PHF12_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHF12_MOUSE
• UniProt AC: Q5SPL2
• Protein Name: PHD finger protein 12
• Gene Name: Phf12 {ECO:0000312|EMBL:CAI25224.1}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1003
• Subcellular Localization: Nucleus .
• Protein Description: Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA (By similarity)..
• Protein Sequence: MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPEKESRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCCNPPLSEEMLPPGEWMCHRCTVRRKKREQKKELGHVNGLVDKSSKRTTSPSSDTDLLDRPASKTELKAIAHARILERRASRPGTPTSNASTETPTSEHNDVDEDIVDVDEEPVAAEPDYVQPQLRRPFELLIAAAMERNPTQFQLPNELTCTTALPGSSKRRRKEETTGKNVKRTQHELDHNGLVPLPVKVCFTCNRSCRVAPLIQCDYCPLLFHMDCLEPPLTAMPLGRWMCPNHIEHVVLNQKNLTLSNRCQVFDRFQDTISQHVVKVDFLNRIHKKHPPNRRVLQSVKRRSLKVPDAIKSQYQFPPPLIAPAAIRDGELICSGVPEESQTHLLNSEHLATQAEQQEWLCSVVALQCSILKHLSAKQMPSPWDSEQTEKADIKPVIVTDSSITTSLQTADKAPLPSHYPLSCPSAVSTQNSLGCSPPHQPPTLEDISCSSCVEKSKKAPCGTANGPVNTEIKANGPHLYSSPTDSTDPRRLPGANTPLPGLTHRQGWPRPLTPPSAGGLQNHVGIIVKTENATGPSSCPQRSLVPVPSLPPSIPSSCASIENTSTLHRKTVQSQIGPSSTESRPLGSPPNATRVLTPPQAAGDSILATGANQRFCSPAPSSDGKVSPGTLSIGSALTVPSFPANSTAMVDLTNSLRAFMDVNGEIEINMLDEKLIKFLALQRVHQLFPSRVQASPGNVGTHPLASGGHHPEVQRKEVQARAVFCPLLGLGGAVNMCYRTLYIGTGADMDVCLTNYGHCNYVSGKHACIFYDENTKHYELLNYSEHGTTVDNVLYSCDFSEKTPPTPPSSIVAKVQSVIRRRRHQKQDEEPSEEAAMMSSQAQGPQRRPCNCKASSSSLIGGSGAGWEGTALLHHGSYIKLGCLQFVFSITEFATKQPKGDASLLQDGVLAEKLSLKPHQGPVLRSNSVP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	TDEAEKRSRKPEKES CCHHHHHCCCCCHHH	56.58	22802335
47	Phosphorylation	SRKPEKESRRSGRAT CCCCCHHHHHCCCCC	44.02	22802335
129	Phosphorylation	VDKSSKRTTSPSSDT CCCCCCCCCCCCCCC	35.05	25619855
130	Phosphorylation	DKSSKRTTSPSSDTD CCCCCCCCCCCCCCC	42.55	21082442
131	Phosphorylation	KSSKRTTSPSSDTDL CCCCCCCCCCCCCCC	23.36	26824392
133	Phosphorylation	SKRTTSPSSDTDLLD CCCCCCCCCCCCCCC	40.38	21082442
134	Phosphorylation	KRTTSPSSDTDLLDR CCCCCCCCCCCCCCC	48.16	27149854
136	Phosphorylation	TTSPSSDTDLLDRPA CCCCCCCCCCCCCCC	30.41	25168779
144	Phosphorylation	DLLDRPASKTELKAI CCCCCCCCHHHHHHH	42.67	25619855
162	Phosphorylation	RILERRASRPGTPTS HHHHHHHCCCCCCCC	36.88	29514104
166	Phosphorylation	RRASRPGTPTSNAST HHHCCCCCCCCCCCC	26.52	25338131
172	Phosphorylation	GTPTSNASTETPTSE CCCCCCCCCCCCCCC	30.90	25338131
501	Phosphorylation	LSCPSAVSTQNSLGC CCCCCCCCCCCCCCC	24.80	25293948
502	Phosphorylation	SCPSAVSTQNSLGCS CCCCCCCCCCCCCCC	25.77	25293948
505	Phosphorylation	SAVSTQNSLGCSPPH CCCCCCCCCCCCCCC	19.13	25293948
509	Phosphorylation	TQNSLGCSPPHQPPT CCCCCCCCCCCCCCC	39.40	25293948
516	Phosphorylation	SPPHQPPTLEDISCS CCCCCCCCHHHCCCH	49.84	25293948
521	Phosphorylation	PPTLEDISCSSCVEK CCCHHHCCCHHHCHH	21.92	25293948
523	Phosphorylation	TLEDISCSSCVEKSK CHHHCCCHHHCHHHC	21.71	25293948
524	Phosphorylation	LEDISCSSCVEKSKK HHHCCCHHHCHHHCC	26.89	25293948
555	Phosphorylation	NGPHLYSSPTDSTDP CCCCCCCCCCCCCCC	20.47	25338131
557	Phosphorylation	PHLYSSPTDSTDPRR CCCCCCCCCCCCCCC	44.52	-
570	Phosphorylation	RRLPGANTPLPGLTH CCCCCCCCCCCCCCC	26.18	27600695
586	Phosphorylation	QGWPRPLTPPSAGGL CCCCCCCCCCCCCCC	35.52	25266776
644	Phosphorylation	TSTLHRKTVQSQIGP CCCCCHHHHHHHCCC	24.59	25777480
647	Phosphorylation	LHRKTVQSQIGPSST CCHHHHHHHCCCCCC	21.30	25777480
652	Phosphorylation	VQSQIGPSSTESRPL HHHHCCCCCCCCCCC	44.68	26239621
653	Phosphorylation	QSQIGPSSTESRPLG HHHCCCCCCCCCCCC	39.05	26745281
654	Phosphorylation	SQIGPSSTESRPLGS HHCCCCCCCCCCCCC	42.17	26745281
656	Phosphorylation	IGPSSTESRPLGSPP CCCCCCCCCCCCCCC	39.01	26745281
661	Phosphorylation	TESRPLGSPPNATRV CCCCCCCCCCCCCEE	44.88	21082442
666	Phosphorylation	LGSPPNATRVLTPPQ CCCCCCCCEECCCCH	28.13	25619855
670	Phosphorylation	PNATRVLTPPQAAGD CCCCEECCCCHHCCC	30.02	23527152
678	Phosphorylation	PPQAAGDSILATGAN CCHHCCCCEECCCCC	20.70	28833060
682	Phosphorylation	AGDSILATGANQRFC CCCCEECCCCCCCCC	33.12	28833060
690	Phosphorylation	GANQRFCSPAPSSDG CCCCCCCCCCCCCCC	22.76	26643407
694	Phosphorylation	RFCSPAPSSDGKVSP CCCCCCCCCCCCCCC	43.07	26643407
695	Phosphorylation	FCSPAPSSDGKVSPG CCCCCCCCCCCCCCC	49.69	26643407
700	Phosphorylation	PSSDGKVSPGTLSIG CCCCCCCCCCEEEEC	22.54	26643407
703	Phosphorylation	DGKVSPGTLSIGSAL CCCCCCCEEEECCCE	22.25	26643407
705	Phosphorylation	KVSPGTLSIGSALTV CCCCCEEEECCCEEC	25.41	26643407
708	Phosphorylation	PGTLSIGSALTVPSF CCEEEECCCEECCCC	20.59	26643407
711	Phosphorylation	LSIGSALTVPSFPAN EEECCCEECCCCCCC	30.04	26643407
714	Phosphorylation	GSALTVPSFPANSTA CCCEECCCCCCCCCE	39.25	26643407
719	Phosphorylation	VPSFPANSTAMVDLT CCCCCCCCCEEEECC	21.46	26643407
720	Phosphorylation	PSFPANSTAMVDLTN CCCCCCCCEEEECCH	20.69	26643407
768	Phosphorylation	FPSRVQASPGNVGTH CCCCCCCCCCCCCCC	19.09	28507225
774	Phosphorylation	ASPGNVGTHPLASGG CCCCCCCCCCCCCCC	18.94	26643407
779	Phosphorylation	VGTHPLASGGHHPEV CCCCCCCCCCCCHHH	53.65	26643407
876	Phosphorylation	SCDFSEKTPPTPPSS CCCCCCCCCCCCCHH	30.37	28833060
879	Phosphorylation	FSEKTPPTPPSSIVA CCCCCCCCCCHHHHH	49.38	26824392
882	Phosphorylation	KTPPTPPSSIVAKVQ CCCCCCCHHHHHHHH	33.62	28066266
883	Phosphorylation	TPPTPPSSIVAKVQS CCCCCCHHHHHHHHH	27.19	28066266
912	Phosphorylation	SEEAAMMSSQAQGPQ HHHHHHHHHHCCCCC	13.25	22802335

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHF12_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHF12_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHF12_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIN3B_MOUSE	Sin3b	physical	21041482
MO4L1_MOUSE	Morf4l1	physical	21041482
HDAC1_MOUSE	Hdac1	physical	21041482

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.