TEKT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TEKT2_HUMAN
• UniProt AC: Q9UIF3
• Protein Name: Tektin-2
• Gene Name: TEKT2
• Organism: Homo sapiens (Human).
• Sequence Length: 430
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium axoneme . Cytoplasm, cytoskeleton, flagellum axoneme . Cytoplasm, cytoskeleton, microtubule organizing center . Colocalized with CCDC172 at the perinuclear region.
• Protein Description: Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules..
• Protein Sequence: MATLSVKPSRRFQLPDWHTNSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAERFVPEVDTFTRTTNSTLSPLKSCQLELA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MATLSVKPSRRF ---CCCCCCCCCCCC	24.60	24114839
9	Phosphorylation	ATLSVKPSRRFQLPD CCCCCCCCCCCCCCC	30.30	24114839
147	Phosphorylation	EVEVIEATKKALQQK HHHHHHHHHHHHHHH	21.93	-
191	Phosphorylation	EIDRGCLSLNLRSPN EECCCCEEECCCCCC	21.20	25693802
200	Phosphorylation	NLRSPNISLKVDPTR CCCCCCEEEEECCCC	28.86	24719451
237	Phosphorylation	EAEMKAATELREATA HHHHHHHHHHHHHHH	40.17	20068231
310	Phosphorylation	DLRTKLLSLKLSHTR HHHHHHHHHHCCCHH	33.62	24719451
322	Phosphorylation	HTRLEARTYRPNVEL CHHHHCCCCCCCHHH	30.81	29083192
323	Phosphorylation	TRLEARTYRPNVELC HHHHCCCCCCCHHHC	20.65	29083192
353	Acetylation	EATIAALKQKLAQAQ HHHHHHHHHHHHHHH	40.43	25038526
380	Acetylation	LQADIACKANSMLLD HHHHHHHHHHHHEEC	41.39	18585343
396	Acetylation	KCMDTRRKLTVPAER CCCCCCCCCCCCHHH	45.26	12650589
414	Phosphorylation	EVDTFTRTTNSTLSP CCCCCEECCCCCCCC	27.54	30576142
415	Phosphorylation	VDTFTRTTNSTLSPL CCCCEECCCCCCCCH	24.71	30576142
417	Phosphorylation	TFTRTTNSTLSPLKS CCEECCCCCCCCHHH	28.74	30622161
418	Phosphorylation	FTRTTNSTLSPLKSC CEECCCCCCCCHHHC	33.07	30622161
420	Phosphorylation	RTTNSTLSPLKSCQL ECCCCCCCCHHHCCE	28.42	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TEKT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TEKT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TEKT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYFB_HUMAN	FARSB	physical	26186194
ACO11_HUMAN	ACOT11	physical	26186194
PTER_HUMAN	PTER	physical	26186194
CE170_HUMAN	CEP170	physical	26186194
CENPH_HUMAN	CENPH	physical	26186194
C102A_HUMAN	CCDC102A	physical	26186194
MMAB_HUMAN	MMAB	physical	26186194
MAP2_HUMAN	METAP2	physical	26186194
PUR8_HUMAN	ADSL	physical	26186194
PDIP3_HUMAN	POLDIP3	physical	26186194
PLCG1_HUMAN	PLCG1	physical	26186194
HELLS_HUMAN	HELLS	physical	26186194
P20D2_HUMAN	PM20D2	physical	26186194
KLH42_HUMAN	KLHL42	physical	26186194
GNB1L_HUMAN	GNB1L	physical	26186194
CENPH_HUMAN	CENPH	physical	28514442
PTER_HUMAN	PTER	physical	28514442
ACO11_HUMAN	ACOT11	physical	28514442
GNB1L_HUMAN	GNB1L	physical	28514442
MMAB_HUMAN	MMAB	physical	28514442
KLH42_HUMAN	KLHL42	physical	28514442
GFAP_HUMAN	GFAP	physical	28514442
C102A_HUMAN	CCDC102A	physical	28514442
CE170_HUMAN	CEP170	physical	28514442
PLCG1_HUMAN	PLCG1	physical	28514442
PUR8_HUMAN	ADSL	physical	28514442
CENPH_HUMAN	CENPH	physical	27173435
CE170_HUMAN	CEP170	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.