dbPTM

SDS3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SDS3_MOUSE
UniProt AC	Q8BR65
Protein Name	Sin3 histone deacetylase corepressor complex component SDS3
Gene Name	Suds3
Organism	Mus musculus (Mouse).
Sequence Length	328
Subcellular Localization	Nucleus .
Protein Description	Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity)..
Protein Sequence	MSAAGLLAPAPAPAAAPAAPEYYPEDEEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYRERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKRPASPSSPEHLPATPAESPAQRFEARIEDGKLYYDKRWYHKSQAIYLESKDNQKLSCVISSVGANEIWVRKTSDSTKMRIYVGQLQRGLFVIRRRSAA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSAAGLLAP ------CCCCCCCCC	27.16	-
23	Phosphorylation	APAAPEYYPEDEEEL CCCCCCCCCCCHHHH	9.85	25293948
32	Phosphorylation	EDEEELESAEDDERS CCHHHHHCCCCCHHH	49.97	30352176
39	Phosphorylation	SAEDDERSCRGRESD CCCCCHHHHCCCCCC	13.20	22006019
45	Phosphorylation	RSCRGRESDEDTEDA HHHCCCCCCCCCCCC	44.96	25521595
49	Phosphorylation	GRESDEDTEDASETD CCCCCCCCCCCCCCC	33.44	25521595
53	Phosphorylation	DEDTEDASETDLAKH CCCCCCCCCCCHHHC	54.04	25521595
55	Phosphorylation	DTEDASETDLAKHDE CCCCCCCCCHHHCCH	33.54	25521595
65	Phosphorylation	AKHDEEDYVEMKEQM HHCCHHHHHHHHHHH	11.11	29899451
128	Phosphorylation	TEQVERNYIKEKKAA HHHHHHHHHHHHHHH	21.42	23567750
228	Phosphorylation	RTLNKLKSPKRPASP HHHHHCCCCCCCCCC	46.20	22398430
234	Phosphorylation	KSPKRPASPSSPEHL CCCCCCCCCCCCCCC	28.18	27087446
236	Phosphorylation	PKRPASPSSPEHLPA CCCCCCCCCCCCCCC	56.90	27087446
237	Phosphorylation	KRPASPSSPEHLPAT CCCCCCCCCCCCCCC	37.38	27087446
244	Phosphorylation	SPEHLPATPAESPAQ CCCCCCCCCCCCHHH	22.53	21082442
248	Phosphorylation	LPATPAESPAQRFEA CCCCCCCCHHHHHEE	27.86	20469934

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
228	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
228	S	Phosphorylation	Kinase	CDK5	P49615	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
63	K	Acetylation	-
'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation.
63	K	ubiquitylation	-
'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SDS3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CD5R1_HUMAN	CDK5R1	physical	15489224
SIN3A_MOUSE	Sin3a	physical	15489224
SDS3_MOUSE	Suds3	physical	15489224
SIN3B_MOUSE	Sin3b	physical	15489224

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SDS3_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45; THR-49 AND THR-244,AND MASS SPECTROMETRY.	17242355 [Abstract]