ELP3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELP3_MOUSE
• UniProt AC: Q9CZX0
• Protein Name: Elongator complex protein 3
• Gene Name: Elp3
• Organism: Mus musculus (Mouse).
• Sequence Length: 547
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin (By similarity). May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. [PubMed: 19185337]
• Protein Sequence: MRQKRKGDLSPAELMMLTIGDVIKQLVEAHEQGKDVDLNKMKTKTAAKYGLASQPRLVDIIAAVPPHYRKILIPKLKAKPVRTASGIAVVAVMCKPHRCPHISFTGNICIYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFLQTRHRIEQLKQLGHSVDKVEFIVMGGTFMALPEEYRDYFIRSLHDALSGHTSNNIHEAIKYSERSFTKCVGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTNRGHTVKAACESFHLAKDSGFKVVTHMMPDLPNVGLERDIEQFIEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYRSYSPSDLIELVARILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELAFARMKDLGIQCRDVRTREVGIQEIHHRVRPYQVELVRRDYVANGGWETFLSYEDPDQDILIGLLRLRKCSEETFRFELGGGVSIVRELHVYGSVVPVSSRDPTKFQHQGFGMLLMEEAERIAREEHGSGKMAVISGVGTRNYYRKIGYRLQGPYMVKMLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34 (in isoform 2)	Ubiquitination	-	55.03	22790023
34	Ubiquitination	VEAHEQGKDVDLNKM HHHHHCCCCCCHHHH	55.03	22790023
40 (in isoform 2)	Ubiquitination	-	49.42	22790023
40	Ubiquitination	GKDVDLNKMKTKTAA CCCCCHHHHHHHHHH	49.42	22790023
48	Ubiquitination	MKTKTAAKYGLASQP HHHHHHHHHCCCCCC	37.07	22790023
48 (in isoform 2)	Ubiquitination	-	37.07	22790023
53	Phosphorylation	AAKYGLASQPRLVDI HHHHCCCCCCEEHHH	45.84	23737553
53 (in isoform 2)	Ubiquitination	-	45.84	-
59 (in isoform 2)	Ubiquitination	-	31.04	-
67 (in isoform 2)	Ubiquitination	-	29.03	-
161	Phosphorylation	QLKQLGHSVDKVEFI HHHHHCCCCCEEEEE	30.16	22817900
229	Methylation	TRPDYCMKRHLSDML CCCCHHHHHHHHHHH	32.86	-
280	Acetylation	LAKDSGFKVVTHMMP CCCCCCCEEEEEECC	39.04	23236377
329	Phosphorylation	VIRGTGLYELWKSGR EEECCCHHHHHHCCC	15.43	19605366
333	Ubiquitination	TGLYELWKSGRYRSY CCHHHHHHCCCCCCC	56.51	22790023
333 (in isoform 2)	Ubiquitination	-	56.51	22790023
352 (in isoform 2)	Ubiquitination	-	1.58	-
392 (in isoform 2)	Ubiquitination	-	44.22	22790023
392	Ubiquitination	ELAFARMKDLGIQCR HHHHHHHHHHCCEEE	44.22	22790023
411 (in isoform 2)	Ubiquitination	-	1.58	-
470	Phosphorylation	FELGGGVSIVRELHV EEECCCEEEEEEEEE	20.74	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ELP3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELP3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELP3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ELP3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.