| UniProt ID | RHG15_MOUSE | |
|---|---|---|
| UniProt AC | Q811M1 | |
| Protein Name | Rho GTPase-activating protein 15 | |
| Gene Name | Arhgap15 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 481 | |
| Subcellular Localization |
Cytoplasm. Membrane Peripheral membrane protein. |
|
| Protein Description | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction (By similarity).. | |
| Protein Sequence | MEKRTSCSVQTSTNCDNSLEILNSAHQATGAVQMRIKNANSHQDRQSQTKSMILTDAGKVTEPISRHRRNHSQHVLKDVIPPLEHPMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSGRKIEFYKDSKQQALPNMKTRHNVESVDLCGAHIEWAKEKSSRKSVFQITTVSGNEFLLQSDIDFLILDWFQAIKNAIDRLPKNPSCGSLELFNLQRSSSSELPSHCHIDRKEQKPEHRKSFMFRLHHSASDTSDKNRVKSRLKKFISRRPSLKTLQEKGLIKDQIFGSHLHTVCEREHSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFRELSEPLFPYSFFERFVEAIKKQDSNEKIETMRSLVKRLPPPNHDTMKILFRHLTKIVAKASQNLMSTQSLGIVFGPTLLRAENESGNVAVHMVYQNQIAEFMLTEYDKIFSSEED | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 51 | Phosphorylation | DRQSQTKSMILTDAG CHHHHHHHEEECCCC | 17.91 | 28833060 | |
| 72 | Phosphorylation | SRHRRNHSQHVLKDV HHHCCCCCHHHHHHC | 26.07 | 25266776 | |
| 111 | Phosphorylation | KKLRKNWSTSWIVLS CCCCCCCCCEEEEEE | 23.20 | 22817900 | |
| 112 | Phosphorylation | KLRKNWSTSWIVLSG CCCCCCCCEEEEEEC | 21.50 | 22817900 | |
| 113 | Phosphorylation | LRKNWSTSWIVLSGR CCCCCCCEEEEEECC | 14.86 | 19854140 | |
| 128 | Phosphorylation | KIEFYKDSKQQALPN EEEEECCHHHHCCCC | 28.36 | 19854140 | |
| 204 | Phosphorylation | DRLPKNPSCGSLELF HHCCCCCCCCCEEEE | 40.27 | 22942356 | |
| 207 | Phosphorylation | PKNPSCGSLELFNLQ CCCCCCCCEEEEECC | 24.01 | 28833060 | |
| 216 | Phosphorylation | ELFNLQRSSSSELPS EEEECCCCCCCCCCC | 22.93 | 28833060 | |
| 217 | Phosphorylation | LFNLQRSSSSELPSH EEECCCCCCCCCCCC | 39.82 | 28833060 | |
| 218 | Phosphorylation | FNLQRSSSSELPSHC EECCCCCCCCCCCCC | 29.13 | 28833060 | |
| 219 | Phosphorylation | NLQRSSSSELPSHCH ECCCCCCCCCCCCCC | 45.13 | 28833060 | |
| 223 | Phosphorylation | SSSSELPSHCHIDRK CCCCCCCCCCCCCCC | 51.90 | 30635358 | |
| 239 | Phosphorylation | QKPEHRKSFMFRLHH CCHHHHHCCHHHHHC | 23.15 | 24719451 | |
| 247 | Phosphorylation | FMFRLHHSASDTSDK CHHHHHCCCCCCCCH | 20.79 | 25266776 | |
| 249 | Phosphorylation | FRLHHSASDTSDKNR HHHHCCCCCCCCHHH | 44.42 | 25266776 | |
| 251 | Phosphorylation | LHHSASDTSDKNRVK HHCCCCCCCCHHHHH | 36.01 | 30635358 | |
| 252 | Phosphorylation | HHSASDTSDKNRVKS HCCCCCCCCHHHHHH | 52.13 | 30635358 | |
| 270 | Phosphorylation | KFISRRPSLKTLQEK HHHHCCCCHHHHHHC | 40.46 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RHG15_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RHG15_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RHG15_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of RHG15_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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