| UniProt ID | I5P2_MOUSE | |
|---|---|---|
| UniProt AC | Q8K337 | |
| Protein Name | Type II inositol 1,4,5-trisphosphate 5-phosphatase | |
| Gene Name | Inpp5b | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 993 | |
| Subcellular Localization |
Cytoplasm, cytosol . Endoplasmic reticulum-Golgi intermediate compartment . Early endosome membrane . Membrane Peripheral membrane protein Cytoplasmic side . Cytoplasmic vesicle, phagosome membrane . |
|
| Protein Description | Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.. | |
| Protein Sequence | MDQSVAIQETLVEGEYCVIAVQGVLCKGDSRQSRLLGLVRYRLENDAQEHALFLYTHRRMAITGDDVSLDQIVPLSKDFMLEEVSPDGELYILGSDVTVQLNTAELKLVFQLPFGSHTRTFLQEVARACPGFDPETRDPEFEWLSRHTCAEPDAESPKPREWNSDPGTRSGFAPIGGSRHQSRNARRGLEDVLPRGPGYILLWGGAAEEPEFLLAEEMHEGGPVRGRRPLAGRRDEALEEADWEMSAGGGSRERDCAGVSNVDSSRPNGRGPDQPSGARCPEKPENSLTRQNKSKSDMSEKVRSATVTVSDKAHILSVQKFGLRDTIVRSHLVQKEENYTYIQNFRFFVGTYNVNGQSPKECLRPWLSHSALAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSESLHPDAKYAKVKFVRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQLHNTSICVVNSHLAAHTEEYERRNQDYRDICSRMQFPQVDPSQPPLTINKHDVILWLGDLNYRIEELDVGKVKKLVEEKAFQTLYAHDQLKIQVAARTIFDGFTEGEITFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNEELYRKTLEEIVRSLDKMENANIPSVTLSKREFCFENVKYMQLQTESFTIHNSQVPCQFEFINKPDEESYCKQWLTARPSKGFLLPDSHVEIELELFVNKSTATKLNSGKDTIEDILVLHLERGKDYFLSVSGNYLPSCFGSPIHTLCYMREPILDLPLKTVSDLTLMSVQTADDRSQLENPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRPEFDHIRDCLDTGMIDQLCANNHSVAEALLLFLESLPEPVICYSAYHSCLECSGNYAASKQIILTLPSFHKNVFNYLMAFLQELLKNSANNHLDENILASIFGSLLLRNPARHQKLDMAEKKKAQEFIHQFLCGPL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 156 | Phosphorylation | CAEPDAESPKPREWN CCCCCCCCCCCCCCC | 39.69 | 26824392 | |
| 178 | Phosphorylation | GFAPIGGSRHQSRNA CCCCCCCCHHHCHHH | 22.75 | 29514104 | |
| 341 | Phosphorylation | QKEENYTYIQNFRFF CCCCCEEEEEEEEEE | 7.08 | - | |
| 539 | Ubiquitination | IEELDVGKVKKLVEE EEEECHHHHHHHHHH | 51.21 | 22790023 | |
| 614 | Phosphorylation | LWKGKNITQLSYQSH EECCCCHHHHHHHHC | 32.62 | 28576409 | |
| 618 | Phosphorylation | KNITQLSYQSHMALK CCHHHHHHHHCCCCC | 23.72 | 28576409 | |
| 626 | Phosphorylation | QSHMALKTSDHKPVS HHCCCCCCCCCCCCC | 39.99 | 26239621 | |
| 627 | Phosphorylation | SHMALKTSDHKPVSS HCCCCCCCCCCCCCH | 35.81 | 26239621 | |
| 633 | Phosphorylation | TSDHKPVSSVFDIGV CCCCCCCCHHHHEEE | 29.34 | 26239621 | |
| 634 | Phosphorylation | SDHKPVSSVFDIGVR CCCCCCCHHHHEEEE | 27.34 | 26239621 | |
| 990 | Farnesylation | EFIHQFLCGPL---- HHHHHHHHCCC---- | 5.80 | - | |
| 990 | Methylation | EFIHQFLCGPL---- HHHHHHHHCCC---- | 5.80 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of I5P2_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of I5P2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of I5P2_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of I5P2_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
