PAR6A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAR6A_RAT
• UniProt AC: Q6B4M5
• Protein Name: Partitioning defective 6 homolog alpha
• Gene Name: Pard6a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 346
• Subcellular Localization: Cytoplasm. Cell membrane. Cell junction, tight junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with GTP-bound CDC42
• Protein Description: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization..
• Protein Sequence: MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRTSVRGFQEFSRLLCVVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEGDSSGLAFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPSSVGPGPTDPDSDDDNSDPVIENRHPPCSNGLSQGPLCWDLQPGCLHPSAGSSLPSLDSREQANSGWGNGMRGDVSGFSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
109	Phosphorylation	GLAFASNSLQRRKKG HHHHHCHHHHHHHCC	24.31	27097102
143	Phosphorylation	PQDFRQVSSVIDVDL CCCHHHHHCCCCHHC	15.56	16641100
154	Phosphorylation	DVDLLPETHRRVRLH CHHCCCCCCCCEEEC	20.81	16641100
172	Phosphorylation	SDRPLGFYIRDGMSV CCCCCEEEEECCCEE	8.02	-
274	Phosphorylation	SSVGPGPTDPDSDDD CCCCCCCCCCCCCCC	67.11	28689409
278	Phosphorylation	PGPTDPDSDDDNSDP CCCCCCCCCCCCCCC	48.61	27097102
283	Phosphorylation	PDSDDDNSDPVIENR CCCCCCCCCCCCCCC	50.73	28551015
345	Phosphorylation	RGDVSGFSL------ CCCCCCCCC------	36.37	28551015

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAR6A_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAR6A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAR6A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PAR6A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.