CORO6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CORO6_HUMAN
• UniProt AC: Q6QEF8
• Protein Name: Coronin-6
• Gene Name: CORO6
• Organism: Homo sapiens (Human).
• Sequence Length: 472
• Protein Sequence: MSRRVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGRVDKNYPLVTGHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLDDMHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAEQARPHEGARPLRAVFTADGKLLSTGFSRMSERQLALWDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVHYLNTFSSKEPQRGMGFMPKRGLDVSKCEIARFYKLHERKCEPIIMTVPRKSDLFQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLRDGYVPPKHRELRVTKRNILDVRPPSGPRRSQSASDAPLSQQHTLETLLEEIKALRERVQAQEQRITALENMLCELVDGTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSRRVVRQS ------CCHHHHHHH	28.88	22210691
188 (in isoform 4)	Phosphorylation	-	25.18	26437602
190 (in isoform 4)	Phosphorylation	-	4.21	26437602
228 (in isoform 5)	Phosphorylation	-	19.76	20068231
235 (in isoform 5)	Phosphorylation	-	36.60	20068231
236	Phosphorylation	ADGKLLSTGFSRMSE CCCCEEECCCCCCCH	42.06	23612710
236 (in isoform 5)	Phosphorylation	-	42.06	20068231
236 (in isoform 3)	Phosphorylation	-	42.06	26437602
238 (in isoform 3)	Phosphorylation	-	4.19	26437602
239	Phosphorylation	KLLSTGFSRMSERQL CEEECCCCCCCHHHH	28.55	20068231
239 (in isoform 5)	Phosphorylation	-	28.55	20068231
242 (in isoform 5)	Phosphorylation	-	28.63	20068231
312	Acetylation	YLNTFSSKEPQRGMG EECCCCCCCCCCCCC	72.69	26051181
338	Ubiquitination	CEIARFYKLHERKCE HHHHHHHHHHHCCCE	40.43	-
338	Acetylation	CEIARFYKLHERKCE HHHHHHHHHHHCCCE	40.43	26051181
344	S-nitrosylation	YKLHERKCEPIIMTV HHHHHCCCEEEEEEC	10.61	2212679
417	Phosphorylation	ILDVRPPSGPRRSQS EECCCCCCCCCCCCC	65.20	16674116
422	Phosphorylation	PPSGPRRSQSASDAP CCCCCCCCCCCCCCC	29.75	22673903
424	Phosphorylation	SGPRRSQSASDAPLS CCCCCCCCCCCCCCC	30.87	22673903
426	Phosphorylation	PRRSQSASDAPLSQQ CCCCCCCCCCCCCHH	39.28	22673903
431	Phosphorylation	SASDAPLSQQHTLET CCCCCCCCHHHHHHH	27.08	22673903
435	Phosphorylation	APLSQQHTLETLLEE CCCCHHHHHHHHHHH	23.19	22673903
438	Phosphorylation	SQQHTLETLLEEIKA CHHHHHHHHHHHHHH	39.49	27542207

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CORO6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CORO6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CORO6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COR1A_HUMAN	CORO1A	physical	28514442
COR1C_HUMAN	CORO1C	physical	28514442
UACA_HUMAN	UACA	physical	28514442
TARA_HUMAN	TRIOBP	physical	28514442
TACC3_HUMAN	TACC3	physical	28514442
NBR1_HUMAN	NBR1	physical	28514442
COR1B_HUMAN	CORO1B	physical	28514442
POC1A_HUMAN	POC1A	physical	28514442
CSR2B_HUMAN	CSRP2BP	physical	28514442
CI016_HUMAN	C9orf16	physical	28514442
TIGD5_HUMAN	TIGD5	physical	28514442
PCGF6_HUMAN	PCGF6	physical	28514442
TNIP1_HUMAN	TNIP1	physical	28514442
IFT81_HUMAN	IFT81	physical	28514442
ZN318_HUMAN	ZNF318	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-338, AND MASS SPECTROMETRY.
PubMed: 19608861