dbPTM

CD24_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CD24_HUMAN
UniProt AC	P25063
Protein Name	Signal transducer CD24
Gene Name	CD24
Organism	Homo sapiens (Human).
Sequence Length	80
Subcellular Localization	Cell membrane Lipid-anchor, GPI-anchor.
Protein Description	May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. [PubMed: 11313396 In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity]
Protein Sequence	MGRAMVARLGLGLLLLALLLPTQIYSSETTTGTSSNSSQSTSNSGLAPNPTNATTKAAGGALQSTASLFVVSLSLLHLYS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	N-linked_Glycosylation	TTTGTSSNSSQSTSN CCCCCCCCCCCCCCC	45.51	UniProtKB CARBOHYD
52	N-linked_Glycosylation	GLAPNPTNATTKAAG CCCCCCCCCCCHHHH	36.22	UniProtKB CARBOHYD
59	GPI-anchor	NATTKAAGGALQSTA CCCCHHHHHHHHHHH	27.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CD24_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CD24_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CD24_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FGR_HUMAN	FGR	physical	8753773
LYN_HUMAN	LYN	physical	8753773
LYAM3_HUMAN	SELP	physical	9129046
NPM_HUMAN	NPM1	physical	25600590

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CD24_HUMAN

Related Literatures of Post-Translational Modification