CLCN5_HUMAN - dbPTM
CLCN5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CLCN5_HUMAN
UniProt AC P51795
Protein Name H(+)/Cl(-) exchange transporter 5
Gene Name CLCN5
Organism Homo sapiens (Human).
Sequence Length 746
Subcellular Localization Golgi apparatus membrane
Multi-pass membrane protein . Endosome membrane
Multi-pass membrane protein . Cell membrane
Multi-pass membrane protein .
Protein Description Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function..
Protein Sequence MDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationEPIPGVGTYDDFNTI
CCCCCCCCCCCCCCH		22.7528270605
14PhosphorylationPIPGVGTYDDFNTID
CCCCCCCCCCCCCHH		13.9528270605
19PhosphorylationGTYDDFNTIDWVREK
CCCCCCCCHHHHHHH		21.9528270605
57UbiquitinationSVSDAFSGWLLMLLI
HHHHHHHHHHHHHHH		16.76-
57 (in isoform 2)Ubiquitination-16.76-
58PhosphorylationVSDAFSGWLLMLLIG
HHHHHHHHHHHHHHH		5.78-
58 (in isoform 2)Phosphorylation-5.7825159151
59 (in isoform 2)Phosphorylation-1.9928634120
66PhosphorylationLLMLLIGLLSGSLAG
HHHHHHHHHHHHHHH		2.4627251275
66 (in isoform 2)Phosphorylation-2.4627251275
67 (in isoform 2)Phosphorylation-4.6127251275
291PhosphorylationAALVAAFTLRSINPF
HHHHHHHHHHCCCCC		19.2824719451
301PhosphorylationSINPFGNSRLVLFYV
CCCCCCCEEEEEEEE		27.63-
425PhosphorylationRPAGVGVYSAMWQLA
CCCCHHHHHHHHHHH		5.7022817900
518PhosphorylationLGGVTRMTVSLVVIM
HCCHHHHHHHEEEEE		12.0324043423
520PhosphorylationGVTRMTVSLVVIMFE
CHHHHHHHEEEEEHH		13.2824043423
529PhosphorylationVVIMFELTGGLEYIV
EEEEHHHCCCHHHHH		23.2324043423
534PhosphorylationELTGGLEYIVPLMAA
HHCCCHHHHHHHHHH		16.5624043423
544PhosphorylationPLMAAAMTSKWVADA
HHHHHHHCHHHHHHH		23.5624043423
545PhosphorylationLMAAAMTSKWVADAL
HHHHHHCHHHHHHHH		16.0724043423
579UbiquitinationAKEEFAHKTLAMDVM
CHHHHHHHHHHHHHC		41.6321890473
580PhosphorylationKEEFAHKTLAMDVMK
HHHHHHHHHHHHHCC		15.1924719451
599UbiquitinationDPLLTVLTQDSMTVE
CCCEEEEECCCCCHH		26.452189047
649UbiquitinationISIENARKKQDGVVS
EEEHHHHHHCCCCEE		52.99-
649 (in isoform 2)Ubiquitination-52.99-
649UbiquitinationISIENARKKQDGVVS
EEEHHHHHHCCCCEE		52.9921890473
649UbiquitinationISIENARKKQDGVVS
EEEHHHHHHCCCCEE		52.9921890473
686PhosphorylationLRNILDLSPFTVTDL
CCCCCCCCCCCCCCC		20.0322468782
694PhosphorylationPFTVTDLTPMEIVVD
CCCCCCCCHHHHHHH		24.3322468782
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseNEDD4LQ96PU5
PMID:15489223
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CLCN5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CLCN5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CLCN5_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CLCN5_HUMAN

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Related Literatures of Post-Translational Modification

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