GBP7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBP7_HUMAN
• UniProt AC: Q8N8V2
• Protein Name: Guanylate-binding protein 7
• Gene Name: GBP7
• Organism: Homo sapiens (Human).
• Sequence Length: 638
• Subcellular Localization: Membrane .
• Protein Description: Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity)..
• Protein Sequence: MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDVAGSIFIAALPGAAKLVDLGMKILSSLCNRLRNPGKKIIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	AIVGLYRTGKSYLMN EEEEHHHHCHHHHHH	35.09	23312004
52	Phosphorylation	GLYRTGKSYLMNKLA EHHHHCHHHHHHHHC	25.50	24719451
53	Phosphorylation	LYRTGKSYLMNKLAG HHHHCHHHHHHHHCC	17.29	23312004
87	Phosphorylation	MWCVPHPSKPNHTLI EEEEECCCCCCCEEE	58.68	27542207
92	Phosphorylation	HPSKPNHTLILLDTE CCCCCCCEEEEECCC	23.33	27542207
128	Phosphorylation	LLSSSFVYNSMGTIN HHHCCHHHCCCCCCC	10.25	-
199	Phosphorylation	HPITEDEYLENALKL CCCCCHHHHHHHHHH	31.47	-
270	Phosphorylation	MQSENFCSYIFTHAK CCCCHHHHHHHHCCC	19.68	24461736
271	Phosphorylation	QSENFCSYIFTHAKT CCCHHHHHHHHCCCC	10.96	24461736
376	Phosphorylation	EYSFKDKSQEFQKKL HHCCCCCCHHHHHHH	45.11	29449344
382	Acetylation	KSQEFQKKLVDTMEK CCHHHHHHHHHHHHH	42.85	164363
386	Phosphorylation	FQKKLVDTMEKKKED HHHHHHHHHHHHHHH	21.54	23882029
389	Acetylation	KLVDTMEKKKEDFVL HHHHHHHHHHHHHCC	59.32	19827625
402	Phosphorylation	VLQNEEASAKYCQAE CCCCHHHHHHHHHHH	28.68	26074081
405	Phosphorylation	NEEASAKYCQAELKR CHHHHHHHHHHHHHH	6.90	26074081
418	Phosphorylation	KRLSELLTESISRGT HHHHHHHHHHHHCCC	40.07	-
420	Phosphorylation	LSELLTESISRGTFF HHHHHHHHHHCCCEE	22.19	28555341
435	Phosphorylation	VPGGHNIYLEAKKKI CCCCCEEEEEEHHHH	12.10	-
446	Phosphorylation	KKKIEQDYTLVPRKG HHHHCCCCCCCCCCC	11.15	29523821
447	Phosphorylation	KKIEQDYTLVPRKGV HHHCCCCCCCCCCCC	29.57	29523821
541	Phosphorylation	MERERENYMRELRKM HHHHHHHHHHHHHHH	7.87	29449344
550	Phosphorylation	RELRKMLSHKMKVLE HHHHHHHHHHHHHHH	19.98	29083192
554	Acetylation	KMLSHKMKVLEELLT HHHHHHHHHHHHHHH	48.77	18530639

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBP7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBP7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBP7_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GBP7_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.