GB_HHV8P - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GB_HHV8P
• UniProt AC: F5HB81
• Protein Name: Envelope glycoprotein B {ECO:0000255|HAMAP-Rule:MF_04032}
• Gene Name: gB {ECO:0000255|HAMAP-Rule:MF_04032}
• Organism: Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus).
• Sequence Length: 845
• Subcellular Localization: Virion membrane ; Single-pass type I membrane protein . Host cell membrane ; Single-pass type I membrane protein . Host endosome membrane ; Single-pass type I membrane protein . Host Golgi apparatus membrane ; Single-pass type I membrane protein . Du
• Protein Description: Envelope glycoprotein that forms spikes at the surface of the virion envelope. Participates in viral entry through an RGD motif that binds ITGAV-ITGB3. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress..
• Protein Sequence: MTPRSRLATLGTVILLVCFCAGAAHSRGDTFQTSSSPTPPGSSSKAPTKPGEEASGPKSVDFYQFRVCSASITGELFRFNLEQTCPDTKDKYHQEGILLVYKKNIVPHIFKVRRYRKIATSVTVYRGLTESAITNKYELPRPVPLYEISHMDSTYQCFSSMKVNVNGVENTFTDRDDVNTTVFLQPVEGLTDNIQRYFSQPVIYAEPGWFPGIYRVRTTVNCEIVDMIARSAEPYNYFVTSLGDTVEVSPFCYNESSCSTTPSNKNGLSVQVVLNHTVVTYSDRGTSPTPQNRIFVETGAYTLSWASESKTTAVCPLALWKTFPRSIQTTHEDSFHFVANEITATFTAPLTPVANFTDTYSCLTSDINTTLNASKAKLASTHVPNGTVQYFHTTGGLYLVWQPMSAINLTHAQGDSGNPTSSPPPSASPMTTSASRRKRRSASTAAAGGGGSTDNLSYTQLQFAYDKLRDGINQVLEELSRAWCREQVRDNLMWYELSKINPTSVMTAIYGRPVSAKFVGDAISVTECINVDQSSVNIHKSLRTNSKDVCYARPLVTFKFLNSSNLFTGQLGARNEIILTNNQVETCKDTCEHYFITRNETLVYKDYAYLRTINTTDISTLNTFIALNLSFIQNIDFKAIELYSSAEKRLASSVFDLETMFREYNYYTHRLAGLREDLDNTIDMNKERFVRDLSEIVADLGGIGKTVVNVASSVVTLCGSLVTGFINFIKHPLGGMLMIIIVIAIILIIFMLSRRTNTIAQAPVKMIYPDVDRRAPPSGGAPTREEIKNILLGMHQLQQEERQKADDLKKSTPSVFQRTANGLRQRLRGYKPLTQSLDISPETGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
179	N-linked_Glycosylation	FTDRDDVNTTVFLQP CCCCCCCCEEEEEEE		-
254	N-linked_Glycosylation	EVSPFCYNESSCSTT EECCCCCCCCCCCCC		-
275	N-linked_Glycosylation	LSVQVVLNHTVVTYS EEEEEEEECEEEECC		-
355	N-linked_Glycosylation	APLTPVANFTDTYSC CCCCCCCCEECCHHH		-
368	N-linked_Glycosylation	SCLTSDINTTLNASK HHHHCCHHHHCCHHH		-
372	N-linked_Glycosylation	SDINTTLNASKAKLA CCHHHHCCHHHCHHH		-
385	N-linked_Glycosylation	LASTHVPNGTVQYFH HHCCCCCCCEEEEEE		-
408	N-linked_Glycosylation	WQPMSAINLTHAQGD EEECCEEECCCCCCC		-
455	N-linked_Glycosylation	GGGGSTDNLSYTQLQ CCCCCCCCCCHHHHH		-
562	N-linked_Glycosylation	LVTFKFLNSSNLFTG EEEEEECCCCCCCCC		UniProtKB CARBOHYD
599	N-linked_Glycosylation	EHYFITRNETLVYKD CEEEEECCCEEEECC		UniProtKB CARBOHYD
614	N-linked_Glycosylation	YAYLRTINTTDISTL EEEEEECCCCCHHHH		-
628	N-linked_Glycosylation	LNTFIALNLSFIQNI HHHHHHHCCHHHHCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GB_HHV8P !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GB_HHV8P !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GB_HHV8P !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
B3GA3_HUMAN	B3GAT3	physical	25544563

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.