KLK6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLK6_HUMAN
• UniProt AC: Q92876
• Protein Name: Kallikrein-6
• Gene Name: KLK6
• Organism: Homo sapiens (Human).
• Sequence Length: 244
• Subcellular Localization: Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into
• Protein Description: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis..
• Protein Sequence: MKKLMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPLERDCSANTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTIQAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
134	N-linked_Glycosylation	LERDCSANTTSCHIL CCCCCCCCCCEEEEE	27.82	12016211
134	N-linked_Glycosylation	LERDCSANTTSCHIL CCCCCCCCCCEEEEE	27.82	12016211
233	Phosphorylation	VYTNVCRYTNWIQKT EEEEHHHHCHHHHHH	10.17	22798277
234	Phosphorylation	YTNVCRYTNWIQKTI EEEHHHHCHHHHHHH	12.53	22798277

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLK6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLK6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLK6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYUA_HUMAN	SNCA	physical	12928483
CDYL_HUMAN	CDYL	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
EMC7_HUMAN	EMC7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.