MCEE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCEE_HUMAN
• UniProt AC: Q96PE7
• Protein Name: Methylmalonyl-CoA epimerase, mitochondrial
• Gene Name: MCEE
• Organism: Homo sapiens (Human).
• Sequence Length: 176
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MARVLKAAAANAVGLFSRLQAPIPTVRASSTSQPLDQVTGSVWNLGRLNHVAIAVPDLEKAAAFYKNILGAQVSEAVPLPEHGVSVVFVNLGNTKMELLHPLGRDSPIAGFLQKNKAGGMHHICIEVDNINAAVMDLKKKKIRSLSEEVKIGAHGKPVIFLHPKDCGGVLVELEQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Acetylation	IAVPDLEKAAAFYKN EECCCHHHHHHHHHH	51.10	25953088
114	Acetylation	PIAGFLQKNKAGGMH CCHHHHHHCCCCCCC	63.66	19608861
114	Succinylation	PIAGFLQKNKAGGMH CCHHHHHHCCCCCCC	63.66	-
114	Malonylation	PIAGFLQKNKAGGMH CCHHHHHHCCCCCCC	63.66	26320211
114	Succinylation	PIAGFLQKNKAGGMH CCHHHHHHCCCCCCC	63.66	27452117
150	Acetylation	RSLSEEVKIGAHGKP HHHCCCEEECCCCCE	38.41	25953088
150	Succinylation	RSLSEEVKIGAHGKP HHHCCCEEECCCCCE	38.41	-
150	Malonylation	RSLSEEVKIGAHGKP HHHCCCEEECCCCCE	38.41	26320211
150	Succinylation	RSLSEEVKIGAHGKP HHHCCCEEECCCCCE	38.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCEE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCEE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCEE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
CKLF5_HUMAN	CMTM5	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 251120: Methylmalonyl-CoA epimerase deficiency (MCEED)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-114, AND MASS SPECTROMETRY.
PubMed: 19608861