ARF1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARF1_MOUSE
• UniProt AC: P84078
• Protein Name: ADP-ribosylation factor 1
• Gene Name: Arf1
• Organism: Mus musculus (Mouse).
• Sequence Length: 181
• Subcellular Localization: Golgi apparatus. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Membrane ; Lipid-anchor .
• Protein Description: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD)..
• Protein Sequence: MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLRNQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGNIFANLF ------CCCHHHHHH	35.62	-
2	Myristoylation	------MGNIFANLF ------CCCHHHHHH	35.62	-
35	Phosphorylation	AGKTTILYKLKLGEI CCCEEEEEEEECCCE	15.49	-
36	Ubiquitination	GKTTILYKLKLGEIV CCEEEEEEEECCCEE	35.38	27667366
38	Ubiquitination	TTILYKLKLGEIVTT EEEEEEEECCCEEEE	50.74	-
59	Ubiquitination	NVETVEYKNISFTVW EEEEEEEEEEEEEEE	34.01	-
62	Phosphorylation	TVEYKNISFTVWDVG EEEEEEEEEEEEECC	25.02	22817900
73	Ubiquitination	WDVGGQDKIRPLWRH EECCCCCCCHHHHHH	32.50	-
127	Ubiquitination	VLLVFANKQDLPNAM HHHHEECCCCCCCCC	41.58	-
140	Phosphorylation	AMNAAEITDKLGLHS CCCHHHHHHHHCCHH	20.70	20415495
142	Acetylation	NAAEITDKLGLHSLR CHHHHHHHHCCHHCC	35.49	66698811
142	Ubiquitination	NAAEITDKLGLHSLR CHHHHHHHHCCHHCC	35.49	27667366
147	Phosphorylation	TDKLGLHSLRHRNWY HHHHCCHHCCCCCEE	31.94	22942356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARF1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARF1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARF1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ARF1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.