MTU1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTU1_HUMAN
• UniProt AC: O75648
• Protein Name: Mitochondrial tRNA-specific 2-thiouridylase 1
• Gene Name: TRMU
• Organism: Homo sapiens (Human).
• Sequence Length: 421
• Subcellular Localization: Mitochondrion .
• Protein Description: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base..
• Protein Sequence: MQALRHVVCALSGGVDSAVAALLLRRRGYQVTGVFMKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWNDVFSDFLNEYEKGRTPNPDIVCNKHIKFSCFFHYAVDNLGADAIATGHYARTSLEDEEVFEQKHVKKPEGLFRNRFEVRNAVKLLQAADSFKDQTFFLSQVSQDALRRTIFPLGGLTKEFVKKIAAENRLHHVLQKKESMGMCFIGKRNFEHFLLQYLQPRPGHFISIEDNKVLGTHKGWFLYTLGQRANIGGLREPWYVVEKDSVKGDVFVAPRTDHPALYRDLLRTSRVHWIAEEPPAALVRDKMMECHFRFRHQMALVPCVLTLNQDGTVWVTAVQAVRALATGQFAVFYKGDECLGSGKILRLGPSAYTLQKGQRRAGMATESPSDSPEDGPGLSPLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4 (in isoform 4)	Phosphorylation	-	1.88	18669648
4 (in isoform 3)	Phosphorylation	-	1.88	18669648
17	Phosphorylation	ALSGGVDSAVAALLL HHCCCHHHHHHHHHH	23.41	-
52	Ubiquitination	HGVCTADKDCEDAYR CCCCCCCCCHHHHHH	62.91	-
91	Ubiquitination	DFLNEYEKGRTPNPD HHHHHHHCCCCCCCC	53.44	-
94	Phosphorylation	NEYEKGRTPNPDIVC HHHHCCCCCCCCCCC	35.77	-
103	Acetylation	NPDIVCNKHIKFSCF CCCCCCCCCCEEEHH	41.39	25953088
103	Ubiquitination	NPDIVCNKHIKFSCF CCCCCCCCCCEEEHH	41.39	-
103	Malonylation	NPDIVCNKHIKFSCF CCCCCCCCCCEEEHH	41.39	26320211
131	Phosphorylation	ATGHYARTSLEDEEV HCCCCCCCCCCCHHH	29.50	26471730
132	Phosphorylation	TGHYARTSLEDEEVF CCCCCCCCCCCHHHH	24.98	26471730
132 (in isoform 3)	Ubiquitination	-	24.98	21906983
132 (in isoform 4)	Ubiquitination	-	24.98	21906983
142	Ubiquitination	DEEVFEQKHVKKPEG CHHHHHHHCCCCCCC	43.07	-
145	Ubiquitination	VFEQKHVKKPEGLFR HHHHHCCCCCCCCCC	63.43	-
146	Malonylation	FEQKHVKKPEGLFRN HHHHCCCCCCCCCCC	47.41	26320211
146	Ubiquitination	FEQKHVKKPEGLFRN HHHHCCCCCCCCCCC	47.41	-
215	Ubiquitination	RLHHVLQKKESMGMC CHHHHHHHCCCCCEE	55.11	-
286	Ubiquitination	VVEKDSVKGDVFVAP EEECCCCCCEEEEEE	54.03	2190698
286 (in isoform 2)	Ubiquitination	-	54.03	21906983
332	Methylation	KMMECHFRFRHQMAL HHHHHCHHHHHHHHC	12.20	24380761
332	Dimethylation	KMMECHFRFRHQMAL HHHHHCHHHHHHHHC	12.20	-
391	Phosphorylation	LRLGPSAYTLQKGQR EEECCCEEECCCCCC	16.60	-
395	Ubiquitination	PSAYTLQKGQRRAGM CCEEECCCCCCCCCC	61.19	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTU1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTU1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTU1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MTU1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• 613070: Liver failure, infantile, transient (LFIT)
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.