KI2L1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KI2L1_HUMAN
• UniProt AC: P43626
• Protein Name: Killer cell immunoglobulin-like receptor 2DL1
• Gene Name: KIR2DL1
• Organism: Homo sapiens (Human).
• Sequence Length: 348
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein.
• Protein Description: Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis..
• Protein Sequence: MSLLVVSMACVGFFLLQGAWPHEGVHRKPSLLAHPGPLVKSEETVILQCWSDVMFEHFLLHREGMFNDTLRLIGEHHDGVSKANFSISRMTQDLAGTYRCYGSVTHSPYQVSAPSDPLDIVIIGLYEKPSLSAQPGPTVLAGENVTLSCSSRSSYDMYHLSREGEAHERRLPAGPKVNGTFQADFPLGPATHGGTYRCFGSFHDSPYEWSKSSDPLLVSVTGNPSNSWPSPTEPSSKTGNPRHLHILIGTSVVIILFILLFFLLHRWCSNKKNAAVMDQESAGNRTANSEDSDEQDPQEVTYTQLNHCVFTQRKITRPSQRPKTPPTDIIVYTELPNAESRSKVVSCP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	HPGPLVKSEETVILQ CCCCCCCCCCEEEEH	32.93	-
44	Phosphorylation	PLVKSEETVILQCWS CCCCCCCEEEEHHHH	14.59	-
51	Phosphorylation	TVILQCWSDVMFEHF EEEEHHHHHHHHHHH	28.14	-
67	N-linked_Glycosylation	LHREGMFNDTLRLIG HHCCCCCHHHHHHHH	32.25	UniProtKB CARBOHYD
84	N-linked_Glycosylation	HDGVSKANFSISRMT CCCHHHCCEEHHHCC	34.63	UniProtKB CARBOHYD
86	Phosphorylation	GVSKANFSISRMTQD CHHHCCEEHHHCCHH	21.33	-
97	Phosphorylation	MTQDLAGTYRCYGSV CCHHCCCCEEEEEEE	11.37	-
144	N-linked_Glycosylation	PTVLAGENVTLSCSS CEEECCCCEEEEECC	31.02	UniProtKB CARBOHYD
178	N-linked_Glycosylation	LPAGPKVNGTFQADF CCCCCCCCCEEEECC	50.33	UniProtKB CARBOHYD
180	Phosphorylation	AGPKVNGTFQADFPL CCCCCCCEEEECCCC	13.84	-
254 (in isoform 2)	Phosphorylation	-	1.81	22210691
255 (in isoform 2)	Phosphorylation	-	1.41	22210691
256 (in isoform 2)	Phosphorylation	-	1.18	22210691
281	Phosphorylation	AAVMDQESAGNRTAN CEEECHHHCCCCCCC	35.52	-
289	Phosphorylation	AGNRTANSEDSDEQD CCCCCCCCCCCCCCC	40.07	-
292	Phosphorylation	RTANSEDSDEQDPQE CCCCCCCCCCCCCCC	38.71	-
302	Phosphorylation	QDPQEVTYTQLNHCV CCCCCCHHHHHCCEE	9.54	18083107
311	Phosphorylation	QLNHCVFTQRKITRP HHCCEEEECCCCCCH	13.68	-
319	Phosphorylation	QRKITRPSQRPKTPP CCCCCCHHHCCCCCC	35.21	-
327	Phosphorylation	QRPKTPPTDIIVYTE HCCCCCCCCEEEEEE	40.82	22210691
332	Phosphorylation	PPTDIIVYTELPNAE CCCCEEEEEECCCCH	5.54	-
340	Phosphorylation	TELPNAESRSKVVSC EECCCCHHHCCCCCC	39.17	22210691
342	Phosphorylation	LPNAESRSKVVSCP- CCCCHHHCCCCCCC-	38.80	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KI2L1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KI2L1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KI2L1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1C07_HUMAN	HLA-C	physical	12454284
1C07_HUMAN	HLA-C	physical	11163076
1C07_HUMAN	HLA-C	physical	11323700

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D10444: Lirilumab (USAN/INN)
• DrugBank
• There are no disease associations of PTM sites.