AACS_HUMAN - dbPTM
AACS_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AACS_HUMAN
UniProt AC Q86V21
Protein Name Acetoacetyl-CoA synthetase
Gene Name AACS
Organism Homo sapiens (Human).
Sequence Length 672
Subcellular Localization Cytoplasm, cytosol.
Protein Description Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity)..
Protein Sequence MSKEERPGREEILECQVMWEPDSKKNTQMDRFRAAVGAACGLALESYDDLYHWSVESYSDFWAEFWKFSGIVFSRVYDEVVDTSKGIADVPEWFKGSRLNYAENLLRHKENDRVALYIAREGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGDRVVGYLPNSEHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHNHMEKLQQVVKGLPDLKKVVVIPYVSSRENIDLSKIPNSVFLDDFLATGTSEQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVGWMMWNWMVSLLATGAAMVLYDGSPLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEEKAMKPVETHSLQMLHTILSTGSPLKAQSYEYVYRCIKSSILLGSISGGTDIISCFMGHNFSLPVYKGEIQARNLGMAVEAWNEEGKAVWGESGELVCTKPIPCQPTHFWNDENGNKYRKAYFSKFPGIWAHGDYCRINPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERVILFLKMASGHAFQPDLVKRIRDAIRMGLSARHVPSLILETKGIPYTLNGKKVEVAVKQIIAGKAVEQGGAFSNPETLDLYRDIPELQGF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7 (in isoform 3)Phosphorylation-49.8525159151
10 (in isoform 3)Phosphorylation-56.1325159151
46PhosphorylationACGLALESYDDLYHW
HHHHHHHCCCCCCCC		34.4124043423
47PhosphorylationCGLALESYDDLYHWS
HHHHHHCCCCCCCCC		12.2324043423
51PhosphorylationLESYDDLYHWSVESY
HHCCCCCCCCCCCCC		14.2924043423
54PhosphorylationYDDLYHWSVESYSDF
CCCCCCCCCCCCHHH		11.6024043423
57PhosphorylationLYHWSVESYSDFWAE
CCCCCCCCCHHHHHH		27.9924043423
58PhosphorylationYHWSVESYSDFWAEF
CCCCCCCCHHHHHHH		9.9624043423
59PhosphorylationHWSVESYSDFWAEFW
CCCCCCCHHHHHHHH		35.2924043423
85UbiquitinationDEVVDTSKGIADVPE
HHHHCCCCCCCCCCH		57.33-
95UbiquitinationADVPEWFKGSRLNYA
CCCCHHHHCCCCHHH		57.9821890473
95 (in isoform 2)Ubiquitination-57.9821890473
95 (in isoform 1)Ubiquitination-57.9821890473
97PhosphorylationVPEWFKGSRLNYAEN
CCHHHHCCCCHHHHH		33.9028857561
212PhosphorylationFSVEAVVYNGKEHNH
EEEEEEEECCCCCCH		16.1722817900
222UbiquitinationKEHNHMEKLQQVVKG
CCCCHHHHHHHHHHC		43.98-
228UbiquitinationEKLQQVVKGLPDLKK
HHHHHHHHCCCCCCE		56.74-
241PhosphorylationKKVVVIPYVSSRENI
CEEEEEEECCCCCCC		11.2270959849
243PhosphorylationVVVIPYVSSRENIDL
EEEEEECCCCCCCCH		20.1770959855
244PhosphorylationVVIPYVSSRENIDLS
EEEEECCCCCCCCHH		33.3070959861
406PhosphorylationHSLQMLHTILSTGSP
HHHHHHHHHHHCCCC		21.4724043423
409PhosphorylationQMLHTILSTGSPLKA
HHHHHHHHCCCCCCC		27.2024114839
410PhosphorylationMLHTILSTGSPLKAQ
HHHHHHHCCCCCCCC		37.9324043423
412PhosphorylationHTILSTGSPLKAQSY
HHHHHCCCCCCCCCH		27.4472262553
418PhosphorylationGSPLKAQSYEYVYRC
CCCCCCCCHHHHHHH		25.4524043423
419PhosphorylationSPLKAQSYEYVYRCI
CCCCCCCHHHHHHHH		10.1324043423
421PhosphorylationLKAQSYEYVYRCIKS
CCCCCHHHHHHHHHH		8.4424043423
423PhosphorylationAQSYEYVYRCIKSSI
CCCHHHHHHHHHHHH		10.0024043423
489AcetylationSGELVCTKPIPCQPT
CCCEEECCCCCCCCC		35.5026051181
489UbiquitinationSGELVCTKPIPCQPT
CCCEEECCCCCCCCC		35.50-
506UbiquitinationWNDENGNKYRKAYFS
EECCCCCEEEHHHHH		48.07-
524PhosphorylationGIWAHGDYCRINPKT
CCEECCCCEEECCCC		6.5553509
530UbiquitinationDYCRINPKTGGIVML
CCEEECCCCCCEEEE		56.14-
531PhosphorylationYCRINPKTGGIVMLG
CEEECCCCCCEEEEE		41.7321406692
536SulfoxidationPKTGGIVMLGRSDGT
CCCCCEEEEECCCCC		2.8721406390
540PhosphorylationGIVMLGRSDGTLNPN
CEEEEECCCCCCCCC		38.3028857561
543PhosphorylationMLGRSDGTLNPNGVR
EEECCCCCCCCCCEE		28.4928188228
578PhosphorylationCVPQYNKYREERVIL
CCCCCCCCCHHHHHE		21.4411197149
618PhosphorylationLSARHVPSLILETKG
CCCCCCCCEEEEECC		27.2730108239
624UbiquitinationPSLILETKGIPYTLN
CCEEEEECCCCEEEC		45.53-
634MalonylationPYTLNGKKVEVAVKQ
CEEECCEEEEEEEEH		45.0526320211
640UbiquitinationKKVEVAVKQIIAGKA
EEEEEEEEHHHCCCH		26.49-
646AcetylationVKQIIAGKAVEQGGA
EEHHHCCCHHHCCCC		39.9923236377
646UbiquitinationVKQIIAGKAVEQGGA
EEHHHCCCHHHCCCC		39.99-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AACS_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AACS_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AACS_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CKLF5_HUMANCMTM5physical
25416956
STAT6_HUMANSTAT6physical
26344197
UN13D_HUMANUNC13Dphysical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AACS_HUMAN

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Related Literatures of Post-Translational Modification

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