ACO11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACO11_HUMAN
• UniProt AC: Q8WXI4
• Protein Name: Acyl-coenzyme A thioesterase 11
• Gene Name: ACOT11
• Organism: Homo sapiens (Human).
• Sequence Length: 607
• Subcellular Localization: Cytoplasm.
• Protein Description: Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates..
• Protein Sequence: MIQNVGNHLRRGLASVFSNRTSRKSALRAGNDSAMADGEGYRNPTEVQMSQLVLPCHTNQRGELSVGQLLKWIDTTACLSAERHAGCPCVTASMDDIYFEHTISVGQVVNIKAKVNRAFNSSMEVGIQVASEDLCSEKQWNVCKALATFVARREITKVKLKQITPRTEEEKMEHSVAAERRRMRLVYADTIKDLLANCAIQGDLESRDCSRMVPAEKTRVESVELVLPPHANHQGNTFGGQIMAWMENVATIAASRLCRAHPTLKAIEMFHFRGPSQVGDRLVLKAIVNNAFKHSMEVGVCVEAYRQEAETHRRHINSAFMTFVVLDADDQPQLLPWIRPQPGDGERRYREASARKKIRLDRKYIVSCKQTEVPLSVPWDPSNQVYLSYNNVSSLKMLVAKDNWVLSSEISQVRLYTLEDDKFLSFHMEMVVHVDAAQAFLLLSDLRQRPEWDKHYRSVELVQQVDEDDAIYHVTSPALGGHTKPQDFVILASRRKPCDNGDPYVIALRSVTLPTHRETPEYRRGETLCSGFCLWREGDQLTKCCWVRVSLTELVSASGFYSWGLESRSKGRRSDGWNGKLAGGHLSTLKAIPVAKINSRFGYLQDT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	HLRRGLASVFSNRTS HHHHHHHHHHCCCCC	28.83	28857561
25	Phosphorylation	SNRTSRKSALRAGND CCCCCHHHHHHCCCC	31.27	-
45	Phosphorylation	GEGYRNPTEVQMSQL CCCCCCCCCEEEEEE	52.95	46157857
80	Phosphorylation	IDTTACLSAERHAGC HHHHHHHCHHHHCCC	28.15	24719451
131	Phosphorylation	EVGIQVASEDLCSEK CEEEEECCHHHCCHH	32.55	29978859
136	Phosphorylation	VASEDLCSEKQWNVC ECCHHHCCHHHHHHH	55.94	29978859
367	Phosphorylation	LDRKYIVSCKQTEVP CCCEEEEEEECCCCC	13.16	17693683
388	Phosphorylation	PSNQVYLSYNNVSSL CCCCEEEEECCCCCC	14.23	50563199
444	Phosphorylation	AQAFLLLSDLRQRPE HHHHHHHHHHHHCCH	34.27	113136071
496	Malonylation	VILASRRKPCDNGDP EEEECCCCCCCCCCC	49.22	26320211
510	O-linked_Glycosylation	PYVIALRSVTLPTHR CEEEEEEEEECCCCC	21.94	30379171
599	Phosphorylation	IPVAKINSRFGYLQD EEEEEECCCCCCCCC	32.24	30576142
603	Phosphorylation	KINSRFGYLQDT--- EECCCCCCCCCC---	9.85	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACO11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACO11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACO11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACO11_HUMAN	ACOT11	physical	21738568
THUM3_HUMAN	THUMPD3	physical	26186194
THUM3_HUMAN	THUMPD3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction.";
Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.;
Mol. Cell. Proteomics 6:1952-1967(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-367, AND MASSSPECTROMETRY.
PubMed: 17693683