KI2L3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KI2L3_HUMAN
• UniProt AC: P43628
• Protein Name: Killer cell immunoglobulin-like receptor 2DL3
• Gene Name: KIR2DL3
• Organism: Homo sapiens (Human).
• Sequence Length: 341
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis..
• Protein Sequence: MSLMVVSMVCVGFFLLQGAWPHEGVHRKPSLLAHPGPLVKSEETVILQCWSDVRFQHFLLHREGKFKDTLHLIGEHHDGVSKANFSIGPMMQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSRSSYDMYHLSREGEAHERRFSAGPKVNGTFQADFPLGPATHGGTYRCFGSFRDSPYEWSNSSDPLLVSVTGNPSNSWPSPTEPSSETGNPRHLHVLIGTSVVIILFILLLFFLLHRWCCNKKNAVVMDQEPAGNRTVNREDSDEQDPQEVTYAQLNHCVFTQRKITRPSQRPKTPPTDIIVYTELPNAEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	HPGPLVKSEETVILQ CCCCCCCCCCEEEEE	32.93	-
44	Phosphorylation	PLVKSEETVILQCWS CCCCCCCEEEEEEEC	14.59	-
51	Phosphorylation	TVILQCWSDVRFQHF EEEEEEECHHHHHHH	33.58	-
84	N-linked_Glycosylation	HDGVSKANFSIGPMM CCCCCCCCCCCCHHH	34.63	UniProtKB CARBOHYD
86	Phosphorylation	GVSKANFSIGPMMQD CCCCCCCCCCHHHHH	26.83	-
98	Phosphorylation	MQDLAGTYRCYGSVT HHHHCCCEEEEEEEC	9.58	-
101	Phosphorylation	LAGTYRCYGSVTHSP HCCCEEEEEEECCCC	11.93	18083107
109	Phosphorylation	GSVTHSPYQLSAPSD EEECCCCCCCCCCCC	25.71	18083107
126	Phosphorylation	DIVITGLYEKPSLSA CEEEEECCCCCCCCC	24.21	18083107
138	Phosphorylation	LSAQPGPTVLAGESV CCCCCCCEEECCCCE	33.78	-
150	Phosphorylation	ESVTLSCSSRSSYDM CCEEEECCCCCCEEC	25.96	-
151	Phosphorylation	SVTLSCSSRSSYDMY CEEEECCCCCCEECE	40.27	-
178	N-linked_Glycosylation	FSAGPKVNGTFQADF CCCCCCCCCEEEECC	50.33	UniProtKB CARBOHYD
180	Phosphorylation	AGPKVNGTFQADFPL CCCCCCCEEEECCCC	13.84	-
205	Phosphorylation	CFGSFRDSPYEWSNS ECCCCCCCCCCCCCC	25.73	23663014
207	Phosphorylation	GSFRDSPYEWSNSSD CCCCCCCCCCCCCCC	33.70	23663014
210	Phosphorylation	RDSPYEWSNSSDPLL CCCCCCCCCCCCCEE	18.20	23663014
211	N-linked_Glycosylation	DSPYEWSNSSDPLLV CCCCCCCCCCCCEEE	46.75	UniProtKB CARBOHYD
212	Phosphorylation	SPYEWSNSSDPLLVS CCCCCCCCCCCEEEE	30.51	23663014
213	Phosphorylation	PYEWSNSSDPLLVSV CCCCCCCCCCEEEEE	47.71	23663014
219	Phosphorylation	SSDPLLVSVTGNPSN CCCCEEEEECCCCCC	17.58	23663014
221	Phosphorylation	DPLLVSVTGNPSNSW CCEEEEECCCCCCCC	24.60	23663014
312	Phosphorylation	QLNHCVFTQRKITRP HHHCCEEEECCCCCH	13.68	-
320	Phosphorylation	QRKITRPSQRPKTPP ECCCCCHHHCCCCCC	35.21	-
333	Phosphorylation	PPTDIIVYTELPNAE CCCCEEEEEECCCCC	5.54	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KI2L3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KI2L3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KI2L3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1C07_HUMAN	HLA-C	physical	8692965
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.