SYTL5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYTL5_HUMAN
• UniProt AC: Q8TDW5
• Protein Name: Synaptotagmin-like protein 5
• Gene Name: SYTL5
• Organism: Homo sapiens (Human).
• Sequence Length: 730
• Subcellular Localization: Membrane; Peripheral membrane protein.
• Protein Description: May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids..
• Protein Sequence: MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEASRVCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWFFEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDGPKRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQEPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKSHRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEETEESIDALVSSQLSTNTHRLASGLSTTSLNSMMSVYSETGDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGTNPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLMLRSSMGKCRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Acetylation	LKRDEYLKKVEDKRI HHHHHHHHHHCHHHH	54.60	7825359
33	Acetylation	KRDEYLKKVEDKRIR HHHHHHHHHCHHHHH	48.54	7825371
116	Phosphorylation	IAQLRIITGEWFFEE EEEEEEHHCCCHHHH	27.03	-
142	Phosphorylation	GTDVVRQSILRRSPG CHHHHHHHHHHHCCC	17.02	24719451
147	Phosphorylation	RQSILRRSPGAEEVQ HHHHHHHCCCHHHHH	22.66	25849741
168	Phosphorylation	QDAEKSDTSPVAGKK HHHHHCCCCCCCCCC	41.86	25849741
169	Phosphorylation	DAEKSDTSPVAGKKA HHHHCCCCCCCCCCC	23.51	25849741
193	Phosphorylation	FLLSKFRSATRGEII CHHHHHCCCCCCEEE	36.80	24719451
195	Phosphorylation	LSKFRSATRGEIITP HHHHCCCCCCEEEEC	40.22	23312004
201	Phosphorylation	ATRGEIITPKTDTGR CCCCEEEECCCCCCC	25.13	23312004
204	Phosphorylation	GEIITPKTDTGRSYS CEEEECCCCCCCEEE	39.74	-
209	Phosphorylation	PKTDTGRSYSLDLDG CCCCCCCEEEECCCC	22.03	27251275
210	Phosphorylation	KTDTGRSYSLDLDGQ CCCCCCEEEECCCCC	16.34	27251275
211	Phosphorylation	TDTGRSYSLDLDGQH CCCCCEEEECCCCCC	19.36	25849741
221	Phosphorylation	LDGQHFRSLKSPPGS CCCCCEECCCCCCCC	38.92	23312004
224	Phosphorylation	QHFRSLKSPPGSDRG CCEECCCCCCCCCCC	41.44	25954137
228	Phosphorylation	SLKSPPGSDRGSTGS CCCCCCCCCCCCCCC	29.88	25954137
233	Phosphorylation	PGSDRGSTGSSDLND CCCCCCCCCCCCCCC	43.86	25954137
236	Phosphorylation	DRGSTGSSDLNDQEP CCCCCCCCCCCCCCC	47.68	25954137
247	Phosphorylation	DQEPGPRTPKSSRSN CCCCCCCCCCCCCCC	37.90	25849741
257	Phosphorylation	SSRSNGVTPGTQSSP CCCCCCCCCCCCCCC	19.87	30257219
260	Phosphorylation	SNGVTPGTQSSPAPS CCCCCCCCCCCCCCC	26.87	22617229
262	Phosphorylation	GVTPGTQSSPAPSTR CCCCCCCCCCCCCCC	37.82	25849741
263	Phosphorylation	VTPGTQSSPAPSTRT CCCCCCCCCCCCCCC	18.44	25849741
267	Phosphorylation	TQSSPAPSTRTVTSV CCCCCCCCCCCCHHH	32.40	22617229
268	Phosphorylation	QSSPAPSTRTVTSVI CCCCCCCCCCCHHHH	29.33	25849741
270	Phosphorylation	SPAPSTRTVTSVISR CCCCCCCCCHHHHCH	28.37	28348404
272	Phosphorylation	APSTRTVTSVISREY CCCCCCCHHHHCHHH	19.36	25002506
273	Phosphorylation	PSTRTVTSVISREYG CCCCCCHHHHCHHHC	17.08	24719451
276	Phosphorylation	RTVTSVISREYGFEN CCCHHHHCHHHCCCC	19.53	25002506
284	Phosphorylation	REYGFENSMDLAAIE HHHCCCCCCCCHHHC	13.38	28348404
298	Phosphorylation	EGTSQELTKSHRRNT CCCCHHHHHHHHCCC	29.73	-
300	Phosphorylation	TSQELTKSHRRNTSG CCHHHHHHHHCCCCC	19.59	-
305	Phosphorylation	TKSHRRNTSGTPSIA HHHHHCCCCCCCEEE	27.07	28348404
306	Phosphorylation	KSHRRNTSGTPSIAV HHHHCCCCCCCEEEE	44.19	25849741
308	Phosphorylation	HRRNTSGTPSIAVSG HHCCCCCCCEEEEEC	17.40	28348404
314	Phosphorylation	GTPSIAVSGTSLSSD CCCEEEEECCCCCCC	27.60	28348404
316	Phosphorylation	PSIAVSGTSLSSDQS CEEEEECCCCCCCCC	20.98	28348404
317	Phosphorylation	SIAVSGTSLSSDQSR EEEEECCCCCCCCCC	29.76	28348404
319	Phosphorylation	AVSGTSLSSDQSRSE EEECCCCCCCCCCCC	31.47	28348404
320	Phosphorylation	VSGTSLSSDQSRSEL EECCCCCCCCCCCCC	44.99	26471730
323	Phosphorylation	TSLSSDQSRSELDLS CCCCCCCCCCCCCCC	42.64	26471730
332	Phosphorylation	SELDLSESFTEDSED CCCCCCHHCCCCCCC	33.81	-
347	Phosphorylation	TVSIRSKSVPGALDK CEEEEECCCCCCCCH	34.49	22617229
356	Phosphorylation	PGALDKDSLEETEES CCCCCHHHHHHHHHH	43.34	25849741
363	Phosphorylation	SLEETEESIDALVSS HHHHHHHHHHHHHHH	21.38	27966365
393	Phosphorylation	TSLNSMMSVYSETGD CCHHHHHHHEECCCC	14.84	28348404
395	Phosphorylation	LNSMMSVYSETGDYG HHHHHHHEECCCCCC	8.09	27251275
396	Phosphorylation	NSMMSVYSETGDYGN HHHHHHEECCCCCCC	26.90	28348404
449	Phosphorylation	RTDAYVKSYLLPDKS HHHHHHHHHCCCCCC	15.80	28102081
450	Phosphorylation	TDAYVKSYLLPDKSR HHHHHHHHCCCCCCC	13.41	28102081
479	Phosphorylation	EFNETLKYTISHTQL HHHHHHEEEEEECCE	16.65	23312004
480	Phosphorylation	FNETLKYTISHTQLE HHHHHEEEEEECCEE	17.89	23312004
482	Phosphorylation	ETLKYTISHTQLETR HHHEEEEEECCEEEC	16.81	25849741
484	Phosphorylation	LKYTISHTQLETRTL HEEEEEECCEEECEE	28.23	23312004
504	Phosphorylation	HYDRFGRNSFLGEVE EECCCCCCCCEEEEE	37.18	24719451
581	Phosphorylation	KKGKKKESPVISGGI CCCCCCCCCCCCCCH	33.09	24719451
600	Phosphorylation	IKEAKNLTAVKSGGT HHHHHCCEEEECCCC	38.51	23312004
603	Phosphorylation	AKNLTAVKSGGTSDS HHCCEEEECCCCCCC	40.70	24719451
604	Phosphorylation	KNLTAVKSGGTSDSF HCCEEEECCCCCCCC	35.54	23312004
607	Phosphorylation	TAVKSGGTSDSFVKG EEEECCCCCCCCCCC	32.65	23312004
608	Phosphorylation	AVKSGGTSDSFVKGY EEECCCCCCCCCCCE	34.23	23312004
610	Phosphorylation	KSGGTSDSFVKGYLL ECCCCCCCCCCCEEC	31.54	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYTL5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYTL5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYTL5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RB27A_HUMAN	RAB27A	physical	12051743
RAB3A_HUMAN	RAB3A	physical	12051743
RAB6A_HUMAN	RAB6A	physical	12051743

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.