RFIP4_HUMAN - dbPTM
RFIP4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RFIP4_HUMAN
UniProt AC Q86YS3
Protein Name Rab11 family-interacting protein 4
Gene Name RAB11FIP4
Organism Homo sapiens (Human).
Sequence Length 637
Subcellular Localization Endosome . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Recycling endosome membrane
Peripheral membrane protein. Cleavage furrow . Midbody . Cytoplasmic vesicle . Recruited to the cleavage
Protein Description Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6..
Protein Sequence MAGGAGWSGAPAALLRSVRRLREVFEVCGRDPDGFLRVERVAALGLRFGQGEEVEKLVKYLDPNDLGRINFKDFCRGVFAMKGCEELLKDVLSVESAGTLPCAPEIPDCVEQGSEVTGPTFADGELIPREPGFFPEDEEEAMTLAPPEGPQELYTDSPMESTQSLEGSVGSPAEKDGGLGGLFLPEDKSLVHTPSMTTSDLSTHSTTSLISNEEQFEDYGEGDDVDCAPSSPCPDDETRTNVYSDLGSSVSSSAGQTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKIILAILDHNPSILEIKH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3 (in isoform 2)Phosphorylation-25.7827050516
60PhosphorylationEVEKLVKYLDPNDLG
HHHHHHHHCCCCCCC		14.62-
143PhosphorylationEDEEEAMTLAPPEGP
CCHHHHHCCCCCCCC		27.1528348404
154PhosphorylationPEGPQELYTDSPMES
CCCCCCCCCCCCCCC		14.0328348404
155PhosphorylationEGPQELYTDSPMEST
CCCCCCCCCCCCCCC		42.5028348404
157PhosphorylationPQELYTDSPMESTQS
CCCCCCCCCCCCCCC		20.5328348404
161PhosphorylationYTDSPMESTQSLEGS
CCCCCCCCCCCCCCC		26.0428348404
162PhosphorylationTDSPMESTQSLEGSV
CCCCCCCCCCCCCCC		14.6328348404
164PhosphorylationSPMESTQSLEGSVGS
CCCCCCCCCCCCCCC		28.6028348404
168PhosphorylationSTQSLEGSVGSPAEK
CCCCCCCCCCCCCCC		17.5828348404
240PhosphorylationCPDDETRTNVYSDLG
CCCCCCCCCCCCCCC		36.1329978859
243PhosphorylationDETRTNVYSDLGSSV
CCCCCCCCCCCCCHH		9.8729978859
244PhosphorylationETRTNVYSDLGSSVS
CCCCCCCCCCCCHHC		23.2929978859
245UbiquitinationTRTNVYSDLGSSVSS
CCCCCCCCCCCHHCC		37.0421890473
248PhosphorylationNVYSDLGSSVSSSAG
CCCCCCCCHHCCCCC		34.5629978859
249PhosphorylationVYSDLGSSVSSSAGQ
CCCCCCCHHCCCCCC		24.9929978859
251PhosphorylationSDLGSSVSSSAGQTP
CCCCCHHCCCCCCCC		22.1128348404
252PhosphorylationDLGSSVSSSAGQTPR
CCCCHHCCCCCCCCC		23.2728348404
253PhosphorylationLGSSVSSSAGQTPRK
CCCHHCCCCCCCCCH		28.9824719451
257PhosphorylationVSSSAGQTPRKMRHV
HCCCCCCCCCHHCCC		24.9227251275
287UbiquitinationKINLLNDLEARLKNL
HHCHHHHHHHHHHHH		5.5832015554
304PhosphorylationNSPNRKISSTAFGRQ
CCCCCCCCHHHHHHH		25.3528348404
319PhosphorylationLMHSSNFSSSNGSTE
HHHCCCCCCCCCCHH		36.7928348404
320PhosphorylationMHSSNFSSSNGSTED
HHCCCCCCCCCCHHH		24.5628348404
321PhosphorylationHSSNFSSSNGSTEDL
HCCCCCCCCCCHHHH		43.9728348404
324PhosphorylationNFSSSNGSTEDLFRD
CCCCCCCCHHHHHHH		32.6428348404
325PhosphorylationFSSSNGSTEDLFRDS
CCCCCCCHHHHHHHH		34.6128348404
338UbiquitinationDSIDSCDNDITEKVS
HHHHHCCCCHHHHHH		47.0821890473
364UbiquitinationDSLTNGDLKSKLKQE
CCCCCCCHHHHHHHH		7.7621890473
376UbiquitinationKQENTQLVHRVHELE
HHHHHHHHHHHHHHH		1.6332015554
380UbiquitinationTQLVHRVHELEEMVK
HHHHHHHHHHHHHHC		33.6032015554
403 (in isoform 2)Ubiquitination-40.0221890473
403UbiquitinationALEEEARRHREAYGK
HHHHHHHHHHHHHHH		40.0221890473
406UbiquitinationEEARRHREAYGKLER
HHHHHHHHHHHHHHH		39.8732015554
445PhosphorylationTTVTRLKSQTEKLDE
HHHHHHHHHHHHHHH		47.10-
445UbiquitinationTTVTRLKSQTEKLDE
HHHHHHHHHHHHHHH		47.1032015554
469UbiquitinationEDTSLRLKDEMDLYK
HHHHHHHHHHHHHHH		45.2532015554
495UbiquitinationEFQKEREATQELIED
HHHHHHHHHHHHHHH		22.3232015554
505UbiquitinationELIEDLRKELEHLQM
HHHHHHHHHHHHHHH		74.1522817900
505 (in isoform 1)Ubiquitination-74.1521890473
525PhosphorylationERPGRGRSASSGLGE
CCCCCCCCCCCCCCH		35.0125850435
527PhosphorylationPGRGRSASSGLGEFN
CCCCCCCCCCCCHHH		26.6219664994
528PhosphorylationGRGRSASSGLGEFNA
CCCCCCCCCCCHHHH		37.4425850435
534UbiquitinationSSGLGEFNARAREVE
CCCCCHHHHHHHHHH		24.9832015554
547UbiquitinationVELEHEVKRLKQENY
HHHHHHHHHHHHHCC		49.3732015554
636UbiquitinationNPSILEIKH------
CCCHHHCCC------		33.6132015554
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RFIP4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RFIP4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RFIP4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RB11A_HUMANRAB11Aphysical
12470645
RFIP4_HUMANRAB11FIP4physical
12470645
RFIP3_HUMANRAB11FIP3physical
12470645
RFIP2_HUMANRAB11FIP2physical
12470645
RFIP5_HUMANRAB11FIP5physical
12470645
TS101_HUMANTSG101physical
22348143
ECM29_HUMANKIAA0368physical
20682791
RB11A_HUMANRAB11Aphysical
16148947
RFIP3_HUMANRAB11FIP3physical
28514442
TNIP2_HUMANTNIP2physical
28514442
CYTSB_HUMANSPECC1physical
28514442
FBX28_HUMANFBXO28physical
28514442
SBP1_HUMANSELENBP1physical
28514442
S10A3_HUMANS100A3physical
28514442
DUS14_HUMANDUSP14physical
28514442
LRC15_HUMANLRRC15physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RFIP4_HUMAN

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Related Literatures of Post-Translational Modification

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