DDX60_HUMAN - dbPTM
DDX60_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DDX60_HUMAN
UniProt AC Q8IY21
Protein Name Probable ATP-dependent RNA helicase DDX60
Gene Name DDX60
Organism Homo sapiens (Human).
Sequence Length 1712
Subcellular Localization Cytoplasm .
Protein Description Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV)..
Protein Sequence MERNVLTTFSQEMSQLILNEMPKAEYSSLFNDFVESEFFLIDGDSLLITCICEISFKPGQNLHFFYLVERYLVDLISKGGQFTIVFFKDAEYAYFNFPELLSLRTALILHLQKNTTIDVRTTFSRCLSKEWGSFLEESYPYFLIVADEGLNDLQTQLFNFLIIHSWARKVNVVLSSGQESDVLCLYAYLLPSMYRHQIFSWKNKQNIKDAYTTLLNQLERFKLSALAPLFGSLKWNNITEEAHKTVSLLTQVWPEGSDIRRVFCVTSCSLSLRMYHRFLGNREPSSGQETEIQQVNSNCLTLQEMEDLCKLHCLTVVFLLHLPLSQRACARVITSHWAEDMKPLLQMKKWCEYFILRNIHTFEFWNLNLIHLSDLNDELLLKNIAFYYENENVKGLHLNLGDTIMKDYEYLWNTVSKLVRDFEVGQPFPLRTTKVCFLEKKPSPIKDSSNEMVPNLGFIPTSSFVVDKFAGDILKDLPFLKSDDPIVTSLVKQKEFDELVHWHSHKPLSDDYDRSRCQFDEKSRDPRVLRSVQKYHVFQRFYGNSLETVSSKIIVTQTIKSKKDFSGPKSKKAHETKAEIIARENKKRLFAREEQKEEQKWNALSFSIEEQLKENLHSGIKSLEDFLKSCKSSCVKLQVEMVGLTACLKAWKEHCRSEEGKTTKDLSIAVQVMKRIHSLMEKYSELLQEDDRQLIARCLKYLGFDELASSLHPAQDAENDVKVKKRNKYSVGIGPARFQLQYMGHYLIRDERKDPDPRVQDFIPDTWQRELLDVVDKNESAVIVAPTSSGKTYASYYCMEKVLKESDDGVVVYVAPTKALVNQVAATVQNRFTKNLPSGEVLCGVFTREYRHDALNCQVLITVPACFEILLLAPHRQNWVKKIRYVIFDEVHCLGGEIGAEIWEHLLVMIRCPFLALSATISNPEHLTEWLQSVKWYWKQEDKIIENNTASKRHVGRQAGFPKDYLQVKQSYKVRLVLYGERYNDLEKHVCSIKHGDIHFDHFHPCAALTTDHIERYGFPPDLTLSPRESIQLYDAMFQIWKSWPRAQELCPENFIHFNNKLVIKKMDARKYEESLKAELTSWIKNGNVEQARMVLQNLSPEADLSPENMITMFPLLVEKLRKMEKLPALFFLFKLGAVENAAESVSTFLKKKQETKRPPKADKEAHVMANKLRKVKKSIEKQKIIDEKSQKKTRNVDQSLIHEAEHDNLVKCLEKNLEIPQDCTYADQKAVDTETLQKVFGRVKFERKGEELKALAERGIGYHHSAMSFKEKQLVEILFRKGYLRVVTATGTLALGVNMPCKSVVFAQNSVYLDALNYRQMSGRAGRRGQDLMGDVYFFDIPFPKIGKLIKSNVPELRGHFPLSITLVLRLMLLASKGDDPEDAKAKVLSVLKHSLLSFKQPRVMDMLKLYFLFSLQFLVKEGYLDQEGNPMGFAGLVSHLHYHEPSNLVFVSFLVNGLFHDLCQPTRKGSKHFSQDVMEKLVLVLAHLFGRRYFPPKFQDAHFEFYQSKVFLDDLPEDFSDALDEYNMKIMEDFTTFLRIVSKLADMNQEYQLPLSKIKFTGKECEDSQLVSHLMSCKEGRVAISPFVCLSGNFDDDLLRLETPNHVTLGTIGVNRSQAPVLLSQKFDNRGRKMSLNAYALDFYKHGSLIGLVQDNRMNEGDAYYLLKDFALTIKSISVSLRELCENEDDNVVLAFEQLSTTFWEKLNKV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
55PhosphorylationITCICEISFKPGQNL
EEEEEEEEECCCCCE		12.6224719451
175PhosphorylationRKVNVVLSSGQESDV
HHCEEEECCCCHHHH		22.3223401153
176PhosphorylationKVNVVLSSGQESDVL
HCEEEECCCCHHHHH		40.0923401153
180PhosphorylationVLSSGQESDVLCLYA
EECCCCHHHHHHHHH		25.7323401153
186PhosphorylationESDVLCLYAYLLPSM
HHHHHHHHHHHHHHH		7.6923401153
188PhosphorylationDVLCLYAYLLPSMYR
HHHHHHHHHHHHHHH		8.6723401153
234UbiquitinationAPLFGSLKWNNITEE
HHHHCCCCCCCCCHH		49.96-
269PhosphorylationVFCVTSCSLSLRMYH
EEEHHHCCHHHHHHH		22.2917081983
271PhosphorylationCVTSCSLSLRMYHRF
EHHHCCHHHHHHHHH		9.5317081983
434UbiquitinationPFPLRTTKVCFLEKK
CCCCCCCEEEEEECC		36.07-
440AcetylationTKVCFLEKKPSPIKD
CEEEEEECCCCCCCC		72.6123749302
475UbiquitinationKFAGDILKDLPFLKS
HHCHHHHHCCCCCCC		58.51-
481UbiquitinationLKDLPFLKSDDPIVT
HHCCCCCCCCCHHHH		52.82-
488PhosphorylationKSDDPIVTSLVKQKE
CCCCHHHHHHHCHHH		19.6423403867
489PhosphorylationSDDPIVTSLVKQKEF
CCCHHHHHHHCHHHH		21.9223403867
492UbiquitinationPIVTSLVKQKEFDEL
HHHHHHHCHHHHHHH		62.03-
506UbiquitinationLVHWHSHKPLSDDYD
HCCCCCCCCCCCCCC		51.15-
531PhosphorylationRDPRVLRSVQKYHVF
CCHHHHHHHHHHHHH		25.4124719451
534UbiquitinationRVLRSVQKYHVFQRF
HHHHHHHHHHHHHHH		34.86-
535PhosphorylationVLRSVQKYHVFQRFY
HHHHHHHHHHHHHHH		6.02-
545PhosphorylationFQRFYGNSLETVSSK
HHHHHCCCHHHCCEE		24.1828348404
556PhosphorylationVSSKIIVTQTIKSKK
CCEEEEEEEEECCCC		15.02-
560AcetylationIIVTQTIKSKKDFSG
EEEEEEECCCCCCCC		60.6627452117
561PhosphorylationIVTQTIKSKKDFSGP
EEEEEECCCCCCCCC		40.88-
563AcetylationTQTIKSKKDFSGPKS
EEEECCCCCCCCCCC		71.7130588091
569AcetylationKKDFSGPKSKKAHET
CCCCCCCCCCCCHHH		77.6924846279
571AcetylationDFSGPKSKKAHETKA
CCCCCCCCCCHHHHH		61.1724846289
577UbiquitinationSKKAHETKAEIIARE
CCCCHHHHHHHHHHH		40.83-
621UbiquitinationENLHSGIKSLEDFLK
HHHHHHHHCHHHHHH		53.14-
628UbiquitinationKSLEDFLKSCKSSCV
HCHHHHHHHCHHHCC		54.52-
700UbiquitinationQLIARCLKYLGFDEL
HHHHHHHHHHCHHHH		41.89-
722UbiquitinationQDAENDVKVKKRNKY
CCCCCCCEECCCCCC		51.72-
724UbiquitinationAENDVKVKKRNKYSV
CCCCCEECCCCCCCC		40.05-
729PhosphorylationKVKKRNKYSVGIGPA
EECCCCCCCCCCCCC		16.49-
777UbiquitinationELLDVVDKNESAVIV
HHHHHCCCCCCEEEE		51.51-
791UbiquitinationVAPTSSGKTYASYYC
EEECCCCCCHHHHHH		40.07-
792PhosphorylationAPTSSGKTYASYYCM
EECCCCCCHHHHHHH		28.0423401153
793PhosphorylationPTSSGKTYASYYCME
ECCCCCCHHHHHHHH		9.3123401153
795PhosphorylationSSGKTYASYYCMEKV
CCCCCHHHHHHHHHH		13.2523401153
796PhosphorylationSGKTYASYYCMEKVL
CCCCHHHHHHHHHHH		7.7823401153
797PhosphorylationGKTYASYYCMEKVLK
CCCHHHHHHHHHHHH		5.2623401153
804UbiquitinationYCMEKVLKESDDGVV
HHHHHHHHHCCCCEE		59.15-
834UbiquitinationTVQNRFTKNLPSGEV
HHHHHHHCCCCCCCE		54.50-
847PhosphorylationEVLCGVFTREYRHDA
CEEEEEEECCCCCCC		21.8624719451
850PhosphorylationCGVFTREYRHDALNC
EEEEECCCCCCCCCC		15.2324719451
949PhosphorylationDKIIENNTASKRHVG
CCCCCCCCCCCCCCC		43.84-
952UbiquitinationIENNTASKRHVGRQA
CCCCCCCCCCCCCCC		44.02-
969UbiquitinationPKDYLQVKQSYKVRL
CHHHHHHHHHEEEEE		22.14-
988UbiquitinationERYNDLEKHVCSIKH
CCCHHHHHHCHHCCC		48.94-
1017PhosphorylationTTDHIERYGFPPDLT
CCHHHHHHCCCCCCC		15.4429457462
1024PhosphorylationYGFPPDLTLSPRESI
HCCCCCCCCCHHHHH		32.3529457462
1026PhosphorylationFPPDLTLSPRESIQL
CCCCCCCCHHHHHHH		19.37-
1043PhosphorylationAMFQIWKSWPRAQEL
HHHHHHHHCHHHHHH		27.5824719451
1061UbiquitinationNFIHFNNKLVIKKMD
CEEEECCEEEEEECC		45.28-
1065UbiquitinationFNNKLVIKKMDARKY
ECCEEEEEECCHHHH		34.27-
1085UbiquitinationAELTSWIKNGNVEQA
HHHHHHHHCCCHHHH		53.17-
1100PhosphorylationRMVLQNLSPEADLSP
HHHHHHCCCCCCCCH		28.39-
1106PhosphorylationLSPEADLSPENMITM
CCCCCCCCHHHHHHH		30.62-
1112PhosphorylationLSPENMITMFPLLVE
CCHHHHHHHHHHHHH		11.29-
1152UbiquitinationSVSTFLKKKQETKRP
HHHHHHHHHHCCCCC		62.93-
1172UbiquitinationEAHVMANKLRKVKKS
HHHHHHHHHHHHHHH		39.88-
1200PhosphorylationKTRNVDQSLIHEAEH
HCCCCCHHHHHHHHH		25.4828555341
1212UbiquitinationAEHDNLVKCLEKNLE
HHHHHHHHHHHHCCC		35.95-
1216UbiquitinationNLVKCLEKNLEIPQD
HHHHHHHHCCCCCCC		54.61-
1230UbiquitinationDCTYADQKAVDTETL
CCCHHCCCCCCHHHH		51.42-
1239UbiquitinationVDTETLQKVFGRVKF
CCHHHHHHHHCCCCC		42.52-
1245AcetylationQKVFGRVKFERKGEE
HHHHCCCCCCCCHHH		39.907851281
1254UbiquitinationERKGEELKALAERGI
CCCHHHHHHHHHCCC		44.63-
1266PhosphorylationRGIGYHHSAMSFKEK
CCCCCCCCCCCCCHH		16.6219651622
1284PhosphorylationEILFRKGYLRVVTAT
HHHHHCCCEEEEEEC		8.3829083192
1289PhosphorylationKGYLRVVTATGTLAL
CCCEEEEEECCEEEE		18.6929083192
1291PhosphorylationYLRVVTATGTLALGV
CEEEEEECCEEEECC		22.7229083192
1293PhosphorylationRVVTATGTLALGVNM
EEEEECCEEEECCCC		12.4229083192
1352UbiquitinationPKIGKLIKSNVPELR
HHHHHHHHCCCHHHC		46.55-
1365PhosphorylationLRGHFPLSITLVLRL
HCCCCCHHHHHHHHH		17.4824719451
1367PhosphorylationGHFPLSITLVLRLML
CCCCHHHHHHHHHHH		13.8724719451
1377PhosphorylationLRLMLLASKGDDPED
HHHHHHHHCCCCHHH		36.82-
1399PhosphorylationVLKHSLLSFKQPRVM
HHHHHHHCCCCCCHH		35.3724719451
1416PhosphorylationLKLYFLFSLQFLVKE
HHHHHHHHHHHHHHC		24.3318452278
1559UbiquitinationEYQLPLSKIKFTGKE
CCCCCHHHCEECCCC		58.56-
1628UbiquitinationAPVLLSQKFDNRGRK
CCEEEEECCCCCCCC		51.84-
1637PhosphorylationDNRGRKMSLNAYALD
CCCCCCCCEEEHHHH		22.8523090842
1646PhosphorylationNAYALDFYKHGSLIG
EEHHHHHHHHCCEEE		11.1819651622
1680PhosphorylationALTIKSISVSLRELC
HHHHHHHHHHHHHHH		16.8524719451
1682PhosphorylationTIKSISVSLRELCEN
HHHHHHHHHHHHHHC		18.2124719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DDX60_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DDX60_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DDX60_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DDX60_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DDX60_HUMAN

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Related Literatures of Post-Translational Modification

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