SYCE3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYCE3_HUMAN
• UniProt AC: A1L190
• Protein Name: Synaptonemal complex central element protein 3
• Gene Name: SYCE3
• Organism: Homo sapiens (Human).
• Sequence Length: 88
• Subcellular Localization: Nucleus . Chromosome . Colocalizes with SYCE1 in the central elements.
• Protein Description: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility..
• Protein Sequence: MDDADPEERNYDNMLKMLSDLNKDLEKLLEEMEKISVQATWMAYDMVVMRTNPTLAESMRRLEDAFVNCKEEMEKNWQELLHETKQRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	ADPEERNYDNMLKML CCHHHHCHHHHHHHH	18.21	22210691
19	Phosphorylation	DNMLKMLSDLNKDLE HHHHHHHHHHHHHHH	36.23	26074081
36	Phosphorylation	LEEMEKISVQATWMA HHHHHHHHHHHHHHH	21.17	21214269
44	Phosphorylation	VQATWMAYDMVVMRT HHHHHHHHHHHHHCC	6.62	21214269
54	Phosphorylation	VVMRTNPTLAESMRR HHHCCCHHHHHHHHH	40.44	21214269
58	Phosphorylation	TNPTLAESMRRLEDA CCHHHHHHHHHHHHH	16.39	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYCE3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYCE3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYCE3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CENPE_HUMAN	CENPE	physical	28514442
M3K15_HUMAN	MAP3K15	physical	28514442
SCLT1_HUMAN	SCLT1	physical	28514442
NIN_HUMAN	NIN	physical	28514442
SAS6_HUMAN	SASS6	physical	28514442
MTG8_HUMAN	RUNX1T1	physical	28514442
PRDM6_HUMAN	PRDM6	physical	28514442
KIFC3_HUMAN	KIFC3	physical	28514442
KIZ_HUMAN	KIZ	physical	28514442
PX11B_HUMAN	PEX11B	physical	28514442
FEM1B_HUMAN	FEM1B	physical	28514442
HAUS3_HUMAN	HAUS3	physical	28514442
RBCC1_HUMAN	RB1CC1	physical	28514442
LIN41_HUMAN	TRIM71	physical	28514442
SPAG5_HUMAN	SPAG5	physical	28514442
HOOK3_HUMAN	HOOK3	physical	28514442
CNTRL_HUMAN	CNTRL	physical	28514442
UBB_HUMAN	UBB	physical	28514442
HAUS4_HUMAN	HAUS4	physical	28514442
YIPF3_HUMAN	YIPF3	physical	28514442
CAMP2_HUMAN	CAMSAP2	physical	28514442
HOME1_HUMAN	HOMER1	physical	28514442
SKAP_HUMAN	KNSTRN	physical	28514442
CSN2_HUMAN	COPS2	physical	28514442
HAUS5_HUMAN	HAUS5	physical	28514442
ZWINT_HUMAN	ZWINT	physical	28514442
TIF1A_HUMAN	TRIM24	physical	28514442
HAUS2_HUMAN	HAUS2	physical	28514442
OMA1_HUMAN	OMA1	physical	28514442
CENPH_HUMAN	CENPH	physical	28514442
COG6_HUMAN	COG6	physical	28514442
CE164_HUMAN	CEP164	physical	28514442
HBAZ_HUMAN	HBZ	physical	28514442
CSN7B_HUMAN	COPS7B	physical	28514442
ABCBA_HUMAN	ABCB10	physical	28514442
OCAD1_HUMAN	OCIAD1	physical	28514442
VPS53_HUMAN	VPS53	physical	28514442
CUL2_HUMAN	CUL2	physical	28514442
CSN6_HUMAN	COPS6	physical	28514442
RER1_HUMAN	RER1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.