SCTR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCTR_HUMAN
• UniProt AC: P47872
• Protein Name: Secretin receptor
• Gene Name: SCTR
• Organism: Homo sapiens (Human).
• Sequence Length: 440
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase..
• Protein Sequence: MRPHLSPPLQQLLLPVLLACAAHSTGALPRLCDVLQVLWEEQDQCLQELSREQTGDLGTEQPVPGCEGMWDNISCWPSSVPGRMVEVECPRFLRMLTSRNGSLFRNCTQDGWSETFPRPNLACGVNVNDSSNEKRHSYLLKLKVMYTVGYSSSLVMLLVALGILCAFRRLHCTRNYIHMHLFVSFILRALSNFIKDAVLFSSDDVTYCDAHRAGCKLVMVLFQYCIMANYSWLLVEGLYLHTLLAISFFSERKYLQGFVAFGWGSPAIFVALWAIARHFLEDVGCWDINANASIWWIIRGPVILSILINFILFINILRILMRKLRTQETRGNEVSHYKRLARSTLLLIPLFGIHYIVFAFSPEDAMEIQLFFELALGSFQGLVVAVLYCFLNGEVQLEVQKKWQQWHLREFPLHPVASFSNSTKASHLEQSQGTCRTSII

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	N-linked_Glycosylation	GCEGMWDNISCWPSS CCCCCCCCCCCCCCC	16.74	10537138
72	N-linked_Glycosylation	GCEGMWDNISCWPSS CCCCCCCCCCCCCCC	16.74	10537138
74	O-linked_Glycosylation	EGMWDNISCWPSSVP CCCCCCCCCCCCCCC	19.18	-
74	O-linked_Glycosylation	EGMWDNISCWPSSVP CCCCCCCCCCCCCCC	19.18	10537138
100	N-linked_Glycosylation	LRMLTSRNGSLFRNC HHHHHCCCCCCCCCC	44.14	UniProtKB CARBOHYD
106	N-linked_Glycosylation	RNGSLFRNCTQDGWS CCCCCCCCCCCCCCC	26.34	UniProtKB CARBOHYD
128	N-linked_Glycosylation	LACGVNVNDSSNEKR EEEEEECCCCCCCHH	37.94	UniProtKB CARBOHYD
137	Phosphorylation	SSNEKRHSYLLKLKV CCCCHHHHHEEHHEE	22.85	24719451
138	Phosphorylation	SNEKRHSYLLKLKVM CCCHHHHHEEHHEEH	15.21	24719451
146	Phosphorylation	LLKLKVMYTVGYSSS EEHHEEHHHCCCCHH	10.97	24043423
147	Phosphorylation	LKLKVMYTVGYSSSL EHHEEHHHCCCCHHH	6.86	24043423
150	Phosphorylation	KVMYTVGYSSSLVML EEHHHCCCCHHHHHH	10.88	24043423
151	Phosphorylation	VMYTVGYSSSLVMLL EHHHCCCCHHHHHHH	13.92	24043423
152	Phosphorylation	MYTVGYSSSLVMLLV HHHCCCCHHHHHHHH	21.14	24043423
153	Phosphorylation	YTVGYSSSLVMLLVA HHCCCCHHHHHHHHH	21.02	24043423
291	N-linked_Glycosylation	GCWDINANASIWWII CCEECCCCCEEHHHH	29.72	UniProtKB CARBOHYD
418	Phosphorylation	FPLHPVASFSNSTKA CCCCCCEECCCCCCH	29.46	-
420	Phosphorylation	LHPVASFSNSTKASH CCCCEECCCCCCHHH	27.63	-
422	Phosphorylation	PVASFSNSTKASHLE CCEECCCCCCHHHHH	30.04	-
423	Phosphorylation	VASFSNSTKASHLEQ CEECCCCCCHHHHHH	34.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCTR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCTR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCTR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SECR_HUMAN	SCT	physical	9440501
PACA_HUMAN	ADCYAP1	physical	1335692
CPMD8_HUMAN	CPAMD8	physical	1335692

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D02021: Secretin (JAN/USAN/INN); Chirhostim (TN); Secrepan (TN)
• DrugBank
• DB00021: Secretin