UBP45_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP45_MOUSE
• UniProt AC: Q8K387
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 45
• Gene Name: Usp45
• Organism: Mus musculus (Mouse).
• Sequence Length: 813
• Protein Sequence: MRVKDPSKDLPEKGKRNKRPLLPHDEDSSDDIAVGLTCQHVSYAVSVNHVKKAVAESLWSVCSECLKERRFCDGQPVLPADVWLCLKCGLQGCGKNSESQHSLRHFKSSGTESHCVVISLSTWVIWCYECNEKLSTHCNKKVLAQIVDFLQKHAFKTQTGAFSRIIKLCEEKREAGEIKKGKKGCTVPSVKGITNLGNTCFFNAVIQNLAQTYILFELMNEIKEDGTKFKISLSSAPQLEPLVVELSSPGPLTSALFLFLHSMKEAEKGPLSPKVLFNQLCQKAPRFKGFQQQDSQELLHHLLDAVRTEETKRIQASILKAFNNPTTKTADDETRKKVKAYGKEGVKMNFIDRIFIGELTSTVMCEECANISTMKDPFIDISLPIIEERVSKPVLLGKMSKCRSLQETDQDHNKGTVTVGNAHQPRASRKHSSPNDKNQLSHDRKHLRKWPSEEEKTVVTHPKNDNLEASPPASTLSTEASLNESLTDGSERDASLESSVDADSEASEPEIASKQPVLLRSRGDSCGHAEQHPHLPLASELPQAKETHGGEEEMAEAIAELHLSGTVTGNRDFHREKQPLNVPNNLCFSEGKHTRLHSAQNAFQTLSQSYVTTSKECSVQSCLYQFTSMELLMGNNKLLCEDCTEKRRKCHKETSSAEKKAGGVYTNARKQLLISAVPAILILHLKRFHQAGLSLRKVNRHVDFPLTLDLAPFCAATCKNISVGEKVLYGLYGIVEHSGSMRGGHYTAYVKVRVPSRKLSECITGRKTAAGLKEPDGELGGHWVHVSDTYVQVVPESRALSAQAYLLFYERIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	LLPHDEDSSDDIAVG CCCCCCCCCCCCEEE	33.35	22817900
29	Phosphorylation	LPHDEDSSDDIAVGL CCCCCCCCCCCEEEC	52.18	22817900
128	Phosphorylation	STWVIWCYECNEKLS ECEEHHHHHCCHHHH	14.44	28576409
337	Ubiquitination	ADDETRKKVKAYGKE CCHHHHHHHHHHCCC	45.75	-
347	Ubiquitination	AYGKEGVKMNFIDRI HHCCCCCCCCEECEE	38.70	-
391	Ubiquitination	PIIEERVSKPVLLGK HHHHHHCCCCCHHHC	37.15	27667366
392	Ubiquitination	IIEERVSKPVLLGKM HHHHHCCCCCHHHCH	35.97	27667366
404	Phosphorylation	GKMSKCRSLQETDQD HCHHHCCCCHHCCCC	43.82	29899451
452	Phosphorylation	KHLRKWPSEEEKTVV HHHHCCCCHHHCCEE	57.43	26824392
457	Phosphorylation	WPSEEEKTVVTHPKN CCCHHHCCEEECCCC	24.40	25159016
470	Phosphorylation	KNDNLEASPPASTLS CCCCCCCCCCCCHHC	23.26	25293948
474	Phosphorylation	LEASPPASTLSTEAS CCCCCCCCHHCCCCH	35.34	25293948
475	Phosphorylation	EASPPASTLSTEASL CCCCCCCHHCCCCHH	27.17	25293948
478	Phosphorylation	PPASTLSTEASLNES CCCCHHCCCCHHCCC	38.39	25293948
485	Phosphorylation	TEASLNESLTDGSER CCCHHCCCCCCCCCC	35.18	25293948
487	Phosphorylation	ASLNESLTDGSERDA CHHCCCCCCCCCCCH	47.82	25293948
490	Phosphorylation	NESLTDGSERDASLE CCCCCCCCCCCHHHH	32.06	25293948
495	Phosphorylation	DGSERDASLESSVDA CCCCCCHHHHHHCCC	36.64	25293948
498	Phosphorylation	ERDASLESSVDADSE CCCHHHHHHCCCCCC	40.74	25293948
499	Phosphorylation	RDASLESSVDADSEA CCHHHHHHCCCCCCC	18.03	25293948
504	Phosphorylation	ESSVDADSEASEPEI HHHCCCCCCCCCCHH	36.46	21183079
507	Phosphorylation	VDADSEASEPEIASK CCCCCCCCCCHHHHC	50.02	22817900
521	Phosphorylation	KQPVLLRSRGDSCGH CCCEEEECCCCCCCC	40.35	26643407
525	Phosphorylation	LLRSRGDSCGHAEQH EEECCCCCCCCHHHC	25.48	16141072
707	Phosphorylation	RHVDFPLTLDLAPFC CCCCCCEECCCHHHH	20.61	25367039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBP45_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBP45_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP45_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of UBP45_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.