ASZ1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASZ1_HUMAN
• UniProt AC: Q8WWH4
• Protein Name: Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1
• Gene Name: ASZ1 {ECO:0000312|HGNC:HGNC:1350}
• Organism: Homo sapiens (Human).
• Sequence Length: 475
• Subcellular Localization: Cytoplasm. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to pi-bodies, a subset of the nuage which contains primary piRNAs (By simil
• Protein Description: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity)..
• Protein Sequence: MAASALRGLPVAGGGESSESEDDGWEIGYLDRTSQKLKRLLPIEEKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNPLEGKLQQLTKEDTICKILTTDSDREKDHIFSSYTAFGDLEVFLHGLGLEHMTDLLKERDITLRHLLTMREDEFTKNGITSKDQQKILAALKELQVEEIQFGELSEETKLEISGDEFLNFLLKLNKQCGHLITAVQNVITELPVNSQKITLEWASPQNFTSVCEELVNNVEDLSEKVCKLKDLIQKLQNERENDPTHIQLREEVSTWNSRILKRTAITICGFGFLLFICKLTFQRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	PVAGGGESSESEDDG CCCCCCCCCCCCCCC	42.55	-
18	Phosphorylation	VAGGGESSESEDDGW CCCCCCCCCCCCCCC	40.62	-
20	Phosphorylation	GGGESSESEDDGWEI CCCCCCCCCCCCCCC	48.55	-
151	Phosphorylation	VACRRLMTPIMYAAR HHHHHHHCHHHHHHC	17.79	25690035
155	Phosphorylation	RLMTPIMYAARDGHT HHHCHHHHHHCCCCH	9.60	25690035
216	Acetylation	MLQTKDGKMPSEIAK HCCCCCCCCHHHHHH	58.74	7685219
372	Phosphorylation	KQCGHLITAVQNVIT HHHCHHHHHHHHHHH	27.43	24043423
379	Phosphorylation	TAVQNVITELPVNSQ HHHHHHHHHCCCCCE	27.47	24043423
385	Phosphorylation	ITELPVNSQKITLEW HHHCCCCCEEEEEEE	32.84	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASZ1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASZ1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASZ1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TS101_HUMAN	TSG101	physical	21880841

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.