| UniProt ID | MC4R_HUMAN | |
|---|---|---|
| UniProt AC | P32245 | |
| Protein Name | Melanocortin receptor 4 | |
| Gene Name | MC4R | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 332 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . |
|
| Protein Description | Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).. | |
| Protein Sequence | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | N-linked_Glycosylation | -----MVNSTHRGMH -----CCCCCCCCCC | 39.63 | UniProtKB CARBOHYD | |
| 17 | N-linked_Glycosylation | HTSLHLWNRSSYRLH CCCEEECCCCHHCCC | 40.07 | UniProtKB CARBOHYD | |
| 26 | N-linked_Glycosylation | SSYRLHSNASESLGK CHHCCCCCCCHHCCC | 36.42 | UniProtKB CARBOHYD | |
| 35 | Phosphorylation | SESLGKGYSDGGCYE CHHCCCCCCCCCHHH | 13.69 | - | |
| 36 | Phosphorylation | ESLGKGYSDGGCYEQ HHCCCCCCCCCHHHH | 38.15 | - | |
| 41 | Phosphorylation | GYSDGGCYEQLFVSP CCCCCCHHHHHCCCH | 15.24 | - | |
| 47 | Phosphorylation | CYEQLFVSPEVFVTL HHHHHCCCHHHHHHH | 14.17 | - | |
| 148 | Phosphorylation | LSIAVDRYFTIFYAL HHHHHHHHHHHHHHH | 10.70 | - | |
| 157 | Phosphorylation | TIFYALQYHNIMTVK HHHHHHHHCCCCCCC | 9.55 | - | |
| 232 | Phosphorylation | RIAVLPGTGAIRQGA EEEECCCCCHHHCCC | 22.85 | 21964256 | |
| 312 | Phosphorylation | RSQELRKTFKEIICC HCHHHHHHHHHHHHC | 33.24 | 12639913 | |
| 318 | S-palmitoylation | KTFKEIICCYPLGGL HHHHHHHHCCCCCHH | 1.92 | - | |
| 329 | Phosphorylation | LGGLCDLSSRY---- CCHHHCCCCCC---- | 10.26 | 12639913 | |
| 330 | Phosphorylation | GGLCDLSSRY----- CHHHCCCCCC----- | 42.78 | 12639913 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 312 | T | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
| 312 | T | Phosphorylation | Kinase | PKA_GROUP | - | PhosphoELM |
| 312 | T | Phosphorylation | Kinase | GRK-SUBFAMILY | - | GPS |
| 312 | T | Phosphorylation | Kinase | GRK_GROUP | - | PhosphoELM |
| 312 | T | Phosphorylation | Kinase | PKA-FAMILY | - | GPS |
| 329 | S | Phosphorylation | Kinase | GRK2 | P21146 | PSP |
| 329 | S | Phosphorylation | Kinase | ARBK1 | P25098 | PhosphoELM |
| 329 | S | Phosphorylation | Kinase | GRK-SUBFAMILY | - | GPS |
| 329 | S | Phosphorylation | Kinase | PKA-FAMILY | - | GPS |
| 329 | S | Phosphorylation | Kinase | GRK_GROUP | - | PhosphoELM |
| 329 | S | Phosphorylation | Kinase | PKA_GROUP | - | PhosphoELM |
| 330 | S | Phosphorylation | Kinase | PKA_GROUP | - | PhosphoELM |
| 330 | S | Phosphorylation | Kinase | GRK_GROUP | - | PhosphoELM |
| 330 | S | Phosphorylation | Kinase | PKA-FAMILY | - | GPS |
| 330 | S | Phosphorylation | Kinase | GRK-SUBFAMILY | - | GPS |
| 330 | S | Phosphorylation | Kinase | ARBK1 | P25098 | PhosphoELM |
| 330 | S | Phosphorylation | Kinase | GRK2 | P21146 | PSP |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MC4R_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MC4R_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MC4R_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 601665 | Obesity (OBESITY) | |||||
| Kegg Drug | ||||||
| D00146 | Corticotropin (USP/INN); ACTH (TN); Acthar (TN) | |||||
| D00284 | Cosyntropin (USAN); Tetracosactide (INN); Cortrosyn (TN) | |||||
| D02105 | Tetracosactide acetate (JAN); Cortrosyn (TN) | |||||
| D03593 | Corticotropin zinc hydroxide (USP); Corticotropin-Zinc (TN) | |||||
| D05827 | Seractide acetate (USAN); Seractide acetate hydrate; Acthar gel-syntehtic (TN) | |||||
| D06544 | Corticotropin, repository (USP); Cortigel (TN) | |||||
| D06569 | Bremelanotide (USAN/INN); PT-141 | |||||
| D07417 | Alsactide (INN) | |||||
| D09801 | Giractide acetate (JAN) | |||||
| D09937 | Giractide (INN) | |||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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