GBP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBP3_HUMAN
• UniProt AC: Q9H0R5
• Protein Name: Guanylate-binding protein 3
• Gene Name: GBP3
• Organism: Homo sapiens (Human).
• Sequence Length: 595
• Subcellular Localization: Cytoplasm . Cytoplasm, perinuclear region . Golgi apparatus membrane . Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP-5, at
• Protein Description: Exhibits antiviral activity against influenza virus..
• Protein Sequence: MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	AIVGLYRTGKSYLMN EEEEHHHHCHHHHHH	35.09	23312004
52	Phosphorylation	GLYRTGKSYLMNKLA EHHHHCHHHHHHHHC	25.50	24719451
53	Phosphorylation	LYRTGKSYLMNKLAG HHHHCHHHHHHHHCC	17.29	23312004
66	Phosphorylation	AGKNKGFSLGSTVKS CCCCCCCCCCHHCHH	40.25	30624053
69	Phosphorylation	NKGFSLGSTVKSHTK CCCCCCCHHCHHCCC	35.01	30624053
70	Phosphorylation	KGFSLGSTVKSHTKG CCCCCCHHCHHCCCE	30.10	30624053
73	Phosphorylation	SLGSTVKSHTKGIWM CCCHHCHHCCCEEEE	31.86	30624053
75	Phosphorylation	GSTVKSHTKGIWMWC CHHCHHCCCEEEEEE	37.75	30624053
154	Phosphorylation	ELTHRIRSKSSPDEN HHHHHHHCCCCCCCC	34.22	-
156	Phosphorylation	THRIRSKSSPDENEN HHHHHCCCCCCCCCC	48.64	28655764
157	Phosphorylation	HRIRSKSSPDENENE HHHHCCCCCCCCCCC	39.86	-
180	Ubiquitination	FPDFVWTLRDFSLDL CHHHHHHHHHHCCCC	2.65	24816145
203	Phosphorylation	PDEYLEYSLKLTQGT HHHHHHHEEECCCCC	15.06	24719451
261	Ubiquitination	EELDPEFVQQVADFC CCCCHHHHHHHHHHH	3.57	24816145
276	Ubiquitination	SYIFSNSKTKTLSGG HHHHCCCCCCEECCC	59.29	-
298	Phosphorylation	LESLVLTYINAISRG HHHHHHHHHHHHHCC	6.50	-
303	Phosphorylation	LTYINAISRGDLPCM HHHHHHHHCCCCCHH	28.00	-
314	Ubiquitination	LPCMENAVLALAQIE CCHHHHHHHHHHHHC	4.91	24816145
316	Ubiquitination	CMENAVLALAQIENS HHHHHHHHHHHHCCH	8.34	24816145
333	Phosphorylation	VQKAIAHYDQQMGQK HHHHHHHHHHHCCCC	13.36	23401153
368	Ubiquitination	EATEVYMKNSFKDVD HCHHHHHHCCCCCHH	31.58	24816145
395	Ubiquitination	KKRDDFCKQNQEASS HHHHHHHHHHHHHCH	52.88	24816145
401	Phosphorylation	CKQNQEASSDRCSAL HHHHHHHCHHHHHHH	31.83	28348404
402	Phosphorylation	KQNQEASSDRCSALL HHHHHHCHHHHHHHH	35.80	28348404
406	Phosphorylation	EASSDRCSALLQVIF HHCHHHHHHHHHHHH	23.89	28348404
417	Ubiquitination	QVIFSPLEEEVKAGI HHHHCCCHHHHHCCC	56.34	29967540
451	Ubiquitination	KYYEEPRKGIQAEEI HHHHCCCCCCCHHHH	71.70	-
462	Phosphorylation	AEEILQTYLKSKESV HHHHHHHHHHCCCCH	10.12	-
472	Ubiquitination	SKESVTDAILQTDQI CCCCHHHHHHHHHHH	8.60	29967540
518	Acetylation	YQQMMEEKEKSYQEH HHHHHHHHHHHHHHH	58.07	7933709
520	Acetylation	QMMEEKEKSYQEHVK HHHHHHHHHHHHHHH	66.58	7933717
521	Phosphorylation	MMEEKEKSYQEHVKQ HHHHHHHHHHHHHHH	32.89	25072903
522	Phosphorylation	MEEKEKSYQEHVKQL HHHHHHHHHHHHHHH	29.05	25072903
530	Phosphorylation	QEHVKQLTEKMERER HHHHHHHHHHHHHHH	30.94	25072903
547	Phosphorylation	LLEEQEKTLTSKLQE HHHHHHHHHHHHHHH	34.22	-
550	Phosphorylation	EQEKTLTSKLQEQAR HHHHHHHHHHHHHHH	34.19	-
551	Ubiquitination	QEKTLTSKLQEQARV HHHHHHHHHHHHHHH	49.29	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
M4K4_HUMAN	MAP4K4	physical	12387898

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.