SPI2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPI2_HUMAN
• UniProt AC: O75830
• Protein Name: Serpin I2
• Gene Name: SERPINI2
• Organism: Homo sapiens (Human).
• Sequence Length: 405
• Subcellular Localization: Secreted .
• Protein Sequence: MDTIFLWSLLLLFFGSQASRCSAQKNTEFAVDLYQEVSLSHKDNIIFSPLGITLVLEMVQLGAKGKAQQQIRQTLKQQETSAGEEFFVLKSFFSAISEKKQEFTFNLANALYLQEGFTVKEQYLHGNKEFFQSAIKLVDFQDAKACAEMISTWVERKTDGKIKDMFSGEEFGPLTRLVLVNAIYFKGDWKQKFRKEDTQLINFTKKNGSTVKIPMMKALLRTKYGYFSESSLNYQVLELSYKGDEFSLIIILPAEGMDIEEVEKLITAQQILKWLSEMQEEEVEISLPRFKVEQKVDFKDVLYSLNITEIFSGGCDLSGITDSSEVYVSQVTQKVFFEINEDGSEAATSTGIHIPVIMSLAQSQFIANHPFLFIMKHNPTESILFMGRVTNPDTQEIKGRDLDSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MDTIFLWSLLLLFFG CCHHHHHHHHHHHHH	15.99	24043423
16	Phosphorylation	LLLLFFGSQASRCSA HHHHHHHHCHHHCCC	19.88	24043423
19	Phosphorylation	LFFGSQASRCSAQKN HHHHHCHHHCCCCCC	26.61	24043423
48	Phosphorylation	HKDNIIFSPLGITLV CCCCEEECCCCHHHH	14.60	25332170
76	Acetylation	QQIRQTLKQQETSAG HHHHHHHHHHCCCCC	54.01	7683043
184	Phosphorylation	LVLVNAIYFKGDWKQ EEEEEEEEECCCHHH	9.23	27259358
202	N-linked_Glycosylation	KEDTQLINFTKKNGS HHHCEEEEEECCCCC	47.31	UniProtKB CARBOHYD
204	Phosphorylation	DTQLINFTKKNGSTV HCEEEEEECCCCCCC	36.30	29457462
207	N-linked_Glycosylation	LINFTKKNGSTVKIP EEEEECCCCCCCCHH	51.72	UniProtKB CARBOHYD
224	Phosphorylation	KALLRTKYGYFSESS HHHHHHCCCCCCCHH	19.22	-
247	Phosphorylation	SYKGDEFSLIIILPA EECCCEEEEEEEEEC	19.33	25332170
286	Phosphorylation	QEEEVEISLPRFKVE HHHHEEEECCCCEEE	20.86	24719451
306	N-linked_Glycosylation	KDVLYSLNITEIFSG HHHHHHCCCCEEECC	32.94	UniProtKB CARBOHYD
394	Phosphorylation	GRVTNPDTQEIKGRD EECCCCCCCCCCCCC	29.38	22985185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPI2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPI2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPI2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBQL1_HUMAN	UBQLN1	physical	16189514
UBQL1_HUMAN	UBQLN1	physical	25416956
SGTB_HUMAN	SGTB	physical	21516116
BAG6_HUMAN	BAG6	physical	21516116

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.