C2D2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: C2D2B_HUMAN
• UniProt AC: Q6DHV5
• Protein Name: Protein CC2D2B {ECO:0000305}
• Gene Name: CC2D2B {ECO:0000312|HGNC:HGNC:31666}
• Organism: Homo sapiens (Human).
• Sequence Length: 1058
• Protein Sequence: MKKSQREDIFKKMSEEMDNITAEEIIDKHLQKEENQNVAKTLRGKVREKLKISKINKGEKSSTEQLIDSEIHQRSKTEVSLDESLSFFILSGEEGSALGKSSEQRPVNRSYPKCFSLGVNLQNVAESEEEEFMKEFILTDILKVKAADYEDDQEQIKKQKANIFVPSSSPVVNQRKLPKDMMPRILEDEGFYIQRKPEIYKKTCNKMENRLLKLEEGKCWFGESGEIMSLPTPIKQSWNFRLNVRKEPLNPLLKTIYRKAVKYDLGSSFMNKMEGSREIYQLDLNIVGLQFSHHHLFNQEQVLCARLLQLYECFQDRQQQNVSQLLYEKLKALTDATKLSNENSEINQLTRKSLQDYYWQISNTKQMYDLERGKDLSLLHSILRTWKQIKSLRHGQGFTSTPIKLQVQRIKMNKCDEQEQISEMSETEKKNEGKELKNGKKLESLSYLASDETEIERIKPITLRPQLSFTAELTSLSKCSFMLRNVDARSVPGIPWLMNEQKLFEWANEVRIDPNNPEYSDLMESVTYMRLKGQDIPKYFRLEQLQDEFNFVSEEEMAKSKRFQLLQLRNAGQLDNFLLQQMPLHDTEIPDLVFQVRRLIMKRIVKISKCNLSDIVNDYEEIVSTSQLTDAVCKFVEPRRKLKPQRKERKKVTAQAISDGDIKILVRIVRAYNIPTRKTTINGSPGHDYSFSSLSKIKDNIYINIFDEMMTEKHEISGTFQVTIPPVLLGYTWSNTYVFPKEDSNEQNLKECTFLNIFATIEPQISYVTCNPTLDKFLDQTEVLQRAQIFKKNCKAMFPNRRIVTTVFNDEGIQFLVTRYIKALNPPQQLLDIFLHNSNATFDLIARFVSLIPFVPNTPDENDGSDIWMTSEHCISLAIGNKEEHAILLCNFFLYFGKKALVLLGTSVLEGHVAYVVTQETNEYLLWNPSTGQCYKQFDPFCPLKSVDCLFDDRNVWFNIQQNNTPMAVFFDYSKESFWKQLLPKNVQGTKIQSIQVTGFPIQMPYIDVQSIIDAVYQTGIHSAEFPQTEFALAVYIHPYPNNILSVWVYLASLVQHQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MKKSQREDI ------CCHHHHHHH	7.15	26074081
2	Phosphorylation	------MKKSQREDI ------CCHHHHHHH	7.15	26074081
6 (in isoform 4)	Phosphorylation	-	39.21	28270605
13 (in isoform 4)	Phosphorylation	-	10.68	28270605
14	Phosphorylation	EDIFKKMSEEMDNIT HHHHHHHHHHHHCCC	5.59	26074081
21	Phosphorylation	SEEMDNITAEEIIDK HHHHHCCCHHHHHHH	20.30	26074081
67	Phosphorylation	KSSTEQLIDSEIHQR CCCHHHHHHHHHHHC	2.66	-
71 (in isoform 4)	Phosphorylation	-	2.85	22496350
75	Phosphorylation	DSEIHQRSKTEVSLD HHHHHHCCCCEECCC	60.34	-
82	Phosphorylation	SKTEVSLDESLSFFI CCCEECCCCCEEEEE	21.65	-
110	Phosphorylation	EQRPVNRSYPKCFSL CCCCCCCCCCCCCCC	13.22	24719451
116	Phosphorylation	RSYPKCFSLGVNLQN CCCCCCCCCCCCCHH	1.62	22468782
127	Phosphorylation	NLQNVAESEEEEFMK CCHHCCHHHHHHHHH	56.79	22468782
732	Phosphorylation	PPVLLGYTWSNTYVF CCEEEEEEEECEEEE		28787133
736	Phosphorylation	LGYTWSNTYVFPKED EEEEEECEEEECCCC		28787133
818	Phosphorylation	EGIQFLVTRYIKALN HHHHHHHHHHHHHHC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of C2D2B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of C2D2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of C2D2B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of C2D2B_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.