CPMD8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CPMD8_HUMAN
• UniProt AC: Q8IZJ3
• Protein Name: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 {ECO:0000303|PubMed:15177561}
• Gene Name: CPAMD8 {ECO:0000312|HGNC:HGNC:23228}
• Organism: Homo sapiens (Human).
• Sequence Length: 1885
• Subcellular Localization: Secreted . Cell membrane ; Peripheral membrane protein ; Extracellular side .
• Protein Sequence: MSGALLWPLLPLLLLLLSARDGVRAAQPQAPGYLIAAPSVFRAGVEEVISVTIFNSPREVTVQAQLVAQGEPVVQSQGAILDKGTIKLKVPTGLRGQALLKVWGRGWQAEEGPLFHNQTSVTVDGRGASVFIQTDKPVYRPQHRVLISIFTVSPNLRPVNEKLEAYILDPRGSRMIEWRHLKPFCCGITNMSFPLSDQPVLGEWFIFVEMQGHAYNKSFEVQKYVLPKFELLIDPPRYIQDLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYSHEVGRPVLRTTKILGSRDFDICVRDMIPADVPEHFRGRVSIWAMVTSVDGSQQVAFDDSTPVQRQLVDIRYSKDTRKQFKPGLAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYTSEVVSQRGLVGFEIPSIPTSAQHVWLETKVMALNGKPVGAQYLPSYLSLGSWYSPSQCYLQLQPPSHPLQVGEEAYFSVKSTCPCNFTLYYEVAARGNIVLSGQQPAHTTQQRSKRAAPALEKPIRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRENGEGVADSLQFAVETFFENQVSVTYSANETQPGEVVDLRIRAARGSCVCVAAVDKSVYLLRSGFRLTPAQVFQELEDYDVSDSFGVSREDGPFWWAGLTAQRRRRSSVFPWPWGITKDSGFAFTETGLVVMTDRVSLNHRQDGGLYTDEAVPAFQPHTGSLVAVAPSRHPPRTEKRKRTFFPETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGIAEPSLLKTFKPFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFVGHPGKRHVTKKMCVAPGEAEPIWVVLSFSDLGLNNITAKALAYGDTNCCRDGRSSKHPEENHADRRVPIGVDHVRRSVMVEAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYVQRPLRLTRFDVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASAHTAKILSWDEFRTFWISWRGGLIQVGHGPEPSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKMEVDESYSEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVALLETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYALTLLRSPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYKVMLEVCTRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNEVERAPARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVVYASACRLREAACRQAAPLEPAPPSCCALEQRLPASSSSTYGDDLASVAPGPLQQDVKLNGAGLEVEDSDPEPEGEAEDRVTAGPRPPVSSGNLESSTQSASPFHRWGQTPAPQRHSGRVVGAHRPGLLSPVFVYSPAFQSGGEEGLWMSNTCTLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGALLWPL ------CCCHHHHHH	44.04	24043423
18	Phosphorylation	PLLLLLLSARDGVRA HHHHHHHHCCCCCCC	22.64	24719451
33	Phosphorylation	AQPQAPGYLIAAPSV CCCCCCCEEEECCHH	8.22	24719451
39	Phosphorylation	GYLIAAPSVFRAGVE CEEEECCHHHHCCCC	29.21	24719451
52	Phosphorylation	VEEVISVTIFNSPRE CCEEEEEEEECCCCE	17.04	23532336
56	Phosphorylation	ISVTIFNSPREVTVQ EEEEEECCCCEEEEE	18.00	23532336
117	N-linked_Glycosylation	EEGPLFHNQTSVTVD CCCCCCCCCEEEEEC	39.22	UniProtKB CARBOHYD
190	N-linked_Glycosylation	PFCCGITNMSFPLSD CEECCCEECCCCCCC	23.37	UniProtKB CARBOHYD
267	N-linked_Glycosylation	VAGALMINMTVNGVG EEEEEEEEEEECCCC	13.20	UniProtKB CARBOHYD
269	Phosphorylation	GALMINMTVNGVGYY EEEEEEEEECCCCCC	13.31	-
328	Phosphorylation	MVTSVDGSQQVAFDD EEEEECCCCEEECCC	16.99	22210691
362	Phosphorylation	QFKPGLAYVGKVELS HCCCCEEEEEEEEEE	18.12	-
396	Phosphorylation	PKDNIYTSEVVSQRG CCCCEEEEEEECCCC	16.06	-
400	Phosphorylation	IYTSEVVSQRGLVGF EEEEEEECCCCCCCE	21.24	-
624	Phosphorylation	AAVDKSVYLLRSGFR EEECCCEEEHHCCCC	13.70	20090780
644	Phosphorylation	VFQELEDYDVSDSFG HHHHHHCCCCCCCCC	14.63	24043423
647	Phosphorylation	ELEDYDVSDSFGVSR HHHCCCCCCCCCCCC	25.33	24043423
649	Phosphorylation	EDYDVSDSFGVSRED HCCCCCCCCCCCCCC	19.18	24043423
653	Phosphorylation	VSDSFGVSREDGPFW CCCCCCCCCCCCCCE	30.26	24043423
665	Phosphorylation	PFWWAGLTAQRRRRS CCEECCCCCHHHHHC	21.59	-
712	Phosphorylation	HRQDGGLYTDEAVPA CCCCCCCCCCCCCCC	18.54	24043423
713	Phosphorylation	RQDGGLYTDEAVPAF CCCCCCCCCCCCCCC	32.19	24043423
724	Phosphorylation	VPAFQPHTGSLVAVA CCCCCCCCCCEEEEC	34.84	24043423
726	Phosphorylation	AFQPHTGSLVAVAPS CCCCCCCCEEEECCC	22.33	24043423
733	Phosphorylation	SLVAVAPSRHPPRTE CEEEECCCCCCCCCH	33.22	24043423
757	N-linked_Glycosylation	TWIWHCLNISDPSGE HHEEEECCCCCCCCC	36.79	UniProtKB CARBOHYD
797	Phosphorylation	GLGIAEPSLLKTFKP CCCCCCHHHHHHCCH	37.53	24719451
826	Phosphorylation	EQVKIPLSVYNYMGT CEEEECEEHEECCCC	19.73	22468782
830	Phosphorylation	IPLSVYNYMGTCAEV ECEEHEECCCCCCHH	4.53	22468782
833	Phosphorylation	SVYNYMGTCAEVYMK EHEECCCCCCHHHHH	7.63	22468782
842	Phosphorylation	AEVYMKLSVPKGIQF CHHHHHHCCCCCCEE	30.75	24719451
1028	Ubiquitination	VASAHTAKILSWDEF CCCCCCEEECCHHHH	45.39	-
1041	Phosphorylation	EFRTFWISWRGGLIQ HHHEEEEEECCCEEE	11.00	24719451
1121	Phosphorylation	GSERATASIIGDVMG CCHHHHHHHHHHHHH	15.47	-
1144	S-palmitoylation	LLRLPFGCGEQNMIH HHCCCCCCCCCCCEE	5.77	29575903
1189	Phosphorylation	QGYQRQLTYKRQDGS HHHHEEEEEECCCCC	20.75	-
1190	Phosphorylation	GYQRQLTYKRQDGSY HHHEEEEEECCCCCC	16.86	-
1439	N-linked_Glycosylation	LSYAGGINLTVSLAS HHHCCCEEEEEEEEC	32.69	UniProtKB CARBOHYD
1467	Phosphorylation	TNQKVLQTAAIPSLP CCHHHHHHCCCCCCC	17.56	-
1613	Phosphorylation	AGRRVLFYFDEIPSR CCEEEEEEECCCCHH	13.13	18083107
1776	O-linked_Glycosylation	TYGDDLASVAPGPLQ CCCCCHHHCCCCCCC	26.55	OGP
1839	Phosphorylation	PFHRWGQTPAPQRHS CCCCCCCCCCCCCCC	19.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CPMD8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CPMD8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CPMD8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SCTR_HUMAN	SCTR	physical	1335692

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.