TMM9B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMM9B_HUMAN
• UniProt AC: Q9NQ34
• Protein Name: Transmembrane protein 9B
• Gene Name: TMEM9B
• Organism: Homo sapiens (Human).
• Sequence Length: 198
• Subcellular Localization: Lysosome membrane ; Single-pass membrane protein . Early endosome membrane ; Single-pass membrane protein .
• Protein Description: Enhances production of proinflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways..
• Protein Sequence: MATLWGGLLRLGSLLSLSCLALSVLLLAQLSDAAKNFEDVRCKCICPPYKENSGHIYNKNISQKDCDCLHVVEPMPVRGPDVEAYCLRCECKYEERSSVTIKVTIIIYLSILGLLLLYMVYLTLVEPILKRRLFGHAQLIQSDDDIGDHQPFANAHDVLARSRSRANVLNKVEYAQQRWKLQVQEQRKSVFDRHVVLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATLWGGLLR -----CCCHHHHHHH	23.03	20230923
60	N-linked_Glycosylation	SGHIYNKNISQKDCD CCCCCCCCCCHHCCC	35.19	UniProtKB CARBOHYD
97	Ubiquitination	ECKYEERSSVTIKVT EEECCCCCCCCHHHH	32.23	-
100	Phosphorylation	YEERSSVTIKVTIII CCCCCCCCHHHHHHH	19.61	29052541
104	Phosphorylation	SSVTIKVTIIIYLSI CCCCHHHHHHHHHHH	11.06	-
108	Phosphorylation	IKVTIIIYLSILGLL HHHHHHHHHHHHHHH	5.51	-
110	Phosphorylation	VTIIIYLSILGLLLL HHHHHHHHHHHHHHH	9.97	-
142	Phosphorylation	GHAQLIQSDDDIGDH CCCEEECCCCCCCCC	35.69	28857561
164	Phosphorylation	DVLARSRSRANVLNK HHHHHHHHHHHHHHH	36.67	23312004
171	Ubiquitination	SRANVLNKVEYAQQR HHHHHHHHHHHHHHH	32.08	21890473
171	Ubiquitination	SRANVLNKVEYAQQR HHHHHHHHHHHHHHH	32.08	21890473
174	Phosphorylation	NVLNKVEYAQQRWKL HHHHHHHHHHHHHHH	16.82	27642862
180	Ubiquitination	EYAQQRWKLQVQEQR HHHHHHHHHHHHHHH	31.09	-
189	Phosphorylation	QVQEQRKSVFDRHVV HHHHHHHHHHHHHHC	30.15	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMM9B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMM9B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMM9B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLCN3_HUMAN	CLCN3	physical	28514442
CLCN5_HUMAN	CLCN5	physical	28514442
DJC13_HUMAN	DNAJC13	physical	28514442
BIRC2_HUMAN	BIRC2	physical	28514442
ABCB9_HUMAN	ABCB9	physical	28514442
DYN3_HUMAN	DNM3	physical	28514442
DCAKD_HUMAN	DCAKD	physical	28514442
PDZD8_HUMAN	PDZD8	physical	28514442
FLVC1_HUMAN	FLVCR1	physical	28514442
ABCA3_HUMAN	ABCA3	physical	28514442
CA043_HUMAN	C1orf43	physical	28514442
DYN1_HUMAN	DNM1	physical	28514442
VANG2_HUMAN	VANGL2	physical	28514442
MYADM_HUMAN	MYADM	physical	28514442
F189B_HUMAN	FAM189B	physical	28514442
DYN2_HUMAN	DNM2	physical	28514442
RIF1_HUMAN	RIF1	physical	28514442
BIG2_HUMAN	ARFGEF2	physical	28514442
JPH1_HUMAN	JPH1	physical	28514442
TRAF2_HUMAN	TRAF2	physical	28514442
YIF1A_HUMAN	YIF1A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.