MYT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYT1_MOUSE
• UniProt AC: Q8CFC2
• Protein Name: Myelin transcription factor 1
• Gene Name: Myt1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1127
• Subcellular Localization: Nucleus.
• Protein Description: Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity)..
• Protein Sequence: MSSESDDKRARTRSKTLRGPPETTGADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKRKLEDAETEHLVSKRKSHPLRLALDEGYRMDSDGSEDAEVKDVSVSDESEGPLEEAEAEMSGQEEIHHPQTAEGKSLIKPHFDSNPTSSPSGFSKSSYSSYQGIIATSLLNLGQIAEEALVKEDSVSVAKLSPTVVHQLQDEAAMGVNSDEGEKDLFIQPEDVEEVIEVTSERSQEPCPQSLKDMVSEESSKQKGVLGHEEEGEEEEEDEEEEDEEEEEEGEEGEEEEEEEEEEEEEEDEEEEEEEEEAAPNVIFGEDTSHTSVQKASPEFRGPELSSPKPEYSVIVEVRSDDDKDEDSRSQKSAVTDESEMYDMMTRGNLGLLEQAIALKAEQVRAVCESGCPPAEQGHLGPGEPGKMAKPLDVVRKSCYSKDPSRVEKREIKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEILAMHENVLKCPTPGCTGQGHVNSNRNTHRSLSGCPIAAAEKLAKSHEKQQLQTGDPPKNNSNSDRILRPMCFVKQLEVPPYGSYRPNVAPATPRANLAKELEKFSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFQCFDYSHDAEAAHMAATAILNLSTRCWEMPENLSTKPQDLPSKAVDIEVDENGTLDLSMHKHRKRENTFPSSSSCSSSPGVKSPDVSQRQSSTSAPSSSMTSPQSSQASRQDEWDRPLDYTKPSRLREEEPEESEPAAHSFASSEADDQEVSEENFEERKYPGEVTLTNFKLKFLSKDIKKELLTCPTPGCDGSGHITGNYASHRSLSGCPLADKSLRNLMAAHSADLKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGLKVAPTKDDKEDPELMKCPVPGCVGLGHISGKYASHRSASGCPLAARRQKEGALNGSSFSWKSLKNEGPTCPTPGCDGSGHANGSFLTHRSLSGCPRATFAGKKGKLSGDEILSPKFKTSDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALIQSLANIRLPHMEPICEQNFDAYVNTLTDMYSNQDCYQNPENKGLLETIKQAVRGIQV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Phosphorylation	GKYSRHRSLQSCPLA CCCCCCCCCCCCCCC	25.33	28066266
72	Phosphorylation	AETEHLVSKRKSHPL HHHHHHHHHCCCCCH	32.86	28059163
91	Phosphorylation	DEGYRMDSDGSEDAE CCCCCCCCCCCCCCC	34.23	28066266
94	Phosphorylation	YRMDSDGSEDAEVKD CCCCCCCCCCCCEEE	36.98	28066266
105	Phosphorylation	EVKDVSVSDESEGPL CEEEEECCCCCCCCH	28.31	27841257
108	Phosphorylation	DVSVSDESEGPLEEA EEECCCCCCCCHHHH	53.49	27841257
147	Phosphorylation	HFDSNPTSSPSGFSK CCCCCCCCCCCCCCC	41.32	27841257
148	Phosphorylation	FDSNPTSSPSGFSKS CCCCCCCCCCCCCCC	26.09	27841257
184	Phosphorylation	EALVKEDSVSVAKLS HHHHCCCCCCHHHCC	19.86	27841257
191	Phosphorylation	SVSVAKLSPTVVHQL CCCHHHCCHHHHHHH	20.16	28066266
193	Phosphorylation	SVAKLSPTVVHQLQD CHHHCCHHHHHHHHH	31.61	28066266
208	Phosphorylation	EAAMGVNSDEGEKDL HHCCCCCCCCCCCCC	34.33	27841257
233	Phosphorylation	IEVTSERSQEPCPQS HHHCCCCCCCCCCHH	34.54	28066266
327	Phosphorylation	HTSVQKASPEFRGPE CCCCHHCCCCCCCCC	31.81	27841257
336	Phosphorylation	EFRGPELSSPKPEYS CCCCCCCCCCCCCEE	42.82	27841257
337	Phosphorylation	FRGPELSSPKPEYSV CCCCCCCCCCCCEEE	49.95	27841257
350	Phosphorylation	SVIVEVRSDDDKDED EEEEEEECCCCCCCC	51.04	27841257
358	Phosphorylation	DDDKDEDSRSQKSAV CCCCCCCCHHHHHCC	31.61	25338131
363	Phosphorylation	EDSRSQKSAVTDESE CCCHHHHHCCCCHHH	21.97	28066266
366	Phosphorylation	RSQKSAVTDESEMYD HHHHHCCCCHHHHHH	33.49	28066266
376	Phosphorylation	SEMYDMMTRGNLGLL HHHHHHHHHCCHHHH	28.87	25338131
428	Phosphorylation	PLDVVRKSCYSKDPS CHHHHHHHHCCCCHH	14.02	-
431	Phosphorylation	VVRKSCYSKDPSRVE HHHHHHCCCCHHHCC	34.60	-
435	Phosphorylation	SCYSKDPSRVEKREI HHCCCCHHHCCCCEE	60.12	-
466	Phosphorylation	YPHHRSLSGCPHKDR CCCCCCCCCCCCCCC	39.33	27841257
470	Phosphorylation	RSLSGCPHKDRIPPE CCCCCCCCCCCCCHH	49.04	24719451
473	Phosphorylation	SGCPHKDRIPPEILA CCCCCCCCCCHHHHH	48.38	24719451
477	Phosphorylation	HKDRIPPEILAMHEN CCCCCCHHHHHCCCC	45.33	24719451
508	Phosphorylation	SNRNTHRSLSGCPIA CCCCCCCCCCCCHHH	21.20	28066266
510	Phosphorylation	RNTHRSLSGCPIAAA CCCCCCCCCCHHHHH	39.33	22817900
570	Phosphorylation	RPNVAPATPRANLAK CCCCCCCCCCCCHHH	16.55	28066266
572	Methylation	NVAPATPRANLAKEL CCCCCCCCCCHHHHH	31.58	54541165
572	Dimethylation	NVAPATPRANLAKEL CCCCCCCCCCHHHHH	31.58	-
611	Phosphorylation	PKIQTSETSPKAFQC CCCCCCCCCCCCHHH	50.53	28066266
612	Phosphorylation	KIQTSETSPKAFQCF CCCCCCCCCCCHHHC	21.98	28066266
651	Phosphorylation	EMPENLSTKPQDLPS HCCCCCCCCCCCCCC	50.32	28059163
652	Ubiquitination	MPENLSTKPQDLPSK CCCCCCCCCCCCCCC	36.99	-
690	Phosphorylation	NTFPSSSSCSSSPGV CCCCCCCCCCCCCCC	21.70	24759943
692	Phosphorylation	FPSSSSCSSSPGVKS CCCCCCCCCCCCCCC	35.48	24759943
693	Phosphorylation	PSSSSCSSSPGVKSP CCCCCCCCCCCCCCC	44.90	24759943
694	Phosphorylation	SSSSCSSSPGVKSPD CCCCCCCCCCCCCCC	14.91	24759943
718	Phosphorylation	APSSSMTSPQSSQAS CCCCCCCCCCCHHCC	16.58	23527152
759	Phosphorylation	PAAHSFASSEADDQE CCHHHHHCCCCCCHH	27.05	27841257
824	Phosphorylation	YASHRSLSGCPLADK CCCCCCCCCCCCCCH	39.33	19060867
874	Acetylation	LSGCPRAKKSGLKVA CCCCCCCHHCCCEEC	49.07	7613319
991	Phosphorylation	LSGDEILSPKFKTSD CCCCCCCCCCCCHHH	31.53	28066266
996	Phosphorylation	ILSPKFKTSDVLEND CCCCCCCHHHHHCCH	33.04	29899451
997	Phosphorylation	LSPKFKTSDVLENDE CCCCCCHHHHHCCHH	26.72	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYT1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYT1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIN3B_MOUSE	Sin3b	physical	15935060

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.