RGL3_MOUSE - dbPTM
RGL3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RGL3_MOUSE
UniProt AC Q3UYI5
Protein Name Ral guanine nucleotide dissociation stimulator-like 3
Gene Name Rgl3
Organism Mus musculus (Mouse).
Sequence Length 709
Subcellular Localization
Protein Description Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1..
Protein Sequence MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRSTPERSGEGQTPIPATDTFLHYRTSKVRALRAARLERLVHELVSGDREQDPGFVPAFLATHRAFVPTARVLGFLLPPPPPPPPPPAGVDSKRTEGQDLNFSKNLRAVVSVLGSWLRNHPQDFRDPPDHQNLGNVRIFLGWAAPGGAEAREAEKLLEDFLKEAKGEQTEEEKRLAWSGPPRIAQTPGSEFAEDCVEEEGPSSEGPELLDFSVDDVAEQLTLMDVELFLRVRSCECLGSMWSQRDRPGAAGISPTVRATVAQFNTVTGCVLGSVLAAPGLAASQRAQRIEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSVFRKLSQIFSDEDNHLSSRAILSQEETTEDDDCPSGSLPSKLPPGPVPYLGTFLTDLVMLDTALPDTLKGNLINFEKRRKEWEILARIQQLQQRCQRYSLSPRPPILAALRAQRQLSEEQSYRVSRVIEPPAASCPSSPRIRRRISLTKRLSAKLSREKNSSPGGSPGDPSSPTSSVSPGSPPSSPRNREPPPPGSPPASPGPQSPSTKLSLTMDPPGPWPVTLTPSSSRVPLLGQQTSEARVIRVSINNNHGNLYRSILLTCQDKAPSVVQRALEKHNVPQPWARDYQLFQVLPGDRELLIPDGANVFYAMSPAAPGDFLLRRKEGTGHTLSASPT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
28PhosphorylationTEDGAVYSVSLRRQR
CCCCCEEEEEECCHH		9.9123737553
30PhosphorylationDGAVYSVSLRRQRSQ
CCCEEEEEECCHHHC		15.3727555448
36PhosphorylationVSLRRQRSQRSTPER
EEECCHHHCCCCCCC		22.93-
140UbiquitinationGQDLNFSKNLRAVVS
CCCCCCCHHHHHHHH		56.7322790023
191UbiquitinationAEAREAEKLLEDFLK
HHHHHHHHHHHHHHH		66.4722790023
376UbiquitinationEPLSVFRKLSQIFSD
CHHHHHHHHHHHCCC		40.8122790023
378PhosphorylationLSVFRKLSQIFSDED
HHHHHHHHHHCCCCC		25.0228973931
395PhosphorylationLSSRAILSQEETTED
CCHHHHHCCCCCCCC		29.4528973931
471PhosphorylationQQRCQRYSLSPRPPI
HHHHHHCCCCCCHHH		25.2624719451
473PhosphorylationRCQRYSLSPRPPILA
HHHHCCCCCCHHHHH		16.9626239621
489PhosphorylationLRAQRQLSEEQSYRV
HHHHHHCCHHHHCCC		30.6528973931
506PhosphorylationVIEPPAASCPSSPRI
ECCCCCHHCCCCHHH		28.7725521595
509PhosphorylationPPAASCPSSPRIRRR
CCCHHCCCCHHHHHH		58.2525521595
510PhosphorylationPAASCPSSPRIRRRI
CCHHCCCCHHHHHHH		11.8925521595
518PhosphorylationPRIRRRISLTKRLSA
HHHHHHHHHHHHHHH		28.3326824392
520PhosphorylationIRRRISLTKRLSAKL
HHHHHHHHHHHHHHH		13.8225367039
524PhosphorylationISLTKRLSAKLSREK
HHHHHHHHHHHHHHC		27.6529514104
528PhosphorylationKRLSAKLSREKNSSP
HHHHHHHHHHCCCCC		37.3729514104
533PhosphorylationKLSREKNSSPGGSPG
HHHHHCCCCCCCCCC		49.3221183079
534PhosphorylationLSREKNSSPGGSPGD
HHHHCCCCCCCCCCC		36.6428973931
538PhosphorylationKNSSPGGSPGDPSSP
CCCCCCCCCCCCCCC		31.4629472430
543PhosphorylationGGSPGDPSSPTSSVS
CCCCCCCCCCCCCCC		54.4023140645
544PhosphorylationGSPGDPSSPTSSVSP
CCCCCCCCCCCCCCC		37.2729472430
546PhosphorylationPGDPSSPTSSVSPGS
CCCCCCCCCCCCCCC		35.2726239621
547PhosphorylationGDPSSPTSSVSPGSP
CCCCCCCCCCCCCCC		31.9323140645
548PhosphorylationDPSSPTSSVSPGSPP
CCCCCCCCCCCCCCC		29.1423140645
550PhosphorylationSSPTSSVSPGSPPSS
CCCCCCCCCCCCCCC		26.0326643407
553PhosphorylationTSSVSPGSPPSSPRN
CCCCCCCCCCCCCCC		36.7025521595
556PhosphorylationVSPGSPPSSPRNREP
CCCCCCCCCCCCCCC		57.2521082442
557PhosphorylationSPGSPPSSPRNREPP
CCCCCCCCCCCCCCC		33.3825521595
568PhosphorylationREPPPPGSPPASPGP
CCCCCCCCCCCCCCC		33.2225521595
572PhosphorylationPPGSPPASPGPQSPS
CCCCCCCCCCCCCCC		35.8425521595
577PhosphorylationPASPGPQSPSTKLSL
CCCCCCCCCCCCEEE		24.7727087446
579PhosphorylationSPGPQSPSTKLSLTM
CCCCCCCCCCEEEEC		43.3426239621
580PhosphorylationPGPQSPSTKLSLTMD
CCCCCCCCCEEEECC		39.1126239621
600PhosphorylationPVTLTPSSSRVPLLG
CEEECCCCCCCCCCC		24.30-
700PhosphorylationLLRRKEGTGHTLSAS
EEEECCCCCCCCCCC		27.2123737553
703PhosphorylationRKEGTGHTLSASPT-
ECCCCCCCCCCCCC-		24.6123737553
705PhosphorylationEGTGHTLSASPT---
CCCCCCCCCCCC---		28.0523737553
707PhosphorylationTGHTLSASPT-----
CCCCCCCCCC-----		26.2025521595
709PhosphorylationHTLSASPT-------
CCCCCCCC-------		49.0723737553
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RGL3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RGL3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RGL3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RIT1_MOUSERit1physical
10869344
RASH_MOUSEHrasphysical
10869344
RALB_MOUSERalbphysical
10869344
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RGL3_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-506; SER-510; SER-568AND SER-572, AND MASS SPECTROMETRY.

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