TET2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TET2_MOUSE
• UniProt AC: Q4JK59
• Protein Name: Methylcytosine dioxygenase TET2
• Gene Name: Tet2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1912
• Protein Description: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT..
• Protein Sequence: MEQDRTTHAEGTRLSPFLIAPPSPISHTEPLAVKLQNGSPLAERPHPEVNGDTKWQSSQSCYGISHMKGSQSSHESPHEDRGYSRCLQNGGIKRTVSEPSLSGLHPNKILKLDQKAKGESNIFEESQERNHGKSSRQPNVSGLSDNGEPVTSTTQESSGADAFPTRNYNGVEIQVLNEQEGEKGRSVTLLKNKIVLMPNGATVSAHSEENTRGELLEKTQCYPDCVSIAVQSTASHVNTPSSQAAIELSHEIPQPSLTSAQINFSQTSSLQLPPEPAAMVTKACDADNASKPAIVPGTCPFQKAEHQQKSALDIGPSRAENKTIQGSMELFAEEYYPSSDRNLQASHGSSEQYSKQKETNGAYFRQSSKFPKDSISPTTVTPPSQSLLAPRLVLQPPLEGKGALNDVALEEHHDYPNRSNRTLLREGKIDHQPKTSSSQSLNPSVHTPNPPLMLPEQHQNDCGSPSPEKSRKMSEYLMYYLPNHGHSGGLQEHSQYLMGHREQEIPKDANGKQTQGSVQAAPGWIELKAPNLHEALHQTKRKDISLHSVLHSQTGPVNQMSSKQSTGNVNMPGGFQRLPYLQKTAQPEQKAQMYQVQVNQGPSPGMGDQHLQFQKALYQECIPRTDPSSEAHPQAPSVPQYHFQQRVNPSSDKHLSQQATETQRLSGFLQHTPQTQASQTPASQNSNFPQICQQQQQQQLQRKNKEQMPQTFSHLQGSNDKQREGSCFGQIKVEESFCVGNQYSKSSNFQTHNNTQGGLEQVQNINKNFPYSKILTPNSSNLQILPSNDTHPACEREQALHPVGSKTSNLQNMQYFPNNVTPNQDVHRCFQEQAQKPQQASSLQGLKDRSQGESPAPPAEAAQQRYLVHNEAKALPVPEQGGSQTQTPPQKDTQKHAALRWLLLQKQEQQQTQQSQPGHNQMLRPIKTEPVSKPSSYRYPLSPPQENMSSRIKQEISSPSRDNGQPKSIIETMEQHLKQFQLKSLCDYKALTLKSQKHVKVPTDIQAAESENHARAAEPQATKSTDCSVLDDVSESDTPGEQSQNGKCEGCNPDKDEAPYYTHLGAGPDVAAIRTLMEERYGEKGKAIRIEKVIYTGKEGKSSQGCPIAKWVYRRSSEEEKLLCLVRVRPNHTCETAVMVIAIMLWDGIPKLLASELYSELTDILGKCGICTNRRCSQNETRNCCCQGENPETCGASFSFGCSWSMYYNGCKFARSKKPRKFRLHGAEPKEEERLGSHLQNLATVIAPIYKKLAPDAYNNQVEFEHQAPDCCLGLKEGRPFSGVTACLDFSAHSHRDQQNMPNGSTVVVTLNREDNREVGAKPEDEQFHVLPMYIIAPEDEFGSTEGQEKKIRMGSIEVLQSFRRRRVIRIGELPKSCKKKAEPKKAKTKKAARKRSSLENCSSRTEKGKSSSHTKLMENASHMKQMTAQPQLSGPVIRQPPTLQRHLQQGQRPQQPQPPQPQPQTTPQPQPQPQHIMPGNSQSVGSHCSGSTSVYTRQPTPHSPYPSSAHTSDIYGDTNHVNFYPTSSHASGSYLNPSNYMNPYLGLLNQNNQYAPFPYNGSVPVDNGSPFLGSYSPQAQSRDLHRYPNQDHLTNQNLPPIHTLHQQTFGDSPSKYLSYGNQNMQRDAFTTNSTLKPNVHHLATFSPYPTPKMDSHFMGAASRSPYSHPHTDYKTSEHHLPSHTIYSYTAAASGSSSSHAFHNKENDNIANGLSRVLPGFNHDRTASAQELLYSLTGSSQEKQPEVSGQDAAAVQEIEYWSDSEHNFQDPCIGGVAIAPTHGSILIECAKCEVHATTKVNDPDRNHPTRISLVLYRHKNLFLPKHCLALWEAKMAEKARKEEECGKNGSDHVSQKNHGKQEKREPTGPQEPSYLRFIQSLAENTGSVTTDSTVTTSPYAFTQVTGPYNTFV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MEQDRTTHAEGTR --CCCCCCCCCCCCC	31.09	26643407
7	Phosphorylation	-MEQDRTTHAEGTRL -CCCCCCCCCCCCCC	21.71	26643407
12	Phosphorylation	RTTHAEGTRLSPFLI CCCCCCCCCCCCEEE	21.68	26643407
15	O-linked_Glycosylation	HAEGTRLSPFLIAPP CCCCCCCCCEEECCC	15.43	25568311
15	Phosphorylation	HAEGTRLSPFLIAPP CCCCCCCCCEEECCC	15.43	25266776
23	O-linked_Glycosylation	PFLIAPPSPISHTEP CEEECCCCCCCCCCC	33.53	25568311
23	Phosphorylation	PFLIAPPSPISHTEP CEEECCCCCCCCCCC	33.53	26824392
26	O-linked_Glycosylation	IAPPSPISHTEPLAV ECCCCCCCCCCCCEE	27.95	25568311
26	Phosphorylation	IAPPSPISHTEPLAV ECCCCCCCCCCCCEE	27.95	25159016
28	O-linked_Glycosylation	PPSPISHTEPLAVKL CCCCCCCCCCCEEEC	32.29	25568311
28	Phosphorylation	PPSPISHTEPLAVKL CCCCCCCCCCCEEEC	32.29	25159016
39	Phosphorylation	AVKLQNGSPLAERPH EEECCCCCCCCCCCC	25.04	26643407
57	O-linked_Glycosylation	NGDTKWQSSQSCYGI CCCCCCCCCCCEECH	29.27	25568311
58	O-linked_Glycosylation	GDTKWQSSQSCYGIS CCCCCCCCCCEECHH	15.83	25568311
70	Phosphorylation	GISHMKGSQSSHESP CHHHCCCCCCCCCCC	22.75	30635358
72	Phosphorylation	SHMKGSQSSHESPHE HHCCCCCCCCCCCCC	35.05	30635358
73	Phosphorylation	HMKGSQSSHESPHED HCCCCCCCCCCCCCC	24.52	30635358
76	Phosphorylation	GSQSSHESPHEDRGY CCCCCCCCCCCCCCH	26.57	30635358
83	Phosphorylation	SPHEDRGYSRCLQNG CCCCCCCHHHHHHCC	8.20	30635358
84	Phosphorylation	PHEDRGYSRCLQNGG CCCCCCHHHHHHCCC	21.24	30635358
95	O-linked_Glycosylation	QNGGIKRTVSEPSLS HCCCCCCCCCCCCCC	24.31	25568311
95	Phosphorylation	QNGGIKRTVSEPSLS HCCCCCCCCCCCCCC	24.31	26745281
97	O-linked_Glycosylation	GGIKRTVSEPSLSGL CCCCCCCCCCCCCCC	43.08	6696001
97	Phosphorylation	GGIKRTVSEPSLSGL CCCCCCCCCCCCCCC	43.08	29176673
100	Phosphorylation	KRTVSEPSLSGLHPN CCCCCCCCCCCCCHH	30.99	26643407
102	Phosphorylation	TVSEPSLSGLHPNKI CCCCCCCCCCCHHHE	43.58	26745281
134	O-linked_Glycosylation	QERNHGKSSRQPNVS HHHHCCCCCCCCCCC	35.03	25568311
135	O-linked_Glycosylation	ERNHGKSSRQPNVSG HHHCCCCCCCCCCCC	38.12	25568311
165	O-linked_Glycosylation	SGADAFPTRNYNGVE CCCCCCCCCCCCCEE	25.70	25568311
202	O-linked_Glycosylation	VLMPNGATVSAHSEE EECCCCCEEECCCCC	19.18	25568311
204	O-linked_Glycosylation	MPNGATVSAHSEENT CCCCCEEECCCCCCC	18.86	25568311
211	O-linked_Glycosylation	SAHSEENTRGELLEK ECCCCCCCCHHHHHH	43.24	25568311
290	O-linked_Glycosylation	ACDADNASKPAIVPG CCCCCCCCCCCCCCC	45.48	105050807
317	O-linked_Glycosylation	SALDIGPSRAENKTI CCCCCCCCHHCCCCC	38.62	72254397
346	O-linked_Glycosylation	SDRNLQASHGSSEQY CCCCCCCCCCCHHHH	18.54	25568311
349	O-linked_Glycosylation	NLQASHGSSEQYSKQ CCCCCCCCHHHHHHH	25.86	25568311
350	O-linked_Glycosylation	LQASHGSSEQYSKQK CCCCCCCHHHHHHHH	33.06	25568311
374	O-linked_Glycosylation	SSKFPKDSISPTTVT CCCCCCCCCCCCCCC	30.96	63812885
374	Phosphorylation	SSKFPKDSISPTTVT CCCCCCCCCCCCCCC	30.96	21149613
376	O-linked_Glycosylation	KFPKDSISPTTVTPP CCCCCCCCCCCCCCC	21.83	25568311
376	Phosphorylation	KFPKDSISPTTVTPP CCCCCCCCCCCCCCC	21.83	21149613
378	O-linked_Glycosylation	PKDSISPTTVTPPSQ CCCCCCCCCCCCCCH	27.40	25568311
378	Phosphorylation	PKDSISPTTVTPPSQ CCCCCCCCCCCCCCH	27.40	21149613
379	O-linked_Glycosylation	KDSISPTTVTPPSQS CCCCCCCCCCCCCHH	26.26	25568311
379	Phosphorylation	KDSISPTTVTPPSQS CCCCCCCCCCCCCHH	26.26	21149613
381	O-linked_Glycosylation	SISPTTVTPPSQSLL CCCCCCCCCCCHHCC	27.65	25568311
381	Phosphorylation	SISPTTVTPPSQSLL CCCCCCCCCCCHHCC	27.65	21149613
384	O-linked_Glycosylation	PTTVTPPSQSLLAPR CCCCCCCCHHCCCCE	33.34	25568311
384	Phosphorylation	PTTVTPPSQSLLAPR CCCCCCCCHHCCCCE	33.34	21149613
386	O-linked_Glycosylation	TVTPPSQSLLAPRLV CCCCCCHHCCCCEEE	29.68	25568311
386	Phosphorylation	TVTPPSQSLLAPRLV CCCCCCHHCCCCEEE	29.68	21149613
464	Phosphorylation	QHQNDCGSPSPEKSR HHCCCCCCCCHHHHH	28.65	-
466	Phosphorylation	QNDCGSPSPEKSRKM CCCCCCCCHHHHHHH	47.60	-
514	O-linked_Glycosylation	KDANGKQTQGSVQAA CCCCCCCCCCCCEEC	38.08	77070251
517	O-linked_Glycosylation	NGKQTQGSVQAAPGW CCCCCCCCCEECCCE	10.96	25568311
545	O-linked_Glycosylation	QTKRKDISLHSVLHS HHHCCCCCHHHHHHC	30.11	77070267
548	O-linked_Glycosylation	RKDISLHSVLHSQTG CCCCCHHHHHHCCCC	31.50	25568311
552	O-linked_Glycosylation	SLHSVLHSQTGPVNQ CHHHHHHCCCCCCHH	25.85	77070261
554	O-linked_Glycosylation	HSVLHSQTGPVNQMS HHHHHCCCCCCHHCC	46.60	25568311
561	O-linked_Glycosylation	TGPVNQMSSKQSTGN CCCCHHCCCCCCCCC	25.31	77070273
562	O-linked_Glycosylation	GPVNQMSSKQSTGNV CCCHHCCCCCCCCCC	29.40	77070265
565	O-linked_Glycosylation	NQMSSKQSTGNVNMP HHCCCCCCCCCCCCC	41.86	77070271
603	Phosphorylation	VQVNQGPSPGMGDQH EECCCCCCCCCCHHH	40.69	-
625	O-linked_Glycosylation	YQECIPRTDPSSEAH HHHHCCCCCCCCCCC	47.08	77070269
711	O-linked_Glycosylation	NKEQMPQTFSHLQGS CHHHCCHHHHHHCCC	22.64	25568311
713	O-linked_Glycosylation	EQMPQTFSHLQGSND HHCCHHHHHHCCCCC	27.03	25568311
736	O-linked_Glycosylation	GQIKVEESFCVGNQY CEEEEEEEEECCCCC	15.50	25568311
744	O-linked_Glycosylation	FCVGNQYSKSSNFQT EECCCCCCCCCCCCC	19.12	77070263
776	O-linked_Glycosylation	FPYSKILTPNSSNLQ CCCHHCCCCCCCCCE	24.73	77070277
779	O-linked_Glycosylation	SKILTPNSSNLQILP HHCCCCCCCCCEECC	23.08	25568311
805	O-linked_Glycosylation	QALHPVGSKTSNLQN HHHCCCCCCCCCCCC	32.75	25568311
807	O-linked_Glycosylation	LHPVGSKTSNLQNMQ HCCCCCCCCCCCCCC	25.25	25568311
808	O-linked_Glycosylation	HPVGSKTSNLQNMQY CCCCCCCCCCCCCCC	39.00	25568311
850	O-linked_Glycosylation	LQGLKDRSQGESPAP HHCCHHHHCCCCCCC	53.31	25568311
854	Phosphorylation	KDRSQGESPAPPAEA HHHHCCCCCCCHHHH	32.94	30635358
883	Phosphorylation	PVPEQGGSQTQTPPQ CCCCCCCCCCCCCCC	36.56	22006019
887	Phosphorylation	QGGSQTQTPPQKDTQ CCCCCCCCCCCHHHH	40.08	-
912	O-linked_Glycosylation	QKQEQQQTQQSQPGH HHHHHHHHHHCCCCC	25.00	105050811
942	Phosphorylation	SSYRYPLSPPQENMS CCCCCCCCCCCCCHH	29.99	22942356
949	Phosphorylation	SPPQENMSSRIKQEI CCCCCCHHHHHHHHH	28.22	-
957	Phosphorylation	SRIKQEISSPSRDNG HHHHHHHCCCCCCCC	35.13	25367039
958	Phosphorylation	RIKQEISSPSRDNGQ HHHHHHCCCCCCCCC	32.34	29895711
1028	Phosphorylation	ATKSTDCSVLDDVSE CCCCCCCCCCCCCCC	28.64	22006019
1034	Phosphorylation	CSVLDDVSESDTPGE CCCCCCCCCCCCCCC	38.08	22006019
1036	Phosphorylation	VLDDVSESDTPGEQS CCCCCCCCCCCCCCC	39.00	-
1177	Phosphorylation	ICTNRRCSQNETRNC CCCCCCCCCCCCCCC	33.94	22871156
1181	Phosphorylation	RRCSQNETRNCCCQG CCCCCCCCCCCCCCC	34.43	22871156
1362	Phosphorylation	GSIEVLQSFRRRRVI CHHHHHHHHHHCCEE	19.29	23140645
1428	O-linked_Glycosylation	ASHMKQMTAQPQLSG HHHHHHHCCCCCCCC	21.46	25568311
1434	O-linked_Glycosylation	MTAQPQLSGPVIRQP HCCCCCCCCCCCCCC	35.48	72255793
1595	O-linked_Glycosylation	YPNQDHLTNQNLPPI CCCCCCCCCCCCCCC	31.19	25568311
1604	O-linked_Glycosylation	QNLPPIHTLHQQTFG CCCCCCCCCCCCCCC	27.01	77070283
1613	O-linked_Glycosylation	HQQTFGDSPSKYLSY CCCCCCCCHHHCHHC	31.30	25568311
1613	Phosphorylation	HQQTFGDSPSKYLSY CCCCCCCCHHHCHHC	31.30	-
1615	O-linked_Glycosylation	QTFGDSPSKYLSYGN CCCCCCHHHCHHCCC	37.57	25568311
1619	O-linked_Glycosylation	DSPSKYLSYGNQNMQ CCHHHCHHCCCCCCC	28.09	105050805
1631	O-linked_Glycosylation	NMQRDAFTTNSTLKP CCCCCCCCCCCCCCC	27.13	77070281
1631	Phosphorylation	NMQRDAFTTNSTLKP CCCCCCCCCCCCCCC	27.13	29899451
1632	Phosphorylation	MQRDAFTTNSTLKPN CCCCCCCCCCCCCCC	22.25	29899451
1645	O-linked_Glycosylation	PNVHHLATFSPYPTP CCEEEEEECCCCCCC	30.88	25568311
1647	O-linked_Glycosylation	VHHLATFSPYPTPKM EEEEEECCCCCCCCC	21.12	25568311
1651	O-linked_Glycosylation	ATFSPYPTPKMDSHF EECCCCCCCCCCCCC	29.69	25568311
1663	O-linked_Glycosylation	SHFMGAASRSPYSHP CCCCCCCCCCCCCCC	32.53	77070259
1672	O-linked_Glycosylation	SPYSHPHTDYKTSEH CCCCCCCCCCCCCCC	45.54	25568311
1694	O-linked_Glycosylation	YSYTAAASGSSSSHA EEEEECCCCCCCCCC	34.19	25568311
1696	O-linked_Glycosylation	YTAAASGSSSSHAFH EEECCCCCCCCCCCC	25.26	25568311
1697	O-linked_Glycosylation	TAAASGSSSSHAFHN EECCCCCCCCCCCCC	39.11	25568311
1698	O-linked_Glycosylation	AAASGSSSSHAFHNK ECCCCCCCCCCCCCC	28.04	25568311
1735	O-linked_Glycosylation	SAQELLYSLTGSSQE CHHHHHHHHHCCCCC	21.30	25568311
1740	Phosphorylation	LYSLTGSSQEKQPEV HHHHHCCCCCCCCCC	43.64	-
1867	Phosphorylation	KQEKREPTGPQEPSY CCCCCCCCCCCCCHH	57.66	30387612
1873	Phosphorylation	PTGPQEPSYLRFIQS CCCCCCCHHHHHHHH	35.73	30387612
1874	Phosphorylation	TGPQEPSYLRFIQSL CCCCCCHHHHHHHHH	16.77	30387612

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
97	S	Phosphorylation	Kinase	AMPKA1	Q13131	PSP
97	S	Phosphorylation	Kinase	AMPKA1	Q5EG47	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TET2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TET2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAP30_MOUSE	Sap30	physical	21490601
SDS3_MOUSE	Suds3	physical	21490601
SP130_MOUSE	Sap130	physical	21490601
HDAC2_MOUSE	Hdac2	physical	21490601
RBBP7_MOUSE	Rbbp7	physical	21490601
HDAC1_MOUSE	Hdac1	physical	21490601
ARI4B_MOUSE	Arid4b	physical	21490601
SIN3A_MOUSE	Sin3a	physical	21490601

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.