CSKI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSKI1_HUMAN
• UniProt AC: Q8WXD9
• Protein Name: Caskin-1
• Gene Name: CASKIN1
• Organism: Homo sapiens (Human).
• Sequence Length: 1431
• Subcellular Localization: Cytoplasm.
• Protein Description: May link the scaffolding protein CASK to downstream intracellular effectors..
• Protein Sequence: MGKEQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYCNNYDLTSLNVKAGDIITVLEQHPDGRWKGCIHDNRTGNDRVGYFPSSLGEAIVKRAGSRAGTEPSLPQGSSSSGPSAPPEEIWVLRKPFAGGDRSGSISGMAGGRGSGGHALHAGSEGVKLLATVLSQKSVSESGPGDSPAKPPEGSAGVARSQPPVAHAGQVYGEQPPKKLEPASEGKSSEAVSQWLTAFQLQLYAPNFISAGYDLPTISRMTPEDLTAIGVTKPGHRKKIAAEISGLSIPDWLPEHKPANLAVWLSMIGLAQYYKVLVDNGYENIDFITDITWEDLQEIGITKLGHQKKLMLAVRKLAELQKAEYAKYEGGPLRRKAPQSLEVMAIESPPPPEPTPADCQSPKMTTFQDSELSDELQAAMTGPAEVGPTTEKPSSHLPPTPRATTRQDSSLGGRARHMSSSQELLGDGPPGPSSPMSRSQEYLLDEGPAPGTPPREARPGRHGHSIKRASVPPVPGKPRQVLPPGTSHFTPPQTPTKTRPGSPQALGGPHGPAPATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAYVLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPAGADKNVNRSQSFAVRPRKKGPPPPPPKRSSSALASANLADEPVPDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPEGHPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARRGPGESADPGPFVEDGTGRQRPRGPSKGEAGVEGPPLAKVEASATLKRRIRAKQNQQENVKFILTESDTVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLPGPGSPEVKRAHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPALHVPAKPPRAAAAAAAAAAAPPAPPEGASPGDSARQKLEETSACLAAALQAVEEKIRQEDAQGPRDSAAEKSTGSILDDIGSMFDDLADQLDAMLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	GKAKLLGSTKKINVN CCCEECCCCCEEECC	36.70	24719451
37	Phosphorylation	KAKLLGSTKKINVNF CCEECCCCCEEECCC	34.26	23312004
149	Ubiquitination	CMVDNSGKTPLDLAC CEECCCCCCCHHHHH	46.95	-
233	Ubiquitination	HEAALCGKTEVVRLL HHHHHCCCHHHHHHH	40.28	30230243
234	Phosphorylation	EAALCGKTEVVRLLL HHHHCCCHHHHHHHH	21.21	-
253	Phosphorylation	NAHVRNTYSQTALDI CHHHCCCCCCHHHHH	11.43	-
292	Phosphorylation	QVRATKDYCNNYDLT HHHHCCHHHCCCCCC	9.91	27196784
296	Phosphorylation	TKDYCNNYDLTSLNV CCHHHCCCCCCCCEE	9.80	22817900
300	Phosphorylation	CNNYDLTSLNVKAGD HCCCCCCCCEECCCC	25.83	27067055
336	Phosphorylation	TGNDRVGYFPSSLGE CCCCCEECCCHHHHH	14.95	17192257
347	Ubiquitination	SLGEAIVKRAGSRAG HHHHHHHHHHHCCCC	30.34	30230243
358	Phosphorylation	SRAGTEPSLPQGSSS CCCCCCCCCCCCCCC	46.58	-
388	Phosphorylation	PFAGGDRSGSISGMA CCCCCCCCCCCCCCC	41.45	28348404
390	Phosphorylation	AGGDRSGSISGMAGG CCCCCCCCCCCCCCC	18.15	24719451
398	Methylation	ISGMAGGRGSGGHAL CCCCCCCCCCCCCCC	34.88	24129315
423	Phosphorylation	ATVLSQKSVSESGPG HHHHHCCCCCCCCCC	24.20	24076635
425	Phosphorylation	VLSQKSVSESGPGDS HHHCCCCCCCCCCCC	32.89	25307156
432	Phosphorylation	SESGPGDSPAKPPEG CCCCCCCCCCCCCCC	32.45	25307156
435	Ubiquitination	GPGDSPAKPPEGSAG CCCCCCCCCCCCCCC	65.57	30230243
518	Ubiquitination	LTAIGVTKPGHRKKI HHEEECCCCCCHHHH	46.74	-
601	"N6,N6-dimethyllysine"	KLMLAVRKLAELQKA HHHHHHHHHHHHHHH	45.51	-
601	Methylation	KLMLAVRKLAELQKA HHHHHHHHHHHHHHH	45.51	-
607	"N6,N6-dimethyllysine"	RKLAELQKAEYAKYE HHHHHHHHHHHHHCC	56.67	-
607	Methylation	RKLAELQKAEYAKYE HHHHHHHHHHHHHCC	56.67	-
610	Phosphorylation	AELQKAEYAKYEGGP HHHHHHHHHHCCCCC	17.16	22817900
612	Ubiquitination	LQKAEYAKYEGGPLR HHHHHHHHCCCCCCC	42.82	30230243
612	"N6,N6-dimethyllysine"	LQKAEYAKYEGGPLR HHHHHHHHCCCCCCC	42.82	-
612	Methylation	LQKAEYAKYEGGPLR HHHHHHHHCCCCCCC	42.82	-
613	Phosphorylation	QKAEYAKYEGGPLRR HHHHHHHCCCCCCCC	16.19	28796482
633	Phosphorylation	LEVMAIESPPPPEPT EEEEEECCCCCCCCC	36.27	-
640	Phosphorylation	SPPPPEPTPADCQSP CCCCCCCCCCCCCCC	29.46	24076635
646	Phosphorylation	PTPADCQSPKMTTFQ CCCCCCCCCCCCCCC	32.59	24076635
704	Phosphorylation	GGRARHMSSSQELLG CCCHHCCCCCHHHHC	22.25	20363803
705	Phosphorylation	GRARHMSSSQELLGD CCHHCCCCCHHHHCC	28.59	27732954
706	Phosphorylation	RARHMSSSQELLGDG CHHCCCCCHHHHCCC	21.99	20363803
718	Phosphorylation	GDGPPGPSSPMSRSQ CCCCCCCCCCCCHHH	53.65	20363803
719	Phosphorylation	DGPPGPSSPMSRSQE CCCCCCCCCCCHHHH	27.96	20363803
722	Phosphorylation	PGPSSPMSRSQEYLL CCCCCCCCHHHHHHC	31.97	27732954
724	Phosphorylation	PSSPMSRSQEYLLDE CCCCCCHHHHHHCCC	21.76	20363803
727	Phosphorylation	PMSRSQEYLLDEGPA CCCHHHHHHCCCCCC	12.62	27732954
737	Phosphorylation	DEGPAPGTPPREARP CCCCCCCCCCCCCCC	29.12	20363803
755	Phosphorylation	GHSIKRASVPPVPGK CCCCCCCCCCCCCCC	38.91	24719451
771	Phosphorylation	RQVLPPGTSHFTPPQ CCCCCCCCCCCCCCC	25.46	24076635
772	Phosphorylation	QVLPPGTSHFTPPQT CCCCCCCCCCCCCCC	23.63	24076635
775	Phosphorylation	PPGTSHFTPPQTPTK CCCCCCCCCCCCCCC	28.74	24076635
779	Phosphorylation	SHFTPPQTPTKTRPG CCCCCCCCCCCCCCC	38.40	24719451
783	Phosphorylation	PPQTPTKTRPGSPQA CCCCCCCCCCCCCCH	44.57	28152594
787	Phosphorylation	PTKTRPGSPQALGGP CCCCCCCCCCHHCCC	19.27	22617229
807	Phosphorylation	ATAKVKPTPQLLPPT CCCCCCCCCCCCCCC	20.25	23312004
814	Phosphorylation	TPQLLPPTERPMSPR CCCCCCCCCCCCCCC	42.56	28348404
819	Phosphorylation	PPTERPMSPRSLPQS CCCCCCCCCCCCCCC	21.61	23312004
822	Phosphorylation	ERPMSPRSLPQSPTH CCCCCCCCCCCCCCC	48.03	20363803
826	Phosphorylation	SPRSLPQSPTHRGFA CCCCCCCCCCCCCEE	29.81	20363803
828	Phosphorylation	RSLPQSPTHRGFAYV CCCCCCCCCCCEEEE	29.47	30266825
882	Phosphorylation	RPKKRAHSLNRYAAS CCCCCHHHHCCCCCC	26.76	28102081
886	Phosphorylation	RAHSLNRYAASDSEP CHHHHCCCCCCCCCC	12.87	20363803
889	Phosphorylation	SLNRYAASDSEPERD HHCCCCCCCCCCCHH	33.23	27732954
891	Phosphorylation	NRYAASDSEPERDEL CCCCCCCCCCCHHHC	53.18	20363803
907	Phosphorylation	VPAAAGPYATVQRRV EECCCCCCHHHHCCC	17.62	27642862
919	Phosphorylation	RRVGRSHSVRAPAGA CCCCCCCCCCCCCCC	17.97	24719451
933	Phosphorylation	ADKNVNRSQSFAVRP CCCCCCHHHCCCCCC	25.60	28348404
935	Phosphorylation	KNVNRSQSFAVRPRK CCCCHHHCCCCCCCC	19.20	23312004
953	Phosphorylation	PPPPPKRSSSALASA CCCCCCCCHHHHHHC	34.47	27732954
954	Phosphorylation	PPPPKRSSSALASAN CCCCCCCHHHHHHCC	24.54	27732954
955	Phosphorylation	PPPKRSSSALASANL CCCCCCHHHHHHCCC	28.66	27732954
959	Phosphorylation	RSSSALASANLADEP CCHHHHHHCCCCCCC	20.66	27732954
987	Phosphorylation	RAQCRRASDLAGSVD HHHHHCHHHHCCCCC	31.20	25849741
995	Phosphorylation	DLAGSVDTGSAGSVK HHCCCCCCCCCCCHH	30.77	27251275
997	Phosphorylation	AGSVDTGSAGSVKSI CCCCCCCCCCCHHHH	31.39	24719451
1000	Phosphorylation	VDTGSAGSVKSIAAM CCCCCCCCHHHHHHH	26.53	27251275
1029	Phosphorylation	RPPEGHPTPRPASPE CCCCCCCCCCCCCCC	26.67	-
1034	Phosphorylation	HPTPRPASPEPGRVA CCCCCCCCCCCCCCC	32.26	20363803
1046	Phosphorylation	RVATVLASVKHKEAI CCCEEEEECCCHHHC	27.77	-
1065	Phosphorylation	EVVNRRRTLSGPVTG CCCCCCCCCCCCCHH	24.38	27273156
1067	Phosphorylation	VNRRRTLSGPVTGLL CCCCCCCCCCCHHHH	40.20	20363803
1071	Phosphorylation	RTLSGPVTGLLATAR CCCCCCCHHHHHHHC	25.83	27251275
1076	Phosphorylation	PVTGLLATARRGPGE CCHHHHHHHCCCCCC	22.21	-
1121	Phosphorylation	PLAKVEASATLKRRI CCCCCHHHHHHHHHH	14.31	23312004
1123	Phosphorylation	AKVEASATLKRRIRA CCCHHHHHHHHHHHH	30.25	23312004
1143	O-linked_Glycosylation	ENVKFILTESDTVKR HCCEEEEECCHHHCC	28.73	28411811
1145	O-linked_Glycosylation	VKFILTESDTVKRRP CEEEEECCHHHCCCC	33.09	28411811
1227	Phosphorylation	KPAKPPVSPKPVLTQ CCCCCCCCCCCCCCC	32.74	24719451
1242	Phosphorylation	PVPKLQGSPTPTSKK CCCCCCCCCCCCCCC	16.79	25849741
1244	Phosphorylation	PKLQGSPTPTSKKVP CCCCCCCCCCCCCCC	40.68	27732954
1257	Phosphorylation	VPLPGPGSPEVKRAH CCCCCCCCHHHHHHC	22.48	30266825
1266	Phosphorylation	EVKRAHGTPPPVSPK HHHHHCCCCCCCCCC	23.82	25332170
1292	Phosphorylation	KAVAGLPSGSAGPSP EEEECCCCCCCCCCC	50.88	27732954
1294	Phosphorylation	VAGLPSGSAGPSPAP EECCCCCCCCCCCCC	34.10	27732954
1298	Phosphorylation	PSGSAGPSPAPSPAR CCCCCCCCCCCCCCC	32.54	27732954
1302	Phosphorylation	AGPSPAPSPARQPPA CCCCCCCCCCCCCCH	33.04	27732954
1364	Phosphorylation	PAPPEGASPGDSARQ CCCCCCCCCCHHHHH	40.03	24076635
1376	Phosphorylation	ARQKLEETSACLAAA HHHHHHHHHHHHHHH	16.55	26074081
1377	Phosphorylation	RQKLEETSACLAAAL HHHHHHHHHHHHHHH	21.92	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSKI1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSKI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSKI1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CSKI1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1257, AND MASSSPECTROMETRY.
PubMed: 19413330

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-336, AND MASSSPECTROMETRY.
PubMed: 18691976