ARI4B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARI4B_MOUSE
• UniProt AC: A2CG63
• Protein Name: AT-rich interactive domain-containing protein 4B
• Gene Name: Arid4b
• Organism: Mus musculus (Mouse).
• Sequence Length: 1314
• Subcellular Localization: Nucleus .
• Protein Description: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity)..
• Protein Sequence: MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEEERKQTDELLGKVVCVDYVSLEKKKAMWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQALEFHKSRAIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKEETPAEDESERKENIKPSLGSKKSLLECIPAQSDEEKEAHITKLEENENLEDKDGGRARTEEAFSTEVDGEEEQARSGDETNKEEDEDDEEIEEEEEEDEEEDEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEALYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDRDEKYSPKNCKLRRLSKSPFQSNPSPEMVSKLDLADAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERCTQDVDNIGKDESKVEHSTHSRNELISKEEQSSPSLLEENKVHTDLVIAKTVSKSPERLRKDMEAISEDTDFEEEDEITKKRKDVKKDTTDKALKPQTKRGKRRYCSADECLQTGSPGKKEDRTKSKEPLCTENSSNSSSDEDEEEKSKAKMTPTKKYNGLEEKRKSLRTTSFYSGFSEVAEKRIKLLNNSDERLQNNRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPDEGAVEESLQTVAEEESCSPIMELEKPLPASVDNKPIEEKPLEVSDRKTEFPSSGSNSVLNTPPTTPESPSSVTITEASQQQSSVTVSVPLPPNQEEVRSIKSETDSTIEVDSVVGELQDLQSEGNSSPAGFDASVSSSSSNQPEPDNPEKACTGQKRVKDTQGVGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESVTKTQTIKSVPTGMKTHNSKSPARVQSPGKGGRNGDKDPDLKEPSNRLPKVYKWSFQTSDLENMTSAERISILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Phosphorylation	VTFRHDSSTVEVQDD EEEECCCCCEEEECC	42.39	23684622
48	Phosphorylation	TFRHDSSTVEVQDDH EEECCCCCEEEECCC	25.33	23684622
105	Phosphorylation	EKTLRRSSLCLKGER CEEEEHHEEHHCCCC	22.69	25338131
133	Phosphorylation	TNPEHFGTPVIGKKT CCHHHCCCCCCCCCC	17.28	26643407
181	Phosphorylation	GKVVCVDYVSLEKKK HHEEEEEEECCCCCH	3.29	28059163
183	Phosphorylation	VVCVDYVSLEKKKAM EEEEEEECCCCCHHC	25.28	28059163
267	Phosphorylation	AIPANWKTELKEDSS CCCCCCCHHCCCCCC	37.86	19854140
273	Phosphorylation	KTELKEDSSSSEAEE CHHCCCCCCCCHHHH	32.96	28285833
274	Phosphorylation	TELKEDSSSSEAEEE HHCCCCCCCCHHHHH	50.64	23375375
275	Phosphorylation	ELKEDSSSSEAEEEE HCCCCCCCCHHHHHH	35.83	23375375
276	Phosphorylation	LKEDSSSSEAEEEEE CCCCCCCCHHHHHHH	42.65	22817900
295	Phosphorylation	EKEKEDNSSEEEEEI HHHHCCCCCHHHHHH	51.99	25521595
296	Phosphorylation	KEKEDNSSEEEEEIE HHHCCCCCHHHHHHC	56.11	25521595
431	Phosphorylation	EVKVKEESETEIKEV CCEECCCCCCCEEEE	51.41	25266776
433	Phosphorylation	KVKEESETEIKEVNV EECCCCCCCEEEECH	52.90	29550500
473	Phosphorylation	PSLGSKKSLLECIPA CCCCCCHHHHHHCCC	41.76	25619855
482	Phosphorylation	LECIPAQSDEEKEAH HHHCCCCCHHHHHHH	49.44	25521595
491	Phosphorylation	EEKEAHITKLEENEN HHHHHHEEHHHHCCC	21.51	21743459
526	Phosphorylation	GEEEQARSGDETNKE CCHHHHHCCCCCCCC	54.32	25195567
656	Phosphorylation	KDRDEKYSPKNCKLR CCCCCCCCCCCCCCC	40.23	25266776
666	Phosphorylation	NCKLRRLSKSPFQSN CCCCCCCCCCCCCCC	29.31	19060867
668	Phosphorylation	KLRRLSKSPFQSNPS CCCCCCCCCCCCCCC	27.80	23375375
672	Phosphorylation	LSKSPFQSNPSPEMV CCCCCCCCCCCHHHH	51.60	25619855
675	Phosphorylation	SPFQSNPSPEMVSKL CCCCCCCCHHHHHHC	37.43	25521595
680	Phosphorylation	NPSPEMVSKLDLADA CCCHHHHHHCCHHHH	26.62	25619855
717	Phosphorylation	SESSAEDSEQEDERC CCCCCCCCHHHHHHH	32.46	25293948
750	Phosphorylation	HSRNELISKEEQSSP CCHHHHCCHHHHCCC	46.79	29514104
755	Phosphorylation	LISKEEQSSPSLLEE HCCHHHHCCCCHHHC	47.71	30352176
756	Phosphorylation	ISKEEQSSPSLLEEN CCHHHHCCCCHHHCC	20.43	26824392
758	Phosphorylation	KEEQSSPSLLEENKV HHHHCCCCHHHCCCC	47.75	26643407
774	Phosphorylation	TDLVIAKTVSKSPER CCCEEEEECCCCHHH	22.46	22817900
776	Phosphorylation	LVIAKTVSKSPERLR CEEEEECCCCHHHHH	32.42	25266776
778	Phosphorylation	IAKTVSKSPERLRKD EEEECCCCHHHHHHH	25.20	26824392
790	Phosphorylation	RKDMEAISEDTDFEE HHHHHHHHCCCCCHH	36.15	27087446
793	Phosphorylation	MEAISEDTDFEEEDE HHHHHCCCCCHHHHH	38.24	27087446
802	Phosphorylation	FEEEDEITKKRKDVK CHHHHHHHHHHHHHC	28.59	28833060
803	Acetylation	EEEDEITKKRKDVKK HHHHHHHHHHHHHCC	57.13	30985461
813	Phosphorylation	KDVKKDTTDKALKPQ HHHCCCCCCCCCCCC	45.71	-
828	Phosphorylation	TKRGKRRYCSADECL CCCCCCCEECHHHHH	8.52	28833060
830	Phosphorylation	RGKRRYCSADECLQT CCCCCEECHHHHHHC	29.80	25619855
837	Phosphorylation	SADECLQTGSPGKKE CHHHHHHCCCCCCCC	27.03	25619855
839	Phosphorylation	DECLQTGSPGKKEDR HHHHHCCCCCCCCCC	33.59	27087446
876	Phosphorylation	EKSKAKMTPTKKYNG HHHHHCCCCCHHCCC	27.40	-
895	Phosphorylation	RKSLRTTSFYSGFSE HHHHHHCHHCCCCHH	22.90	27600695
898	Phosphorylation	LRTTSFYSGFSEVAE HHHCHHCCCCHHHHH	31.20	27600695
906	Acetylation	GFSEVAEKRIKLLNN CCHHHHHHHHHHHCC	50.08	23806337
914	Phosphorylation	RIKLLNNSDERLQNN HHHHHCCCHHHHHHC	39.51	25266776
993	Phosphorylation	LEKPLPASVDNKPIE CCCCCCCCCCCCCCC	28.23	27841257
1016	Phosphorylation	RKTEFPSSGSNSVLN CCCCCCCCCCCCCCC	46.62	-
1028	Phosphorylation	VLNTPPTTPESPSSV CCCCCCCCCCCCCCE	30.72	-
1031	Phosphorylation	TPPTTPESPSSVTIT CCCCCCCCCCCEEEE	31.14	-
1152	Phosphorylation	NKKKGKGTNSSDSEE CCCCCCCCCCCCHHC	35.10	25619855
1154	Phosphorylation	KKGKGTNSSDSEELS CCCCCCCCCCHHCCC	35.05	25619855
1155	Phosphorylation	KGKGTNSSDSEELSA CCCCCCCCCHHCCCC	47.42	26824392
1157	Phosphorylation	KGTNSSDSEELSAGE CCCCCCCHHCCCCCC	34.61	25619855
1161	Phosphorylation	SSDSEELSAGESVTK CCCHHCCCCCCCCCC	37.19	25619855
1165	Phosphorylation	EELSAGESVTKTQTI HCCCCCCCCCCCCEE	33.88	30635358
1186	Phosphorylation	MKTHNSKSPARVQSP CCCCCCCCCCCCCCC	24.50	23375375
1192	Phosphorylation	KSPARVQSPGKGGRN CCCCCCCCCCCCCCC	32.53	22324799
1251	Phosphorylation	EIRKHYLSLKSEVAS HHHHHHHHHHHHHHH	26.95	25266776
1254	Phosphorylation	KHYLSLKSEVASIDR HHHHHHHHHHHHHHH	42.47	25266776
1285	Phosphorylation	SSSSSPSSSSITAAV CCCCCCCHHHHHHHH	31.33	-
1289	Phosphorylation	SPSSSSITAAVMLTL CCCHHHHHHHHHHHH	15.54	-
1295	Phosphorylation	ITAAVMLTLAEPSMS HHHHHHHHHCCCCCC	13.06	21183079
1300	Phosphorylation	MLTLAEPSMSSASQN HHHHCCCCCCCHHHC	23.85	21183079
1302	Phosphorylation	TLAEPSMSSASQNGM HHCCCCCCCHHHCCC	27.39	-
1303	Phosphorylation	LAEPSMSSASQNGMS HCCCCCCCHHHCCCC	24.25	-
1310	Phosphorylation	SASQNGMSVECR--- CHHHCCCCCCCC---	19.03	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARI4B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARI4B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARI4B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ARI4B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.