SIN3B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIN3B_MOUSE
• UniProt AC: Q62141
• Protein Name: Paired amphipathic helix protein Sin3b
• Gene Name: Sin3b
• Organism: Mus musculus (Mouse).
• Sequence Length: 1098
• Subcellular Localization: Nucleus .
• Protein Description: Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. [PubMed: 22476904]
• Protein Sequence: MAHAGSGGSAGRGFGGSRWGRSGSGGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLFHEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLSSQDNSHSHGDCGEDFKQMSYKEDRGQVPLESDSVEFNNAISYVNKIKTRFLDHPEIYRSFLEILHTYQKEQLHTKGRPFRGMSEEEVFTEVANLFRGQEDLLSEFGQFLPEAKRSLFTGNGSCEMNSGQKNEEKSLEHNKKRSRPSLLRPVSAPAKKKMKLRGTKDLSIAAVGKYGTLQEFSFFDKVRRVLKSQEVYENFLRCIALFNQELVSGSELLQLVSPFLGKFPELFAQFKSFLGVKELSFAPPMSDRSGDGISREIDYASCKRIGSSYRALPKTYQQPKCSGRTAICKEVLNDTWVSFPSWSEDSTFVSSKKTPYEEQLHRCEDERFELDVVLETNLATIRVLESVQKKLSRMAPEDQEKLRLDDCLGGTSEVIQRRAIHRIYGDKAPEVIESLKRNPATAVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQAVNFKQNDTKALRSKSLLNEIESVYDEHQEQHSEGRSAPSSEPHLIFVYEDRQILEDAAALISYYVKRQPAIQKEDQGTIRQLLHRFLPSLFFSQQCPGTSDDSADERDRDRDSAEPERRRPTDEKPPADASPEPPKVLDDVYSLFFANNNWYFFLRLHQTLCARLLKIYRQAQKQLLEHRREQEREQLLCEGRREKAADPAMELRLKQPSEVELEEYYPAFLDMVRSLLEGSIDPTQYEDTLREMFTIHAYIGFTMDKLVQNIARQLHHLVSDDVCLKVVELYLNEQQRGAAGGNLSSRCVRAARETSYQWKAERCMADENCFKVMFLQRRGQVIMTIELLDTEEAQTEDPVEVQHLARYVEQYVGSEGASSSSTEGFLLKPVFLQRNLKKFRRWQCEQVRAMRGEAKSSWKRLMGVESACDVDCRFRLGTHKMVFIVNSEDYMYRRGTLCRAKQVQPLVLLRHHRHFEEWHGRWLEDNVTVAAAGLVQDWLMGEEEEDMVPCKTLCETAHVHGLPVTRYRVQYSRRPASP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Methylation	GSGGSAGRGFGGSRW CCCCCCCCCCCCCCC	36.66	58859559
22	Phosphorylation	GGSRWGRSGSGGHEK CCCCCCCCCCCCCCC	33.11	25338131
24	Phosphorylation	SRWGRSGSGGHEKLP CCCCCCCCCCCCCCC	42.73	25338131
115	Phosphorylation	NGKLNIQSPLSSQDN CCCCCCCCCCCCCCC	24.82	25619855
118	Phosphorylation	LNIQSPLSSQDNSHS CCCCCCCCCCCCCCC	29.36	25619855
119	Phosphorylation	NIQSPLSSQDNSHSH CCCCCCCCCCCCCCC	49.59	25619855
123	Phosphorylation	PLSSQDNSHSHGDCG CCCCCCCCCCCCCCC	34.36	25619855
125	Phosphorylation	SSQDNSHSHGDCGED CCCCCCCCCCCCCHH	29.05	25619855
231	Ubiquitination	GQFLPEAKRSLFTGN HHHCHHHHHHHHCCC	40.64	-
264	Phosphorylation	NKKRSRPSLLRPVSA HHHCCCCHHCCCCCC	38.64	23335269
270	Phosphorylation	PSLLRPVSAPAKKKM CHHCCCCCCCCHHHC	31.08	-
599	Phosphorylation	DEHQEQHSEGRSAPS HHHHHHHCCCCCCCC	41.25	25338131
666	Phosphorylation	FSQQCPGTSDDSADE HCCCCCCCCCCCCCH	17.71	25619855
667	Phosphorylation	SQQCPGTSDDSADER CCCCCCCCCCCCCHH	45.39	25619855
670	Phosphorylation	CPGTSDDSADERDRD CCCCCCCCCCHHHHC	42.48	7889570
680	Phosphorylation	ERDRDRDSAEPERRR HHHHCCCCCCCHHCC	35.11	28066266
698	Phosphorylation	EKPPADASPEPPKVL CCCCCCCCCCCCCHH	30.28	26824392
940	Phosphorylation	GSEGASSSSTEGFLL CCCCCCCCCCCCCCC	38.49	19060867
941	Phosphorylation	SEGASSSSTEGFLLK CCCCCCCCCCCCCCC	32.21	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Rnf220	Q6PDX6	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIN3B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIN3B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IFRD1_HUMAN	IFRD1	physical	12198164
REST_HUMAN	REST	physical	10570134
SIN3A_MOUSE	Sin3a	physical	16103876
HDAC1_MOUSE	Hdac1	physical	16103876
MYT1_MOUSE	Myt1	physical	15935060
HDAC1_MOUSE	Hdac1	physical	10409740
PHF12_MOUSE	Phf12	physical	21041482
MO4L1_MOUSE	Morf4l1	physical	21041482
HDAC1_MOUSE	Hdac1	physical	21041482

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.