCC	24.62	28857561
196	Phosphorylation	SAPGTFGSLSKGIKD CCCCCCCCCCCCCCC	25.86	26657352
198	Phosphorylation	PGTFGSLSKGIKDTF CCCCCCCCCCCCCCE	30.45	46164465
204	Phosphorylation	LSKGIKDTFKIKFKK CCCCCCCCEEEEECC	23.09	28857561
215	Phosphorylation	KFKKNKDTAEQVGKE EECCCCHHHHHHHCC	33.43	26657352
282	Phosphorylation	VFRRNRISSPEDISD EEECCCCCCHHHCCC	36.28	28857561
283	Phosphorylation	FRRNRISSPEDISDS EECCCCCCHHHCCCH	29.91	26657352
288	Phosphorylation	ISSPEDISDSKREFG CCCHHHCCCHHHHHC	48.42	25841592
290	Phosphorylation	SPEDISDSKREFGFK CHHHCCCHHHHHCCC	27.16	24961811

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:20804422

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANS4B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANS4B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.