UNC5C_HUMAN - dbPTM
UNC5C_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UNC5C_HUMAN
UniProt AC O95185
Protein Name Netrin receptor UNC5C
Gene Name UNC5C
Organism Homo sapiens (Human).
Sequence Length 931
Subcellular Localization Cell membrane
Single-pass type I membrane protein . Cell junction, synapse, synaptosome .
Protein Description Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand..
Protein Sequence MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTFTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
52O-linked_GlycosylationFFHELPETFPSDPPE
CHHCCCCCCCCCCCC		38.62OGP
55O-linked_GlycosylationELPETFPSDPPEPLP
CCCCCCCCCCCCCCC		59.57OGP
123PhosphorylationGLIVREVSIEISRQQ
CEEEEEEEEEEEHHH		15.11-
127PhosphorylationREVSIEISRQQVEEL
EEEEEEEEHHHHHHH		15.96-
234PhosphorylationKQARLSDTANYTCVA
EECCCCCCCCCEEEE		17.2728152594
236N-linked_GlycosylationARLSDTANYTCVAKN
CCCCCCCCCEEEEEE		34.44UniProtKB CARBOHYD
237PhosphorylationRLSDTANYTCVAKNI
CCCCCCCCEEEEEEE		10.0728152594
238PhosphorylationLSDTANYTCVAKNIV
CCCCCCCEEEEEEEE		10.5828152594
310PhosphorylationSVQKIACTTLCPVDG
CEEEEEEEEECCCCC		17.49-
311PhosphorylationVQKIACTTLCPVDGR
EEEEEEEEECCCCCC		26.67-
361N-linked_GlycosylationGLVLQSKNCTDGLCM
CEEEECCCCCCCCCC		38.89UniProtKB CARBOHYD
429UbiquitinationGFQPVNIKAARQDLL
CCCCCCHHHHHCHHH		30.69-
448 (in isoform 2)Ubiquitination-1.69-
454PhosphorylationAMYRGPVYALHDVSD
HHHCCCEEEEEECCC		13.4325884760
460PhosphorylationVYALHDVSDKIPMTN
EEEEEECCCCCCCCC		38.9627732954
466PhosphorylationVSDKIPMTNSPILDP
CCCCCCCCCCCCCCC		27.4727732954
468PhosphorylationDKIPMTNSPILDPLP
CCCCCCCCCCCCCCC		12.2627732954
481 (in isoform 2)Ubiquitination-5.19-
482PhosphorylationPNLKIKVYNTSGAVT
CCCEEEEEECCCCCC		14.0227732954
484PhosphorylationLKIKVYNTSGAVTPQ
CEEEEEECCCCCCCC		15.7325884760
485PhosphorylationKIKVYNTSGAVTPQD
EEEEEECCCCCCCCC		22.5527732954
489PhosphorylationYNTSGAVTPQDDLSE
EECCCCCCCCCCHHH		18.0727732954
495PhosphorylationVTPQDDLSEFTSKLS
CCCCCCHHHHHHHCC		37.3427732954
497 (in isoform 2)Ubiquitination-9.32-
502PhosphorylationSEFTSKLSPQMTQSL
HHHHHHCCHHHHHHH		19.4727732954
506PhosphorylationSKLSPQMTQSLLENE
HHCCHHHHHHHHHHH		15.1227732954
516PhosphorylationLLENEALSLKNQSLA
HHHHHHHHHHHHHHH		44.3327732954
519 (in isoform 2)Ubiquitination-41.80-
521PhosphorylationALSLKNQSLARQTDP
HHHHHHHHHHHCCCC		33.13-
537 (in isoform 2)Ubiquitination-37.71-
568PhosphorylationQGRVYEMYVTVHRKE
CCCEEEEEEEEECCC		4.88-
570O-linked_GlycosylationRVYEMYVTVHRKETM
CEEEEEEEEECCCCC		7.9731492838
674PhosphorylationYALVGHSTTKAAAKR
HHHCCCHHHHHHHHH		27.00-
693PhosphorylationIFGPLCCSSLEYSIR
HHCCCCCCCCCEEEE		36.6427732954
694PhosphorylationFGPLCCSSLEYSIRV
HCCCCCCCCCEEEEE		16.0027732954
697PhosphorylationLCCSSLEYSIRVYCL
CCCCCCCEEEEEEEE		18.0727732954
698PhosphorylationCCSSLEYSIRVYCLD
CCCCCCEEEEEEEEC		8.4424719451
832PhosphorylationPLLDPANTITTVTGP
CCCCCCCCEEEECCC		23.08-
843PhosphorylationVTGPSAFSIPLPIRQ
ECCCCCCCCCCCHHH		24.02-
854PhosphorylationPIRQKLCSSLDAPQT
CHHHHHHHCCCCCCC		44.3521712546
861PhosphorylationSSLDAPQTRGHDWRM
HCCCCCCCCCCHHHH		37.2421712546
878PhosphorylationHKLNLDRYLNYFATK
HHCCHHHHHHHHCCC		10.0425884760
881PhosphorylationNLDRYLNYFATKSSP
CHHHHHHHHCCCCCC		7.6225884760
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UNC5C_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UNC5C_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UNC5C_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of UNC5C_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UNC5C_HUMAN

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Related Literatures of Post-Translational Modification

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