T3JAM_HUMAN - dbPTM
T3JAM_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID T3JAM_HUMAN
UniProt AC Q9Y228
Protein Name TRAF3-interacting JNK-activating modulator
Gene Name TRAF3IP3
Organism Homo sapiens (Human).
Sequence Length 551
Subcellular Localization Membrane
Single-pass type IV membrane protein .
Protein Description May function as an adapter molecule that regulates TRAF3-mediated JNK activation..
Protein Sequence MISPDPRPSPGLARWAESYEAKCERRQEIRESRRCRPNVTTCRQVGKTLRIQQREQLQRARLQQFFRRRNLELEEKGKAQHPQAREQGPSRRPGQVTVLKEPLSCARRISSPREQVTGTSSEVFPAQHPPPSGICRDLSDHLSSQAGGLPPQDTPIKKPPKHHRGTQTKAEGPTIKNDASQQTNYGVAVLDKEIIQLSDYLKEALQRELVLKQKMVILQDLLSTLIQASDSSWKGQLNEDKLKGKLRSLENQLYTCTQKYSPWGMKKVLLEMEDQKNSYEQKAKESLQKVLEEKMNAEQQLQSTQRSLALAEQKCEEWRSQYEALKEDWRTLGTQHRELESQLHVLQSKLQGADSRDLQMNQALRFLENEHQQLQAKIECLQGDRDLCSLDTQDLQDQLKRSEAEKLTLVTRVQQLQGLLQNQSLQLQEQEKLLTKKDQALPVWSPKSFPNEVEPEGTGKEKDWDLRDQLQKKTLQLQAKEKECRELHSELDNLSDEYLSCLRKLQHCREELNQSQQLPPRRQCGRWLPVLMVVIAAALAVFLANKDNLMI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MISPDPRPSP
-----CCCCCCCCCC		23.1923401153
9PhosphorylationISPDPRPSPGLARWA
CCCCCCCCCCHHHHH		32.6430108239
78UbiquitinationLELEEKGKAQHPQAR
CHHHHCCCCCCCHHH		56.81-
110PhosphorylationLSCARRISSPREQVT
CCCCHHCCCCCHHCC		32.2624247654
111PhosphorylationSCARRISSPREQVTG
CCCHHCCCCCHHCCC		26.1328634298
117PhosphorylationSSPREQVTGTSSEVF
CCCCHHCCCCCCCCC		34.1428634298
119PhosphorylationPREQVTGTSSEVFPA
CCHHCCCCCCCCCCC		21.5128634298
120PhosphorylationREQVTGTSSEVFPAQ
CHHCCCCCCCCCCCC		26.3328634298
121PhosphorylationEQVTGTSSEVFPAQH
HHCCCCCCCCCCCCC		37.3028634298
154PhosphorylationGGLPPQDTPIKKPPK
CCCCCCCCCCCCCCC		22.97-
180PhosphorylationPTIKNDASQQTNYGV
CCCCCCHHHCCCCEE		26.19-
183PhosphorylationKNDASQQTNYGVAVL
CCCHHHCCCCEEEEE		23.8322115753
185PhosphorylationDASQQTNYGVAVLDK
CHHHCCCCEEEEECH		19.1622817900
192UbiquitinationYGVAVLDKEIIQLSD
CEEEEECHHHHHHHH		46.80-
202UbiquitinationIQLSDYLKEALQREL
HHHHHHHHHHHHHHH		34.41-
254PhosphorylationRSLENQLYTCTQKYS
HHHHHHHHHHCHHCC		7.0422817900
255PhosphorylationSLENQLYTCTQKYSP
HHHHHHHHHCHHCCC		20.0522115753
257PhosphorylationENQLYTCTQKYSPWG
HHHHHHHCHHCCCCC		21.9428122231
260PhosphorylationLYTCTQKYSPWGMKK
HHHHCHHCCCCCHHH		15.3322817900
261PhosphorylationYTCTQKYSPWGMKKV
HHHCHHCCCCCHHHH		22.6327080861
267UbiquitinationYSPWGMKKVLLEMED
CCCCCHHHHHHHHHH		29.2617203973
272SulfoxidationMKKVLLEMEDQKNSY
HHHHHHHHHHHCCHH		7.4921406390
276UbiquitinationLLEMEDQKNSYEQKA
HHHHHHHCCHHHHHH		61.25-
294UbiquitinationLQKVLEEKMNAEQQL
HHHHHHHHCCHHHHH		28.25-
295SulfoxidationQKVLEEKMNAEQQLQ
HHHHHHHCCHHHHHH		6.9421406390
314UbiquitinationSLALAEQKCEEWRSQ
HHHHHHHHHHHHHHH		34.81-
320PhosphorylationQKCEEWRSQYEALKE
HHHHHHHHHHHHHHH		37.8822115753
322PhosphorylationCEEWRSQYEALKEDW
HHHHHHHHHHHHHHH		12.3828796482
326UbiquitinationRSQYEALKEDWRTLG
HHHHHHHHHHHHHHH		61.75-
349UbiquitinationQLHVLQSKLQGADSR
HHHHHHHHHCCCCHH		31.69-
349AcetylationQLHVLQSKLQGADSR
HHHHHHHHHCCCCHH		31.6925953088
360SulfoxidationADSRDLQMNQALRFL
CCHHHHHHHHHHHHH		5.3621406390
377UbiquitinationEHQQLQAKIECLQGD
HHHHHHHHHHHHHCC		26.52-
400UbiquitinationQDLQDQLKRSEAEKL
HHHHHHHHHHHHHHH		48.52-
406UbiquitinationLKRSEAEKLTLVTRV
HHHHHHHHHHHHHHH		54.54-
445PhosphorylationDQALPVWSPKSFPNE
HHCCCCCCCCCCCCC		23.7622115753
447UbiquitinationALPVWSPKSFPNEVE
CCCCCCCCCCCCCCC		60.25-
448PhosphorylationLPVWSPKSFPNEVEP
CCCCCCCCCCCCCCC		49.6926074081
462UbiquitinationPEGTGKEKDWDLRDQ
CCCCCCCCCCCHHHH		68.55-
472UbiquitinationDLRDQLQKKTLQLQA
CHHHHHHHHHHHHHH		57.21-
473UbiquitinationLRDQLQKKTLQLQAK
HHHHHHHHHHHHHHH		41.32-
480UbiquitinationKTLQLQAKEKECREL
HHHHHHHHHHHHHHH		57.25-
498PhosphorylationLDNLSDEYLSCLRKL
HHHCCHHHHHHHHHH		14.6527642862
500PhosphorylationNLSDEYLSCLRKLQH
HCCHHHHHHHHHHHH		15.3724719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of T3JAM_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of T3JAM_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of T3JAM_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
2AAA_HUMANPPP2R1Aphysical
18782753
PP2AA_HUMANPPP2CAphysical
18782753
STRN_HUMANSTRNphysical
18782753
STRP1_HUMANSTRIP1physical
18782753
STRN3_HUMANSTRN3physical
18782753
STRN4_HUMANSTRN4physical
18782753
STK24_HUMANSTK24physical
18782753
PHOCN_HUMANMOB4physical
18782753
PDC10_HUMANPDCD10physical
18782753
SIKE1_HUMANSIKE1physical
18782753
STRP2_HUMANSTRIP2physical
18782753
TCPQ_HUMANCCT8physical
18782753
TCPA_HUMANTCP1physical
18782753
TCPE_HUMANCCT5physical
18782753
FGOP2_HUMANFGFR1OP2physical
18782753
DYL1_HUMANDYNLL1physical
18782753
TRAF3_HUMANTRAF3physical
14572659
NDEL1_HUMANNDEL1physical
25416956
FATE1_HUMANFATE1physical
25416956
KASH5_HUMANCCDC155physical
25416956
FGOP2_HUMANFGFR1OP2physical
28514442
SIKE1_HUMANSIKE1physical
28514442
STRP2_HUMANSTRIP2physical
28514442
STRP1_HUMANSTRIP1physical
28514442
STRN3_HUMANSTRN3physical
28514442
STRN_HUMANSTRNphysical
28514442
STRN4_HUMANSTRN4physical
28514442
RGPD8_HUMANRGPD8physical
28514442
PHOCN_HUMANMOB4physical
28514442
RGPD5_HUMANRGPD5physical
28514442
PDC10_HUMANPDCD10physical
28514442
PP2AA_HUMANPPP2CAphysical
28514442
GGPPS_HUMANGGPS1physical
28514442
2AAB_HUMANPPP2R1Bphysical
28514442
RBP2_HUMANRANBP2physical
28514442
STK26_HUMANSTK26physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of T3JAM_HUMAN

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Related Literatures of Post-Translational Modification
Ubiquitylation
ReferencePubMed
"The proteomic reactor facilitates the analysis of affinity-purifiedproteins by mass spectrometry: application for identifyingubiquitinated proteins in human cells.";
Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M.,Haines D.S., Figeys D.;
J. Proteome Res. 6:298-305(2007).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-267, AND MASSSPECTROMETRY.

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